4,6,10-Trioxa-5-phosphaoctacos-19-enoicacid,2-amino-5-hydroxy-11-oxo-8-[[(9Z)-1-oxo-9-octadecenyl]oxy]-,5-oxide,sodiumsalt,(2S,8R,19Z)-

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 4,6,10-Trioxa-5-phosphaoctacos-19-enoicacid,2-amino-5-hydroxy-11-oxo-8-[[(9Z)-1-oxo-9-octadecenyl]oxy]-,5-oxide,sodiumsalt,(2S,8R,19Z)-
• 英文别名: disodium;(2S)-2-amino-3-[[(2R)-2,3-bis[[(Z)-octadec-9-enoyl]oxy]propoxy]-oxidophosphoryl]oxypropanoate
• 化学式: C42H76NNa2O10P
• 分子量: 832.0
• InChiKey: VDNMBCVCXGBYSY-FVRRZPIUSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  56
• 可旋转键数：
  41
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  177
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• Functional associative coatings for nanoparticles
  申请人：Hainfeld James F.

  公开号：US20080089836A1

  公开（公告）日：2008-04-17

  Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

  本文描述了一种纳米颗粒，其表面涂覆有由表面结合分子和两亲分子形成的双层分子层。该双层涂层可以自组装在纳米颗粒上，使用易得的材料/分子。双层涂层纳米颗粒的模块化设计提供了一种方便和高效地优化其性质的方法。此外，本文还描述了这种纳米颗粒在医学、实验室技术、工业和商业应用中的用途。
• Screening method
  申请人：Mori Masaaki

  公开号：US20050154190A1

  公开（公告）日：2005-07-14

  The present invention relates to a screening method/screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 19, its partial peptides, or salts thereof, and (b) a ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; pharmaceuticals comprising the compounds or salts thereof; a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 19; etc. The compounds obtained by the screening of the present invention are useful as agents for the prevention/treatment of, for example, neurodegenerative diseases, immunological diseases, edema, acid indigestion, etc.

  本发明涉及一种筛选方法/筛选试剂盒，用于筛选改变(a)与SEQ ID NO:1或SEQ ID NO:19所代表的氨基酸序列相同或基本相同的蛋白质、其部分肽段或其盐的结合性质，以及(b)能够特异性结合于蛋白质的配体的化合物或其盐。本发明筛选得到的化合物或其盐；包含该化合物或其盐的药物；与SEQ ID NO:19所代表的氨基酸序列相同或基本相同的蛋白质等均属于本发明的范畴。本发明所筛选得到的化合物可用作预防/治疗神经退行性疾病、免疫性疾病、水肿、酸性消化不良等的药剂。
• ARCHAEAL POLAR LIPID AGGREGATES FOR ADMINISTRATION TO ANIMALS
  申请人：PATEL GIRISHCHANDRA B.

  公开号：US20080220028A1

  公开（公告）日：2008-09-11

  The invention provides non-replicating compositions, and methods for the delivery of these compositions containing pharmaceuticals, biologically relevant molecules, and/or antigens to the host, by administration via a mucosal route such as the intranasal. This invention provides non-replicating vaccine compositions and methods for the delivery of antigens in these vaccine compositions comprising an antigen and a self-adjuvanting carrier, useful for inducing antigen-specific mucosal and systemic immune responses in the host upon immunization via a mucosal route such as intranasal. The vaccine compositions comprise multivalent cations in association with a plurality of spherical archaeal polar lipid aggregates containing aqueous compartments, the AMVAD structure, formed by the interaction of archaeosomes and antigen(s) with multivalent cations such as Ca 2+ , wherein the AMVAD structure acts as a self-adjuvanting carrier for the antigen(s) in the vaccine composition. Certain advantageous immune responses can also be elicited with the subject compositions.

  本发明提供非复制组合物和传递这些组合物的方法，包含药物、生物相关分子和/或抗原，通过粘膜途径如鼻内给药途径传递给宿主。本发明提供非复制疫苗组合物和传递这些疫苗组合物的方法，包含抗原和自我免疫佐剂载体，用于通过粘膜途径如鼻内接种诱导宿主的特异性粘膜和全身免疫反应。疫苗组合物包含多价阳离子与多个球形古菌极性脂质聚集体相结合，该聚集体包含水相区域，即AMVAD结构，通过古菌体和抗原与多价阳离子（如Ca2+）的相互作用形成，其中AMVAD结构作为疫苗组合物中抗原的自我免疫佐剂载体。本发明的组合物还能引起某些有利的免疫反应。
• IL-13 Production Inhibitor
  申请人：Ogi Kazuhiro

  公开号：US20090170116A1

  公开（公告）日：2009-07-02

  The present invention provides a screening method/screening kit for an IL-13 production inhibitor, which comprises using (a) a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or its partial peptide, or a salt thereof; and (b) a ligand capable of specifically binding to the protein; an IL-13 production inhibitor which is obtainable by said screening, and the like. The IL-13 production inhibitor which can be obtained by the screening of the present invention is useful as a prophylactic/therapeutic agent for, e.g., respiratory disease, etc.

  本发明提供了一种筛选IL-13产生抑制剂的筛选方法/筛选试剂盒，其包括使用(a)一种蛋白质，该蛋白质包括与由SEQ ID NO:1所代表的氨基酸序列相同或基本相同的氨基酸序列，或其部分肽段或其盐；和(b)能够特异性结合于该蛋白质的配体。通过该筛选获得的IL-13产生抑制剂等。本发明筛选所获得的IL-13产生抑制剂可用作呼吸系统疾病等的预防/治疗剂。
• SCREENING METHOD
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1455186A1

  公开（公告）日：2004-09-08

  The present invention relates to a screening method/ screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:. 1 or SEQ ID NO: 19, its: partial peptides, or salts thereof, and (b) a ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; pharmaceuticals comprising the compounds or salts thereof; a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 19; etc. The compounds obtained by the screening of the present invention are useful as agents for the prevention/treatment of, for example, neurodegenerative diseases, immunological diseases, edema, acid indigestion, etc.

  本发明涉及一种筛选方法/筛选试剂盒，用于筛选能改变(a)含有与SEQ ID NO：1或SEQ ID NO：19所代表的氨基酸序列相同或基本相同的氨基酸序列的蛋白质、其部分肽或其盐的结合特性的化合物或其盐；(b)能与该蛋白质特异性结合的配体；通过筛选获得的化合物或其盐；(c)能与该蛋白质特异性结合的配体。1 或 SEQ ID NO: 19 所代表的氨基酸序列相同或基本相同的蛋白质、其部分肽或其盐，以及(b) 能与该蛋白质特异性结合的配体；通过筛选获得的化合物或其盐；包含该化合物或其盐的药物；含有与 SEQ ID NO: 19 所代表的氨基酸序列相同或基本相同的氨基酸序列的蛋白质；等等。通过本发明筛选获得的化合物可用作预防/治疗神经退行性疾病、免疫疾病、水肿、胃酸消化不良等疾病的药物。