1-(3,4-dihydro-2H-1,5-naphthyridin-1-yl)ethanone | 381227-84-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-(3,4-dihydro-2H-1,5-naphthyridin-1-yl)ethanone
• CAS: 381227-84-5
• 化学式: C₁₀H₁₂N₂O
• mdl: MFCD13179440
• 分子量: 176.218
• InChiKey: IYFRMEWOOYTWHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3,4-dihydro-2H-1,5-naphthyridin-1-yl)ethanone 在 硼烷四氢呋喃络合物 、 盐酸 作用下， 以73%的产率得到1-乙基-1,2,3,4-四氢-1,5-萘啶
  参考文献：
  名称：

  Synthesis and conformational properties of N-monoalkyl 1,5-diaza-cis-decalins

  摘要：

  N-Monoalkyl 1,5-diaza-cis-decalins were synthesized in high yield and purity by derivatization of tetrahydronaphthyridine followed by reduction to the saturated system. The position of the conformational equilibrium between the chair-chair inversion forms of a series of four N-monoalkyl of 1,5-diaza-cis-decalins was measured and was directly related to the size of the N-alkyl group. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01344-2
• 作为产物：
  描述：

  1,5-萘啶 在 Rh/Al₂O₃ 氢气 作用下， 20.0 ℃ 、101.33 kPa 条件下， 生成 1-(3,4-dihydro-2H-1,5-naphthyridin-1-yl)ethanone
  参考文献：
  名称：

  Synthesis and conformational properties of N-monoalkyl 1,5-diaza-cis-decalins

  摘要：

  N-Monoalkyl 1,5-diaza-cis-decalins were synthesized in high yield and purity by derivatization of tetrahydronaphthyridine followed by reduction to the saturated system. The position of the conformational equilibrium between the chair-chair inversion forms of a series of four N-monoalkyl of 1,5-diaza-cis-decalins was measured and was directly related to the size of the N-alkyl group. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01344-2

文献信息

• [EN] SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS<br/>[FR] COMPOSÉS DE CYCLOPROPYLE SUBSTITUÉS UTILES À TITRE D'AGONISTES DE GPR119
  申请人：MERCK SHARP & DOHME

  公开号：WO2013074388A1

  公开（公告）日：2013-05-23

  Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

  公开了公式（I）的环丙基化合物及其药学上可接受的盐，用于治疗或预防2型糖尿病和类似疾病。这些化合物可作为G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法。
• SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20140329798A1

  公开（公告）日：2014-11-06

  Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

  本发明公开了式（I）的取代环丙基化合物及其药学上可接受的盐，用于治疗或预防2型糖尿病和类似疾病。该化合物是G蛋白偶联受体GPR-119的激动剂，因此在药物组合物和治疗方法中也有用途。
• NOVEL CEPHEM COMPOUND HAVING CATECHOL OR PSEUDO-CATECHOL STRUCTURE
  申请人：Nishitani Yasuhiro

  公开号：US20140088302A1

  公开（公告）日：2014-03-27

  The present invention provides a novel compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against beta-lactamase producing Gram negative bacteria. Specifically, the present invention provides a compound of the formula (I): wherein each symbol is as defined in the specification, or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.
• US9018224B2
  申请人：——

  公开号：US9018224B2

  公开（公告）日：2015-04-28
• US9334289B2
  申请人：——

  公开号：US9334289B2

  公开（公告）日：2016-05-10