AZT-sodium | 106060-86-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: AZT-sodium
• 英文别名: Zidovudine sodium salt；sodium;1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-2-oxopyrimidin-4-olate
• CAS: 106060-86-0
• 化学式: C₁₀H₁₂N₅O₄*Na
• 分子量: 289.226
• InChiKey: XDTLRYHUHKZMKH-HNPMAXIBSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.41
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  99.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  AZT-sodium 在 盐酸 作用下， 以 水 为溶剂， 生成 齐多夫定
  参考文献：
  名称：

  Serendipitous Discovery of a Zidovudine Guanidine Complex: A Superior Process for the Production of Zidovudine

  摘要：

  A superior process for the commercial production of zidovudine (AZT) has been developed. It was discovered that an AZT-guanidine complex formed when a crude zidovudine solution was treated with guanidine. This readily precipitated from protic solvents resulting in the exclusion of impurities and permitted the development of a superior isolation and purification of AZT.

  DOI：

  10.1021/op2000805
• 作为产物：
  描述：

  齐多夫定 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 AZT-sodium
  参考文献：
  名称：

  Serendipitous Discovery of a Zidovudine Guanidine Complex: A Superior Process for the Production of Zidovudine

  摘要：

  A superior process for the commercial production of zidovudine (AZT) has been developed. It was discovered that an AZT-guanidine complex formed when a crude zidovudine solution was treated with guanidine. This readily precipitated from protic solvents resulting in the exclusion of impurities and permitted the development of a superior isolation and purification of AZT.

  DOI：

  10.1021/op2000805

文献信息

• Serendipitous Discovery of a Zidovudine Guanidine Complex: A Superior Process for the Production of Zidovudine
  作者：Bruno K Radatus

  DOI：10.1021/op2000805

  日期：2011.11.18

  A superior process for the commercial production of zidovudine (AZT) has been developed. It was discovered that an AZT-guanidine complex formed when a crude zidovudine solution was treated with guanidine. This readily precipitated from protic solvents resulting in the exclusion of impurities and permitted the development of a superior isolation and purification of AZT.