1-vinyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline | 608522-84-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1-vinyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
• 英文别名: 1-vinylsalsolinol；1-Vinyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline；1-ethenyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol
• CAS: 608522-84-5
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: IFATZNWBHVCBTD-UHFFFAOYSA-N

物化性质

• 沸点：
  370.4±42.0 °C(Predicted)
• 密度：
  1.274±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  多巴胺 、 丙烯醛 以 水 为溶剂， 反应 72.0h， 生成 1-vinyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
  参考文献：
  名称：

  摘要：

  The synthesis of starburst polymer-protein conjugates on the basis of bovine serum albumin and horseradish peroxidase was performed with the aim to study the possibilities of regulation of the immune response against the components of the conjugates. These polymers had one-point binding between the protein and the modifying carbon-chain polymer that contained 1-vinyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (a salsolinol analogue) or bradykinin (peptide hormone) residues in its carbon chain. Changes in the chemical nature of the carbon-chain part of the polymer-protein conjugate were shown to increase or decrease the level of antibody production both against the low-molecular compounds attached to the polymeric fragments and against the protein carrier.

  DOI：

  10.1023/a:1022226418497

文献信息

• ——
  作者：G. P. Vlasov、G. A. Pankova、I. N. Nikonova、N. G. Antonov

  DOI：10.1023/a:1022226418497

  日期：——

  The synthesis of starburst polymer-protein conjugates on the basis of bovine serum albumin and horseradish peroxidase was performed with the aim to study the possibilities of regulation of the immune response against the components of the conjugates. These polymers had one-point binding between the protein and the modifying carbon-chain polymer that contained 1-vinyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (a salsolinol analogue) or bradykinin (peptide hormone) residues in its carbon chain. Changes in the chemical nature of the carbon-chain part of the polymer-protein conjugate were shown to increase or decrease the level of antibody production both against the low-molecular compounds attached to the polymeric fragments and against the protein carrier.