dimethyl(2-oxooctyl)phosphonate | 61408-88-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: dimethyl(2-oxooctyl)phosphonate
• 英文别名: 2-oxooctylphosphonic acid dimethyl ester；dimethyl 2-oxo-octanylphosphonate；Dimethyl (2-oxooctyl)phosphonate；1-dimethoxyphosphoryloctan-2-one
• CAS: 61408-88-6
• 化学式: C₁₀H₂₁O₄P
• 分子量: 236.248
• InChiKey: ZFMWNFNQTNSEAD-UHFFFAOYSA-N

物化性质

• 沸点：
  314.0±25.0 °C(Predicted)
• 密度：
  1.038±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  dimethyl(2-oxooctyl)phosphonate 在 N-溴代丁二酰亚胺(NBS) 、 sodium hydride 作用下， 以 四氢呋喃 、 四氯化碳 为溶剂， 反应 3.5h， 生成 (E)-2-bromoundec-3-en-5-one
  参考文献：
  名称：

  A simple synthesis of dihydrojasmonea

  摘要：

  DOI：

  10.1016/s0040-4039(00)81430-6
• 作为产物：
  描述：

  庚酸甲酯 、 甲基膦酸二甲酯 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.67h， 以91%的产率得到dimethyl(2-oxooctyl)phosphonate
  参考文献：
  名称：

  [EN] GAMMA LACTAMS AS PROSTAGLANDIN AGONISTS AND USE THEREOF
  [FR] GAMMA LACTAMES UTILISES EN TANT QU'AGONISTES DE LA PROSTAGLANDINE ET LEUR UTILISATION

  摘要：

  公开号：

  WO2003103604A3

文献信息

• Catechol derivatives and pharmaceutical compositions thereof for
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04618627A1

  公开（公告）日：1986-10-21

  A catechol derivative represented by the formula ##STR1## The compounds of this invention are useful for the prophylaxis and treatment for various allergic diseases, ischemic heart diseases and inflammations caused by slow reacting substance of anaphylaxis (SRS-A), since the compounds inhibit very potently the formation and release of SRS-A.

  这种化合物的衍生物由以下公式表示 ##STR1## 本发明的化合物对于预防和治疗各种过敏疾病、缺血性心脏病以及由缓慢反应性过敏原质(SRS-A)引起的炎症非常有用，因为这些化合物能够强力抑制SRS-A的形成和释放。
• Novel lactones of cyclopentanols
  申请人：Roussel Uclaf

  公开号：US04279919A1

  公开（公告）日：1981-07-21

  Novel lactones of the formula ##STR1## wherein the dotted line indicates the optional presence of a second bond, A is a single bond or --CH.sub.2 --CH.sub.2 --, R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.6 is --OR.sub.A ', R.sub.A ' is selected from the group consisting of hydrogen, tetrahydropyranyl, alkyl of 1 to 3 carbon atoms and ##STR2## R.sub.A " is selected from the group consisting of alkyl of 1 to 3 carbon atoms optionally substituted with carboxyl and phenyl optionally substituted with a member of the group consisting of carboxyl, free hydroxyl, hydroxyl protected with an acyl of 2 to 4 carbon atoms and hydroxyl protected with an easily hydrolyzable group and R and R.sub.6 together form a keto group, R.sub.7 is --CH.sub.2).sub.m.sbsb.A --CH.sub.3, m.sub.A is 3,4,5 or 6 and R.sub.6 and R.sub.7 taken together form .dbd.CH--(CH.sub.2).sub.n.sbsb.A --CH.sub.3, n.sub.A is 2,3,4 or 5 and the wavy lines indicate that the bonds are in one or the other of the possible configurations and when A is a simple bond, the bond between the cyclopentane ring and the oxygen is in the .alpha.-position having hypotensive activity and the wavy lines represent a paired configuration selected from the group consisting of .alpha.,.beta. and .beta.,.alpha. and mixtures thereof and novel processes and intermediates for their preparation.

  该专利描述了一种新型内酯的化学结构和制备方法。
• 11-Deoxy PGE.sub.2 compounds
  申请人：The Upjohn Company

  公开号：US04130721A1

  公开（公告）日：1978-12-19

  11-Deoxyprostaglandin E and F type compounds, i.e. prostaglandin E and F type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.

  11-去氧前列腺素E和F型化合物，即将11-羟基团替换为氢的前列腺素E和F型化合物被披露，以及制备它们的方法。这些化合物可用于各种药理目的，包括抗溃疡、抑制血小板聚集、增加鼻腔通畅、催产术和伤口愈合。
• .beta.-Lactones of 2-hydroxy-cyclopentanecarboxylic acid
  申请人：Roussel Uclaf

  公开号：US04221809A1

  公开（公告）日：1980-09-09

  Novel lactones of the formula ##STR1## wherein the dotted line indicates the optional presence of a second bond, A is a single bond or --CH.sub.2 --CH.sub.2 --, R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.6 is --OR'.sub.A, R'.sub.A is selected from the group consisting of hydrogen, tetrahydropyranyl, alkyl of 1 to 3 carbon atoms and ##STR2## R".sub.A is selected from the group consisting of alkyl of 1 to 3 carbon atoms optionally substituted with carboxyl and phenyl optionally substituted with a member of the group consisting of carboxyl, free hydroxyl, hydroxyl protected with an acyl of 2 to 4 carbon atoms and hydroxyl protected with an easily hydrolyzable group and R and R.sub.6 together form a keto group, R.sub.7 is --(CH.sub.2)m.sub.A --CH.sub.3, m.sub.A is 3,4,5 or 6 and R.sub.6 and R.sub.7 taken together form .dbd. CH--(CH.sub.2)n.sub. A --CH.sub.3 n.sub.A is 2,3,4 or 5 and the wavy lines indicate that the bonds are in one or the other of the possible configurations and when A is a simple bond, the bond between the cyclopentane ring and the oxygen is in the .alpha.-position having hypotensive activity and novel processes and intermediates for their preparation.

  公式为##STR1##的新型内酯，其中虚线表示第二键的可选存在，A是单键或--CH.sub.2 --CH.sub.2 --，R选自氢、1到4个碳原子的烷基和2到4个碳原子的烯基和炔基组成的群，R.sub.6是--OR'.sub.A，R'.sub.A选自氢、四氢吡喃基、1到3个碳原子的烷基和##STR2##，R".sub.A选自1到3个碳原子的烷基，可选择地取代羧基和苯基，可选择地取代羧基、游离羟基、用2到4个碳原子的酰基保护的羟基和用易水解基团保护的羟基和R和R.sub.6一起形成酮基，R.sub.7是--(CH.sub.2)m.sub.A --CH.sub.3，m.sub.A为3,4,5或6，R.sub.6和R.sub.7一起形成.dbd. CH--(CH.sub.2)n.sub. A --CH.sub.3，n.sub.A为2,3,4或5，波浪线表示键处于可能的两种配置之一，当A是简单键时，环戊烷环和氧之间的键处于α-位置，具有降压活性，以及其制备的新型过程和中间体。
• 16-Methyl prost-5-en-13-ynoic acid derivatives
  申请人：Carlo-Erba S.p.A.

  公开号：US04041064A1

  公开（公告）日：1977-08-09

  16S and 16R methyl 13, 14 dehydro PGE.sub.2 compounds have been prepared.

  已经制备了16S和16R甲基13,14去氢PGE.sub.2化合物。