(R)-1-ethyl-2,2-dimethylpropylamine hydrochloride | 158849-15-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (R)-1-ethyl-2,2-dimethylpropylamine hydrochloride
• 英文别名: 1(R)-Ethyl-2,2-dimethylpropylamine Hydrochloride；(3R)-2,2-dimethylpentan-3-amine hydrochloride；(3R)-2,2-dimethylpentan-3-amine;hydrochloride
• CAS: 158849-15-1
• 化学式: C₇H₁₇N*ClH
• 分子量: 151.68
• InChiKey: RPECBLQCZOIIMC-FYZOBXCZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.19
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,2-二甲基-3-戊酮 生成 (R)-1-ethyl-2,2-dimethylpropylamine hydrochloride
  参考文献：
  名称：

  WO2007/71393

  摘要：

  公开号：

文献信息

• [EN] PROCESS FOR PURIFICATION OF (R,R)-(1-ALKYL-2,2-DIMETHYLPROPYL)-(1-PHENYLALKYL)-AMINES<br/>[FR] PROCÉDÉ DE PURIFICATION DE (R,R)-(1-ALKYL-2,2-DIMÉTHYLPROPYL)-(1-PHÉNYLALKYL)-AMINES
  申请人：S & I OPHTHALMIC LLC

  公开号：WO2017199228A1

  公开（公告）日：2017-11-23

  The present invention relates to a simple economical process for the purification of an acid addition salt of a compound of Formula (III) contaminated with an acid addition salt of a compound of Formula (III'), which comprises washing at least once the addtion salt of the compound of Formula III with an organic solvent capable of removing the acid addition salt of the compound of Formula III' to obtain the acid addition salt of the compound of Formula III in chiral purity of greater than 99.5 % and chromatographic purity of greater than 99 %.

  本发明涉及一种简单经济的方法，用于纯化公式（III）化合物的酸加成盐，该盐受到公式（III'）化合物的酸加成盐的污染。该方法包括使用有机溶剂至少一次洗涤公式III化合物的加成盐，有机溶剂能够去除公式III'化合物的酸加成盐，从而获得具有手性纯度大于99.5％和色谱纯度大于99％的公式III化合物的酸加成盐。
• Sulphonamidoaniline Derivatives Being Janus Kinase Inhibitors
  申请人：Capraro Hans-Georg

  公开号：US20080261973A1

  公开（公告）日：2008-10-23

  The invention relates to sulphonamidoanilines of formula I, wherein A is N or CH, W, X, Y and Z are N or CH under the proviso that at least one of the three symbols W, X and Y represent CH, R 1 represents NR 4 R 5 or OR 4 , wherein R 4 represents optionally substituted alkyl, optionally substituted cycloalkyl optionally comprising one or two nitrogen or oxygen atoms, or substituted aryl, and R 5 represents hydrogen or unsubstituted or substituted alky, or R 4 and R 5 together with the nitrogen to which they are attached represent an optionally substituted five- or six-membered nitrogen containing monocyclic ring, an optionally substituted nitrogen containing fully saturated bicyclic ring, or an spirocyclic fully saturated ring system containing one or two nitrogen atoms, R 2 is hydrogen, lower alkenyl or alkyl, R 3 is alkyl which is unsubstituted or mono-, di- or trisubstituted by halogen; alkenyl or aryl, and their salts; processes for their preparation, their application in the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of diseases, a method for the treatment of such a disease and the use of such a compound—alone or in combination with one or more other pharmaceutically active compounds—for the manufacture of a pharmaceutical preparation for the treatment of a proliferative disease.

  本发明涉及式I的磺酰胺苯胺，其中A为N或CH，W、X、Y和Z为N或CH，但至少三个符号W、X和Y中的一个代表CH，R1代表NR4R5或OR4，其中R4代表可选取代的烷基，可选取代的环烷基，可包含一个或两个氮或氧原子的取代芳基；R5代表氢或未取代或取代的烷基，或R4和R5连同它们所连接的氮表示一个可选取代的五元或六元含氮单环环，一个可选取代的含氮完全饱和的双环环，或一个含有一或两个氮原子的螺环完全饱和环系统，R2为氢、低碳烯基或烷基，R3为未取代或单、二、三取代的卤素的烷基、烯基或芳基，以及它们的盐；它们的制备方法，它们在治疗人体或动物体中的应用，使用它们-独自或与一个或多个其他药理活性化合物结合-治疗疾病的方法，以及使用这种化合物-独自或与一个或多个其他药理活性化合物结合-制造治疗增殖性疾病的药物制剂。
• ANTIHERPES PEPTIDOMIMETIC COMPOUNDS
  申请人：BOEHRINGER INGELHEIM (CANADA) LTD.

  公开号：EP0800512B1

  公开（公告）日：2000-01-05
• HERPES RIBONUCLEOTIDE REDUCTASE INHIBITORS
  申请人：BOEHRINGER INGELHEIM (CANADA) LTD.

  公开号：EP0837845B1

  公开（公告）日：2001-11-28
• SULPHONAMIDOANILINE DERIVATIVES BEING JANUS KINASES INHIBITORS
  申请人：Novartis AG

  公开号：EP1966210A2

  公开（公告）日：2008-09-10