3,4-dihydro-13-(4-isopropylphenyl)-3,3-dimethyl-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione | 1245471-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3,4-dihydro-13-(4-isopropylphenyl)-3,3-dimethyl-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione
• 英文别名: 3,4-dihydro-3,3-dimethyl-13-(4-isopropylphenyl)-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione；3,3-dimethyl-13-(4-isopropylphenyl)-3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H, 13H)-trione；3,4-dihydro-13-(4-isopropylphenyl)-3,3-dimethyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione；13-(4-isopropylphenyl)-3,3-dimethyl-2,3,4,13-tetrahydro-1H-indazolo[1,2-b]phthalazine-1,6,11-trione；13-(4-isopropylphenyl)-3,3-dimethyl-3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H,13H)-trione；2,3,4,13-tetrahydro-13-(4-isopropylphenyl)-3,3-dimethyl-1H-indazolo[1,2-b]phthalazine-1,6,11-trione；2,3,4,13-tetrahydro-3,3-dimethyl-13-(4-isopropylphenyl)-indazolo[2,1-b]phtha-lazine-1,6,11-trione；2,3,4,13-Tetrahydro-3,3-dimethyl-13-(4-isopropylphenyl)-indazolo[2,1-b]phthalazine-1,6,11-trione；3,3-dimethyl-13-(4-propan-2-ylphenyl)-4,13-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11-trione
• CAS: 1245471-24-2
• 化学式: C₂₆H₂₆N₂O₃
• 分子量: 414.504
• InChiKey: IESWTPKLODHNHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯酐 在 一水合肼 作用下， 以 neat (no solvent) 为溶剂， 反应 1.33h， 生成 3,4-dihydro-13-(4-isopropylphenyl)-3,3-dimethyl-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione
  参考文献：
  名称：

  Sb(iii)/Gum Arabic composite as a new natural-based environmentally green catalyst for the one-pot pseudo-four-component synthesis of 2H-indazolo[2,1-b] phthalazinetriones

  摘要：

  合成了一种独特的天然无毒催化剂--Sb(iii)-阿拉伯胶复合材料，并通过 FT-IR、XRD、TGA、ICP、BET、EDX 和绘图对其进行了表征。

  DOI：

  10.1039/d3ra02556j

文献信息

• An efficient and green one-pot synthesis of indazolo[1,2-b]-phthalazinetriones via three-component reaction of aldehydes, dimedone, and phthalhydrazide using Fe3O4@SiO2 core–shell nanoparticles
  作者：Boshra Mirhosseini-Eshkevari、Mohammad Ali Ghasemzadeh、Javad Safaei-Ghomi

  DOI：10.1007/s11164-014-1854-8

  日期：2015.10

  An efficient and eco-friendly procedure for the one-pot synthesis of biologically active heterocyclic compounds including indazolo[1,2- b ]-phthalazinetriones has been developed in the presence of Fe3O4@SiO2 nanoparticles. The multicomponent reactions of aldehydes, dimedone, and phthalhydrazide were carried out under solvent-free conditions to obtain some indazolo[1,2- b ]-phthalazinetrione derivatives

  在Fe 3 O 4 @SiO 2纳米粒子的存在下，已经开发出了一种有效且环保的方法，用于一锅合成生物活性杂环化合物，包括吲哚并[1,2- b ]-酞嗪三酮。在无溶剂条件下进行醛，二甲酮和邻苯二甲酰肼的多组分反应，得到一些吲唑并[1,2- b ]-酞嗪三酮衍生物。本方法提供了许多优点，例如优异的收率，简单的后处理，低的反应时间，容易的催化剂分离和很少的催化剂负载。
• Solvent-free, sonochemical, one-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones and 1H-pyrazolo[1,2-b]phthalazine-diones catalyzed by Fe3O4@SiO2-imid-PMAn magnetic nanoparticles
  作者：Mohsen Esmaeilpour、Jaber Javidi、Fatemeh Nowroozi Dodeji、Saeed Zahmatkesh

  DOI：10.1007/s11164-016-2462-6

  日期：2021.6

  A practical and green method for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones and 1H-pyrazolo[1,2-b]phthalazine-diones using Fe3O4@SiO2-imid-PMAn nanoparticles as an eco-friendly magnetic catalyst from the four-component condensation, solvent-free reaction of phthalic anhydride, hydrazinium hydroxide, 1,3-diketones, and aldehydes under thermal or ultrasound irradiation at room temperature

  一种使用 Fe 3 O 4 @SiO 2 -imid-PMA合成 2 H -吲唑并[2,1- b ]酞嗪三酮和 1 H -吡唑并[1,2- b ]酞嗪二酮的实用绿色方法n描述了纳米粒子作为一种环保磁性催化剂，来自邻苯二甲酸酐、氢氧化肼、1,3-二酮和醛的四组分缩合、无溶剂反应，在室温下进行热或超声辐照。这种新方法具有显着的优点，例如操作简单、产率高、反应时间短以及没有任何繁琐的后处理或纯化。此外，催化剂的热稳定性、易于制备和分离使其成为一种良好的多相体系，是其他多相催化剂的有用替代品。此外，催化剂可以很容易地通过磁场回收并重复使用八个连续的反应循环而不会显着损失活性。
• A new natural based ionic liquid 3-sulfonic acid 1-imidazolopyridinium hydrogen sulfate as an efficient catalyst for the preparation of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones
  作者：Reza Tayebee、Malihe Jomei、Behrooz Maleki、Maryam Kargar Razi、Hojat Veisi、Mohammad Bakherad

  DOI：10.1016/j.molliq.2015.02.021

  日期：2015.6

  A novel Brønsted acidic ionic liquid 3-sulfonic acid 1-imidazolopyridinium hydrogen sulfate [Simp]HSO4 was synthesized via the reaction of caffeine with chlorosulfonic acid and was characterized by studying FT-IR, 1H NMR, 13C NMR, UV–Vis, and fluorescence spectra. Then, the prepared ionic liquid was utilized as an efficient catalyst for the preparation of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione

  通过咖啡因与氯磺酸的反应合成了一种新型的布朗斯台德酸性离子液体3-磺酸1-咪唑并吡啶鎓硫酸氢盐[Simp] HSO 4，并通过FT-IR，1 H NMR，13 C NMR，UV-Vis进行了表征和荧光光谱。然后，将制备的离子液体用作通过一锅多醛缩合制备2H-吲唑并[2,1-b]酞嗪-1,6,11（13H）-三酮衍生物的有效催化剂。 ，邻苯二甲酰肼和二甲酮在无溶剂的条件下使用。该催化剂的高布朗斯台德酸性功能主要源自SO 3 H基团的双重氢键结合能力。
• Phosphomolybdic Acid (PMA)-SiO2 as a Heterogeneous Solid Acid Catalyst for the One-Pot Synthesis of 2H-Indazolo[1,2-b]phthalazine-triones
  作者：Gowravaram Sabitha、Chitti Srinivas、Avula Raghavendar、Jhillu Singh Yadav

  DOI：10.1002/hlca.200900378

  日期：——

  Phosphomolybdic acid (PMA)–SiO2 was found to be an efficient catalyst for the three‐component condensation reaction of phthalhydrazide, 1,3‐diketone, and aldehydes to produce 2H‐indazolo[1,2‐b]phthalazine‐triones in excellent yields. The catalyst can be recovered and reused without significant loss of activity.

  磷钼酸（PMA）-SiO 2被发现是邻苯二甲酰肼，1,3-二酮和醛的三组分缩合反应产生2 H-吲唑并[1,2 - b ]邻苯二甲腈-三酮的有效催化剂。优异的产量。催化剂可被回收和再利用而没有明显的活性损失。
• Silica-supported tungstic acid (STA): A recyclable catalyst for the synthesis of <i>1H</i>-indazolo [1,2-<i>b</i>]phthalazine-trione and spiro-triazolo[1,2-<i>a</i>]indazole-tetraone derivatives under solvent-free condition
  作者：Amol Maruti Jadhav、Sandip Gangadhar Balwe、Yeon Tae Jeong

  DOI：10.1080/10426507.2019.1661414

  日期：2020.3.3

  Abstract An efficient one-pot synthesis of 1 H-indazolo[1,2-b]phthalazine-trione and spiro-triazolo[1,2-a]indazole-tetraone derivatives via three-component condensation reaction of phthalhydrazide or 4-phenylurazole, aldehydes or isatins and dimedone in the presence of a catalytic amount of silica-supported tungstic acid (STA), as a heterogeneous solid acid catalyst under solvent-free conditions is

  摘要 通过邻苯二甲酰肼或4-苯脲三组分缩合反应，高效一锅法合成1 H-吲唑并[1,2-b]酞嗪-三酮和螺-三唑并[1,2-a]吲唑-四酮衍生物，醛或靛红和二甲酮在催化量的二氧化硅负载钨酸 (STA) 存在下，作为无溶剂条件下的多相固体酸催化剂。这种生态友好的协议提供了几个优点，例如具有高产率、反应时间短、处理简单、回收和可重复使用的催化剂具有广泛的可用底物范围的具有成本效益的程序。这使得该协议具有可持续性和经济性。图形概要