2-propylpentanoic acid 4-oxo-3,4-dihydroquinazolin-2-ylmethyl ester | 1260163-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-propylpentanoic acid 4-oxo-3,4-dihydroquinazolin-2-ylmethyl ester
• 英文别名: (4-oxo-3H-quinazolin-2-yl)methyl 2-propylpentanoate
• CAS: 1260163-35-6
• 化学式: C₁₇H₂₂N₂O₃
• 分子量: 302.373
• InChiKey: DLHWDPWRVIRDAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  67.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(bromomethyl)-4(3H)-quinazolinone 、 sodium valproate 以 乙醇 为溶剂， 反应 48.0h， 以52%的产率得到2-propylpentanoic acid 4-oxo-3,4-dihydroquinazolin-2-ylmethyl ester
  参考文献：
  名称：

  Design, synthesis, and anticonvulsant activity of novel quinazolinone analogues

  摘要：

  A number of 2-substituted and 2,3-disubstituted quinazolinone analogues have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, (1)H NMR, and MS). An evaluation of the anticonvulsant activity of the prepared compounds has indicated that some of them exhibit moderate to significant activity, compared to diazepam and phenobarbital standards.

  DOI：

  10.1007/s00044-010-9465-4

文献信息

• Design, synthesis, and anticonvulsant activity of novel quinazolinone analogues
  作者：Nagwa M. Abdel Gawad、Hanan Hanna Georgey、Riham M. Youssef、Nehad A. El Sayed

  DOI：10.1007/s00044-010-9465-4

  日期：2011.11

  A number of 2-substituted and 2,3-disubstituted quinazolinone analogues have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, (1)H NMR, and MS). An evaluation of the anticonvulsant activity of the prepared compounds has indicated that some of them exhibit moderate to significant activity, compared to diazepam and phenobarbital standards.