Androstane-3alpha,17-diol | 25126-76-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Androstane-3alpha,17-diol
• 英文别名: (3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol；5α-androstan-3α,17-diol；5α-androstanediol；dihydroandrosterone；androstanediol
• CAS: 25126-76-5
• 化学式: C₁₉H₃₂O₂
• 分子量: 292.462
• InChiKey: CBMYJHIOYJEBSB-UNPXRYTGSA-N

物化性质

• 熔点：
  218-220 °C
• 沸点：
  415.0±18.0 °C(Predicted)
• 密度：
  1.090±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  雄酮 在 Ni⁽⁰⁾ nanoparticles 异丙醇 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以89%的产率得到Androstane-3alpha,17-diol
  参考文献：
  名称：

  Hydrogen-transfer reduction of carbonyl compounds promoted by nickel nanoparticles

  摘要：

  Nickel(0) nanoparticles, generated from nickel(II) chloride, lithium powder and a catalytic amount of 4,4-di-tert-butylbiphenyl (DTBB) in THF at room temperature, have been found to promote the reduction of a variety of ketones and aldehydes by transfer hydrogenation using isopropanol as the hydrogen donor. The nickel nanoparticles were characterised and could be re-utilised with a good performance in the absence of a base. A mechanistic study demonstrates that the reaction proceeds through a dihydride-type mechanism. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.11.093

文献信息

• A GROUP OF CHIMERIC ANTIGEN RECEPTORS (CARS)
  申请人：St. Anna Kinderkrebsforschung

  公开号：EP3632461A1

  公开（公告）日：2020-04-08

  Disclosed is a group of chimeric antigen receptors (CARs) consisting of two, three or four CAR molecules, wherein the members of the group of CARs can be different or identical in their amino acid sequences to one another, and wherein each of the CAR molecules of the group comprise at least a transmembrane domain and an ectodomain comprising either an antigen binding moiety or a binding site to which another polypeptide is able to bind, wherein the another polypeptide comprises an antigen binding moiety; wherein each CAR molecule of the group comprises at least one dimerization domain, wherein this dimerization of a pair of dimerization domains is either induced by a regulating molecule and optionally reduced by another regulating molecule, or occurs in the absence of a regulating molecule and is reduced by a regulating molecule, and wherein the ectodomain of each CAR molecule of the group in its prevalent conformation is free of cysteine amino acid moieties which are able to form intermolecular disulphide bonds with other CAR molecules of the group, respectively, and wherein the antigen binding moieties of the CAR molecules of the group and of the other polypeptides being able to bind to the CAR molecules of the group are either specific for one target antigen or for a non-covalent or a covalent complex of different target antigens.

  公开了一组嵌合抗原受体（CAR），由两个、三个或四个 CAR 分子组成、 其中，该组 CAR 成员的氨基酸序列可以彼此不同或相同，以及 其中该组的每个 CAR 分子至少包括一个跨膜结构域和一个外结构域，该结构域包括抗原结合分子或另一种多肽可与之结合的结合位点，其中另一种多肽包括抗原结合分子； 其中该组的每个 CAR 分子包括至少一个二聚化结构域，一对二聚化结构域的这种二聚化或者由调节分子诱导并可选地被另一个调节分子降低，或者在没有调节分子的情况下发生并被调节分子降低，以及 其中，该组每个 CAR 分子的外结构域在其盛行构象中不含半胱氨酸氨基酸分子，而半胱氨酸氨基酸分子可分别与该组其他 CAR 分子形成分子间二硫键，以及 其中，该组 CAR 分子和能与该组 CAR 分子结合的其他多肽的抗原结合分子对一种靶抗原或不同靶抗原的非共价或共价复合物具有特异性。
• 3-beta-hydroxy-5-alpha-pregnan-20-one for use in medical treatment
  申请人：ASARINA PHARMA AB

  公开号：US11026954B2

  公开（公告）日：2021-06-08

  The present invention provides the steroid compound 3beta-hydroxy-5alpha-pregnan-20-one for use in treatment of Tourette's syndrome, obsessive compulsive disorder and/or gambling disorder, as well as methods for treating said disorders and pharmaceutical compositions for use in treatment of said disorders.

  本发明提供了用于治疗妥瑞症、强迫症和/或赌博障碍的类固醇化合物 3beta-羟基-5α-孕甾-20-酮，以及治疗上述障碍的方法和用于治疗上述障碍的药物组合物。
• 3-beta-hydroxy-5-alpha-pregnan-20-one for use in treatment of essential tremor
  申请人：ASARINA PHARMA AB

  公开号：US11026953B2

  公开（公告）日：2021-06-08

  The present invention provides the steroid compound 3beta-hydroxy-5alpha-pregnan-20-one for use in treatment of essential tremor, as well as methods for treating essential tremor and pharmaceutical compositions for use in treatment of essential tremor.

  本发明提供了用于治疗本质性震颤的类固醇化合物 3beta-羟基-5α-孕甾-20-酮，以及治疗本质性震颤的方法和用于治疗本质性震颤的药物组合物。
• BONE ANABOLIC COMPOUNDS AND METHODS OF USE
  申请人：Anabonix, Inc.

  公开号：EP1404344A2

  公开（公告）日：2004-04-07
• AMINOSTEROID DERIVATIVES AND PROCESS FOR PRODUCING SAME
  申请人：Université Laval

  公开号：EP3464317A1

  公开（公告）日：2019-04-10