N-(naphthalen-2-yl)pyridine-3-carboxamide | 75358-97-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(naphthalen-2-yl)pyridine-3-carboxamide
• 英文别名: N-(naphthalen-2-yl)nicotinamide；nicotinic acid-[2]naphthylamide；Nicotinsaeure-[2]naphthylamid；N-naphthalen-2-ylpyridine-3-carboxamide
• CAS: 75358-97-3
• 化学式: C₁₆H₁₂N₂O
• 分子量: 248.284
• InChiKey: RFJYHXJNDAQWSR-UHFFFAOYSA-N

物化性质

• 沸点：
  366.4±15.0 °C(Predicted)
• 密度：
  1.269±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  烟酸 、 2-萘胺 在 silica gel 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 以80%的产率得到N-(naphthalen-2-yl)pyridine-3-carboxamide
  参考文献：
  名称：

  A Convenient One-Pot Synthesis and Nematicidal Activity of Nicotinic Acid Amides

  摘要：

  Seven nicotinic acid amides were synthesized by condensation of nicotinic acid adsorbed on silica gel with different aromatic amines. The synthesized compounds were characterized by H-1 and C-13 NMR and IR spectroscopy and screened for their nematicidal activity against root knot nematode Meloidogyne incognita by egg hatching and mortality test. All compounds exhibited significant nematicidal potential as compared to control. Maximum egg hatching inhibition potential was exhibited by N-(4-bromophenyl)nicotinamide while N-(2,4,5-trichlorophenyl)nicotinamide showed the maximum mortality potential.

  DOI：

  10.1134/s1070428019060150

文献信息

• Clauder; Toldy, Magyar Kemiai Folyoirat, 1950, vol. 56, p. 451
  作者：Clauder、Toldy

  DOI：——

  日期：——
• [EN] SMALL MOLECULE INHIBITORS OF HISTONE DEACTEYLASES<br/>[FR] INHIBITEURS À PETITE MOLÉCULE D'HISTONE DÉSACÉTYLASES
  申请人：NUPOTENTIAL INC

  公开号：WO2013059582A2

  公开（公告）日：2013-04-25

  The disclosure relates to small molecules and methods, compositions, and kits comprising these small molecules. In still another embodiment, the disclosure relates to small molecules that inhibit HDAC activity. In yet another embodiment, the disclosure relates to small molecules for inhibiting the growth of cancer cells. In still another embodiment, the disclosure relates to small molecules for reprogramming a cell.
• A Convenient One-Pot Synthesis and Nematicidal Activity of Nicotinic Acid Amides
  作者：N. Jain、D. Utreja、N. K. Dhillon

  DOI：10.1134/s1070428019060150

  日期：2019.6

  Seven nicotinic acid amides were synthesized by condensation of nicotinic acid adsorbed on silica gel with different aromatic amines. The synthesized compounds were characterized by H-1 and C-13 NMR and IR spectroscopy and screened for their nematicidal activity against root knot nematode Meloidogyne incognita by egg hatching and mortality test. All compounds exhibited significant nematicidal potential as compared to control. Maximum egg hatching inhibition potential was exhibited by N-(4-bromophenyl)nicotinamide while N-(2,4,5-trichlorophenyl)nicotinamide showed the maximum mortality potential.