(10-bromodecyl)trimethylammonium Bromide | 36707-88-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (10-bromodecyl)trimethylammonium Bromide
• 英文别名: (10-bromo-decyl)-trimethyl-ammonium; bromide；(10-Brom-decyl)-trimethyl-ammonium; Bromid；10-bromodecyltrimethylammonium bromide；10-bromodecyl(trimethyl)azanium;bromide
• CAS: 36707-88-7
• 化学式: Br*C₁₃H₂₉BrN
• 分子量: 359.188
• InChiKey: VEAFAIWDEKMSMR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.21
• 重原子数：
  16
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (10-bromodecyl)trimethylammonium Bromide 、 甲烷 以 丙酮 、 乙腈 为溶剂， 生成 1,1-dibromodecane
  参考文献：
  名称：

  Chemical agents

  摘要：

  新的化学化合物，双季铵氨基甲酸酯，通式为：##STR1## 其中X为单价和多价阴离子中的一个当量，n为5-16，R，R.sub.1，R.sub.2为从甲基，乙基，丙基，异丙基和丁基等基团中选择的脂肪基，具有作为毒性剂的用途。

  公开号：

  US04241209A1
• 作为产物：
  描述：

  1,10-二溴癸烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 苯 作用下， 生成 (10-bromodecyl)trimethylammonium Bromide
  参考文献：
  名称：

  The Preparation of Some ι-Bromoalkyl Quaternary Ammonium Salts

  摘要：

  DOI：

  10.1021/ja01618a069

文献信息

• Orientational isomers of α-cyclodextrin [2]semi-rotaxanes with asymmetric dicationic threads
  作者：Andrew J. Baer、Donal H. Macartney

  DOI：10.1039/b418055k

  日期：——

  Two series of novel dicationic threading molecules [Quin(CH2)10R]2+ and [3,5-Lut(CH2)10R]2+, where Quin+ = quinuclidinium, 3,5-Lut+ = 3,5-lutidinium, and R+ = N(CH3)3+ and N(CH3)2CH2CH3+, form [2]semi-rotaxanes with α-cyclodextrin (α-CD) in aqueous solution. The quinuclidinium and 3,5-lutidinium are sufficiently bulky to prevent threading while the R+ groups allow for slow threading by α-CD at 25 °C. The resulting [2]semi-rotaxanes exist in two orientational isomers owing to the asymmetry of both the α-CD cavity and the threading molecules. Two-dimensional 1H NMR spectroscopy and kinetics experiments reveal that the isomer in which the narrower rim (primary OHs) is positioned near the R+ group is the kinetically preferred isomer, while the other isomer is the thermodynamically preferred product. The kinetics and mechanism of the formation, dissociation, and interconversion of the two isomers have been determined at 25 °C.

  两个系列的新型二阳离子穿线分子[Quin(CH2)10R]2+和[3,5-Lut(CH2)10R]2+（其中Quin+ = 喹啉鎓，3,5-Lut+ = 3,5-镏金鎓，R+ = N(CH3)3+和N(CH3)2CH2CH3+）在水溶液中与δ-环糊精（δ-CD）形成[2]半十字烷。其中的quinuclidinium和3,5-lutidinium具有足够大的体积，可以防止穿线，而R+基团则可以让δ-CD在25°C时缓慢穿线。由于δ-CD空腔和穿线分子都不对称，因此生成的[2]半罗他烷存在两种取向异构体。二维 1H NMR 光谱和动力学实验表明，较窄边缘（初级羟基）位于 R+ 基团附近的异构体是动力学优选异构体，而另一种异构体则是热力学优选产物。这两种异构体在 25 ℃ 下形成、解离和相互转化的动力学和机理已经确定。
• Synthesis of polyaniline–gold nanocomposites using “grafting from” approach
  作者：Sunil K. Pillalamarri、Frank D. Blum、Massimo F. Bertino

  DOI：10.1039/b419112a

  日期：——

  Polyaniline–gold nanocomposites containing polyaniline nanostructures attached to well-dispersed uniform-size gold nanoparticles were obtained using a surface initiation approach.

  利用表面引发法获得了聚苯胺-金纳米复合材料，其中的聚苯胺纳米结构附着在分散均匀的金纳米粒子上。
• Aryl boronic acids for treating obesity
  申请人：Holmes-Farley Randall Stephen

  公开号：US20050107336A1

  公开（公告）日：2005-05-19

  Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z′ are independently —O—. —NH— or —S—. X is an electron withdrawing group. R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH 2 ) q ] r —NH 2 , halogen, —CF 3 , thiol, ammonium, alcohol, —COOH, —SO 3 H, —OSO 3 H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH 2 ) q ] r —NH 2 is optionally N-alkylated or N,N-dialkylated and —NH 2 in —[NH—(CH 2 ) q ] r —NH 2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated. q is an integer from 2 to about 10 and r is an integer from 1 to about 5. R 1 and R 1′ are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or, taken together, are a C2-C5 substituted or unsubstituted alkylene group optionally comprising an amine linking group [—N + (R 1a )—]. Each R 1 is Structural Formula (I) is preferably —H. R 1a is —H, alkyl, substituted alkyl, phenyl or substituted phenyl. Also disclosed is a method of treating obesity in a subject by administering an effective amount of a compound represented by Structural Formula (I) and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier or diluent.

  本发明公开了一种苯基硼酸化合物，其化学结构式为(I)：其中Ar是取代或未取代的芳基基团，Z和Z'独立地为-O-、-NH-或-S-，X为电子吸引基团，R为取代或未取代的直链烃基团，可选含有一种或多种胺、铵、醚、硫醚或苯基亚基连接基团，Y为-H、胺、-[NH-(CH2)q]r-NH2、卤素、-CF3、硫醇、铵、醇、-COOH、-SO3H、-OSO3H或与R端位共价键合的磷铵基团。-[NH-(CH2)q]r-NH2中的每个-NH-可选地被烷基化或双烷基化，-[NH-(CH2)q]r-NH2中的-NH2可选地被烷基化、双烷基化或三烷基化。其中q为2到约10的整数，r为1到约5的整数。R1和R1'独立地为-H、脂肪基、取代脂肪基、芳基或取代芳基，或者共同为C2-C5取代或未取代的烷基链，可选包括胺连接基[-N+(R1a)-]。在化学结构式(I)中，每个R1最好为-H。R1a为-H、烷基、取代烷基、苯基或取代苯基。本发明还公开了一种通过给予结构式(I)所代表的化合物及其与药学上可接受的载体或稀释剂组成的药物组合物来治疗肥胖症的方法。
• Process for removing bile salts from a patient and alkylated compositions therefor
  申请人：GelTex Pharmaceuticals, Inc.

  公开号：US20010044519A1

  公开（公告）日：2001-11-22

  The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of a salt of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer salt comprises the reaction product of crosslinked polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent.

  本发明涉及一种从需要去除胆盐的患者中去除胆盐的方法和有用的组合物。该方法包括向患者施用一种烷基化和交联聚合物的盐的治疗有效量。烷基化和交联聚合物盐包括交联聚合物的反应产物，或其盐和共聚物，其中具有胺含有重复单元，并与至少一种脂肪族烷基化剂反应。
• Aryl boronate functionalized polymers for treating obesity
  申请人：Holmes-Farley Randall Stephen

  公开号：US20060128663A1

  公开（公告）日：2006-06-15

  Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by one of the following structural formulas: Ar in Structural Formulas (I) and (II) is substituted or unsubstituted; and each Z is —O—, —NH— or —S— and is independently selected. Pharmaceutically acceptable salts of the polymer are also included. The aryl boronate ester, boronamide or boronate thioester can be cleaved to release the corresponding aryl boronic acid. Also disclosed are pharmaceutical compositions comprising the polymers of the present invention and a pharmaceutically acceptable carrier or diluent; and methods of treating a subject for obesity with the polymers of the present invention.

  本发明涉及一种聚合物，其包含一个或多个苯基硼酸酯、硼酰胺或硼酸硫酯基团。苯基硼酸酯、硼酰胺和硼酸硫酯基团由以下结构式之一表示：结构式（I）和（II）中的Ar是取代或未取代的；每个Z是—O—、—NH—或—S—，并且是独立选择的。本发明还包括该聚合物的药学上可接受的盐。芳基硼酸酯、硼酰胺或硼酸硫酯可被裂解以释放相应的芳基硼酸。本发明还涉及包含本发明聚合物和药学上可接受的载体或稀释剂的制药组合物；以及使用本发明聚合物治疗肥胖症的方法。