5-bromo-1-naphthalene-sulfonyl chloride | 50638-04-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-bromo-1-naphthalene-sulfonyl chloride
• 英文别名: <(5-bromo-1-naphthalenyl)sulfonyl>chloride；5-bromo-naphthalenesulfonyl chloride；5-bromnaphthalin-1-sulfochlorid；5-bromo-1-naphthalenesulfonyl chloride；5-bromo-naphthalene-1-sulfonyl chloride；5-Brom-naphthalin-1-sulfonylchlorid；5-Bromonaphthalene-1-sulfonyl chloride
• CAS: 50638-04-5
• 化学式: C₁₀H₆BrClO₂S
• 分子量: 305.579
• InChiKey: UAZSFANIUINLSN-UHFFFAOYSA-N

物化性质

• 沸点：
  394.8±17.0 °C(Predicted)
• 密度：
  1.732±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-bromo-1-naphthalene-sulfonyl chloride 在 吡啶 、 水 、 乙酸酐 、 sodium carbonate 、 氯乙酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 27.5h， 生成 1-<(5-bromo-1-naphthalenyl)sulfonyl>-2,4-imidazolidinedione
  参考文献：
  名称：

  Naphthalenylsulfonyl-hydantoins as aldose reductase inhibitors

  摘要：

  Accumulation of intracellular sorbitol, formed from glucose by aldose reductase, is believed to play an important role in the development of certain chronic complications of diabetes mellitus. Several 1-(naphthalenylsulfonyl)hydantoins inhibit aldose reductase isolated from bovine lens in vitro, and decrease galactitol formation in sciatic nerves of galactosemic rats in vivo. The 5-bromo analogue (entry 12, table I) was found to be the most orally active aldose reductase inhibitor of this series with an ED50 value of 8.1 mg/kg po. The 1-(naphthalenylsulfonyl)-2-thiohydantoin analogues with the exception of entry 11 (table I) which showed good in vivo activity, were either inactive or had only marginal activity.

  DOI：

  10.1016/0223-5234(91)90096-6
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 五氯化磷 作用下， 生成 5-bromo-1-naphthalene-sulfonyl chloride
  参考文献：
  名称：

  Mauzelius, Chemische Berichte, 1887, vol. 20, p. 3401

  摘要：

  DOI：

文献信息

• Naphthalenylsulfonylimidazolidinediones and their thioxo analogs useful
  申请人：American Home Products Corp.

  公开号：US04743611A1

  公开（公告）日：1988-05-10

  Disclosed herein are naphthalenylsulfonylimidazolidinediones and their thioxo analogs and methods for their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

  本文披露了萘磺酰基咪唑二酮及其硫代类似物以及它们的制备方法。这些化合物是新型的醛糖还原酶抑制剂，可用于治疗或预防糖尿病并发症。
• .omega.-(Arylsulfonamido)-alkylamine
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US04069254A1

  公开（公告）日：1978-01-17

  .omega.-(Arylsulfonamido)-alkylamines having the formula R'-SO.sub.2 NH(CH.sub.2).sub.n R I wherein R represents an amino group which can be acylated; R' represents phenyl or naphthyl which can be substituted by halogen or lower alkyl; and n represents an integer from 5 - 8 are effective in inhibiting blood platelet aggregation.

  具有以下公式的.omega.-(芳基磺酰胺基)-烷基胺类化合物 R'-SO.sub.2 NH(CH.sub.2).sub.n R I，其中 R 代表可酰化的氨基团；R' 代表苯基或萘基，可被卤素或较低烷基取代；n 代表5-8之间的整数，对抑制血小板聚集有效。
• Thiazolidine derivatives for the treatment of psoriasis
  申请人：Regents of the University of California

  公开号：US05594015A1

  公开（公告）日：1997-01-14

  A new medical use for certain thiazolidine derivatives is disclosed. Specifically, treatment of hyperproliferative epithelial cell conditions, such as psoriasis, by administration of thiazolidinediones or 5'-aryl substituted thiazolidine derivatives is described. Appropriate chemical structures, synthetic reactions, formulations, routes of administration and dosages are included.

  本文披露了某些噻唑烷衍生物的新医疗用途。具体来说，描述了通过给予噻唑烷二酮或5'-芳基取代的噻唑烷衍生物治疗过度增生的上皮细胞病症，如牛皮癣。包括适当的化学结构、合成反应、制剂、给药途径和剂量。
• Naphthalenylsulfonylimidazolidinediones and their thioxo analogs
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0251784A2

  公开（公告）日：1988-01-07

  The invention comprises naphthalenylsulfonylimidazolidinediones of formula (I) wherein R⁴, R⁵, R⁶ and R⁷ are hydrogen, halogen, trifluoromethyl, methoxy or dimethylamino and X is oxygen or sulfur and the pharmaceutically acceptable salts thereof, and methods for their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications. Pharmaceutical compositions containing the compounds and methods for manufacturing same are also included in the invention.

  本发明包括式 (I) 的萘基磺酰亚胺唑烷二酮，其中 R⁴、R⁵、R⁶ 和 R⁷ 是氢、卤素、三氟甲基、甲氧基或二甲基氨基，X 是氧或硫及其药学上可接受的盐，以及它们的制备方法。 这些化合物是新型醛糖还原酶抑制剂，可用于治疗或预防糖尿病并发症。 本发明还包括含有这些化合物的药物组合物及其生产方法。
• Horner, Leopold; Flemming, Hans-Wolfram, Phosphorus and Sulfur and the Related Elements, 1984, vol. 19, p. 345 - 362
  作者：Horner, Leopold、Flemming, Hans-Wolfram

  DOI：——

  日期：——