N-ethoxy-urea | 763-96-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-ethoxy-urea
• 英文别名: N-ethoxyurea；ethoxy-urea；O-Aethyl-N-carbamoyl-hydroxylamin；Aethoxy-harnstoff；1-ethoxyurea；Harnstoff-O-athylather；ethoxyurea
• CAS: 763-96-2
• 化学式: C₃H₈N₂O₂
• 分子量: 104.109
• InChiKey: DTTVNCZEOYSFFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-ethoxy-urea 在 次氯酸叔丁酯 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以98%的产率得到N-chloro-N-ethoxyurea
  参考文献：
  名称：

  Geminal systems. 50. Synthesis and alcoholysis of N-acyloxy-N-alkoxy derivatives of ureas, carbamates, and benzamides

  摘要：

  Procedures were developed for the synthesis of N-acyloxy-N-alkoxy derivatives of ureas, carbamates, and benzamides by the reactions of the corresponding N-alkoxy-N-chloro derivatives with sodium carboxylates in MeCN. N-Chloro-N-etlioxy-p-toluenesulfonamide was inert in this reaction. Alcoholysis of N-acyloxy-N-alkoxy derivatives of ureas, carbamates, and tert-alkylamines afforded the corresponding N,N-dialkoxy derivatives, whereas alcoholysis of N-acetoxy-N-ethoxybenzamide gave rise to alkyl benzoates.

  DOI：

  10.1023/b:rucb.0000011887.40529.b0
• 作为产物：
  描述：

  ethyl N-ethoxycarbamate 在 氨 、 水 作用下， 生成 N-ethoxy-urea
  参考文献：
  名称：

  Runti; Deghenghi, 1952, vol. <2> 22/23, p. 185,191

  摘要：

  DOI：

文献信息

• Jones; Major, Journal of the American Chemical Society, 1927, vol. 49, p. 1539
  作者：Jones、Major

  DOI：——

  日期：——
• Single-stage synthesis of 3-hydroxy- and 3-alkoxy-5-arylimidazolidine-2,4-diones by reaction of arylglyoxal hydrates with N-hydroxy- and N-alkoxyureas
  作者：Vasiliy G. Shtamburg、Viktor V. Shtamburg、Andrey A. Anishchenko、Roman I. Zubatyuk、Aleksander V. Mazepa、Eugene A. Klotz、Svetlana V. Kravchenko、Remir G. Kostyanovsky

  DOI：10.1007/s10593-015-1735-0

  日期：2015.6

  Arylglyoxal hydrates interact with N-alkoxyureas and N-hydroxyurea in acetic acid with selective formation of 3-alkoxy-5-arylimidazolidine-2,4-diones and 5-aryl-3-hydroxyimidazolidine-2,4-diones, respectively. The structures of 3-methoxy-5-phenylimidazolidine-2,4-dione, 3-ethoxy-5-phenylimidazolidine-2,4-dione, and 3-butoxy-5-(4-chlorophenyl)imidazolidine-2,4-dione were studied by X-ray structural analysis.
• Die photochemische zersetzung von carbamidsäureazid in aliphatischen alkoholen
  作者：Richard Kreher、Gesche H. Berger

  DOI：10.1016/s0040-4039(00)89962-1

  日期：1965.1
• Runti; Deghenghi, 1952, vol. <2> 22/23, p. 185,190
  作者：Runti、Deghenghi

  DOI：——

  日期：——
• Geminal systems. 50. Synthesis and alcoholysis of N-acyloxy-N-alkoxy derivatives of ureas, carbamates, and benzamides
  作者：V. G. Shtamburg、E. A. Klots、A. P. Pleshkova、V. I. Avramenko、S. P. Ivonin、A. V. Tsygankov、R. G. Kostyanovsky

  DOI：10.1023/b:rucb.0000011887.40529.b0

  日期：2003.10

  Procedures were developed for the synthesis of N-acyloxy-N-alkoxy derivatives of ureas, carbamates, and benzamides by the reactions of the corresponding N-alkoxy-N-chloro derivatives with sodium carboxylates in MeCN. N-Chloro-N-etlioxy-p-toluenesulfonamide was inert in this reaction. Alcoholysis of N-acyloxy-N-alkoxy derivatives of ureas, carbamates, and tert-alkylamines afforded the corresponding N,N-dialkoxy derivatives, whereas alcoholysis of N-acetoxy-N-ethoxybenzamide gave rise to alkyl benzoates.