tert-butyl 2-(5-(naphthalen-2-ylmethoxy)-1H-indol-3-yl)ethylcarbamate | 1422539-00-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: tert-butyl 2-(5-(naphthalen-2-ylmethoxy)-1H-indol-3-yl)ethylcarbamate
• 英文别名: tert-butyl N-[2-[5-(naphthalen-2-ylmethoxy)-1H-indol-3-yl]ethyl]carbamate
• CAS: 1422539-00-1
• 化学式: C₂₆H₂₈N₂O₃
• 分子量: 416.52
• InChiKey: MZCSCQPIFSBHHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  63.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl 2-(5-(naphthalen-2-ylmethoxy)-1H-indol-3-yl)ethylcarbamate 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 以67%的产率得到3-(2-aminoethyl)-5-[(2-naphthyl)methyloxy]indole hydrochloride
  参考文献：
  名称：

  Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase

  摘要：

  Dual function inhibitors targeting phospholipase A(2) (PLA(2)) and leukotriene A(4) hydrolase (LTA(4)H) may balance the arachidonic acid (AA) metabolic network and be used as new anti-inflammatory drugs. In previous study, we discovered multi-target drugs towards the AA metabolic network, among which a dual-target inhibitor (JMC08-4) for human nonpancreatic secretory phospholipase A(2) (hnps-PLA(2)) and human leukotriene A(4) hydrolase (LTA(4)H-h) was found. Based on the structure of compound JMC08-4, new dual-target inhibitors were designed assisted by molecular docking. In this report, a series of 5-hydroxytryptamine compounds were synthesized; and most of these title compounds showed more potent inhibitory activity than compound JMC08-4 in the in vitro bioassay against these two enzymes. The best one inhibited hnps-PLA(2) and LTA(4)H-h with IC50 values of 9.2 +/- 0.5 mu M and 2.4 +/- 1.4 mu M, respectively. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.10.057
• 作为产物：
  描述：

  5-羟基色胺盐酸盐 在 碳酸氢钠 、 caesium carbonate 、 sodium chloride 作用下， 以 氯仿 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 11.0h， 生成 tert-butyl 2-(5-(naphthalen-2-ylmethoxy)-1H-indol-3-yl)ethylcarbamate
  参考文献：
  名称：

  Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase

  摘要：

  Dual function inhibitors targeting phospholipase A(2) (PLA(2)) and leukotriene A(4) hydrolase (LTA(4)H) may balance the arachidonic acid (AA) metabolic network and be used as new anti-inflammatory drugs. In previous study, we discovered multi-target drugs towards the AA metabolic network, among which a dual-target inhibitor (JMC08-4) for human nonpancreatic secretory phospholipase A(2) (hnps-PLA(2)) and human leukotriene A(4) hydrolase (LTA(4)H-h) was found. Based on the structure of compound JMC08-4, new dual-target inhibitors were designed assisted by molecular docking. In this report, a series of 5-hydroxytryptamine compounds were synthesized; and most of these title compounds showed more potent inhibitory activity than compound JMC08-4 in the in vitro bioassay against these two enzymes. The best one inhibited hnps-PLA(2) and LTA(4)H-h with IC50 values of 9.2 +/- 0.5 mu M and 2.4 +/- 1.4 mu M, respectively. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.10.057

文献信息

• Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase
  作者：Hu Meng、Ying Liu、Yujing Zhai、Luhua Lai

  DOI：10.1016/j.ejmech.2012.10.057

  日期：2013.1

  Dual function inhibitors targeting phospholipase A(2) (PLA(2)) and leukotriene A(4) hydrolase (LTA(4)H) may balance the arachidonic acid (AA) metabolic network and be used as new anti-inflammatory drugs. In previous study, we discovered multi-target drugs towards the AA metabolic network, among which a dual-target inhibitor (JMC08-4) for human nonpancreatic secretory phospholipase A(2) (hnps-PLA(2)) and human leukotriene A(4) hydrolase (LTA(4)H-h) was found. Based on the structure of compound JMC08-4, new dual-target inhibitors were designed assisted by molecular docking. In this report, a series of 5-hydroxytryptamine compounds were synthesized; and most of these title compounds showed more potent inhibitory activity than compound JMC08-4 in the in vitro bioassay against these two enzymes. The best one inhibited hnps-PLA(2) and LTA(4)H-h with IC50 values of 9.2 +/- 0.5 mu M and 2.4 +/- 1.4 mu M, respectively. (C) 2012 Elsevier Masson SAS. All rights reserved.