1-N-(tert-butylamino)-2-methyl-2-propene | 119353-28-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-N-(tert-butylamino)-2-methyl-2-propene
• 英文别名: N-tert-Butyl-N-(2-methyl-2-propenyl)amine；N-(tert-butyl)-2-methylprop-2-en-1-amine；N-tert-butyl-N-methallylamine；N-tert-Butyl-2-methylprop-2-en-1-amine
• CAS: 119353-28-5
• 化学式: C₈H₁₇N
• 分子量: 127.23
• InChiKey: YJZKHZXHJJZFKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-N-(tert-butylamino)-2-methyl-2-propene 在 [(Cp^TMS)2Lu(μ-Me)]2 、 potassium carbonate 作用下， 以 氘代苯 、 乙腈 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  Investigations concerning the organolanthanide and group 3 metallocene-catalyzed cyclization–functionalization of nitrogen-containing dienes

  摘要：

  Organolanthanide catalyzed cyclization-silylation of nitrogen-containing polyunsaturated systems allows access to core structures commonly found in naturally occurring alkaloids. Nitrogen-containing dienes with various substitution patterns were investigated. The method was most successful for substrates with terminal alkenes. Cyclization upon pendant 1,1-disubstituted olefins was not realized under various conditions. Interestingly, sterically hindered sulfonamides, which were previously believed to render the catalyst inactive, were actually compatible with the catalyst, thus affording the cyclized products after prolonged reaction times. Variations using fused ring systems were also investigated. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.01.048
• 作为产物：
  描述：

  N-(2-methylpropylidene)-2-methyl-2-propanamine 在 sodium tetrahydroborate 、 N-溴代丁二酰亚胺(NBS) 、 potassium tert-butylate 作用下， 以 四氯化碳 、 乙醚 、 乙醇 为溶剂， 反应 13.0h， 生成 1-N-(tert-butylamino)-2-methyl-2-propene
  参考文献：
  名称：

  Kimpe, Norbert de; Stanoeva, Elena; Verhe, Roland, Synthesis, 1988, # 8, p. 587 - 592

  摘要：

  DOI：

文献信息

• Asymmetric Palladium-Catalyzed Alkene Carboamination Reactions for the Synthesis of Cyclic Sulfamides
  作者：Zachary J. Garlets、Kaia R. Parenti、John P. Wolfe

  DOI：10.1002/chem.201600887

  日期：2016.4.18

  The synthesis of cyclic sulfamides by enantioselective Pd‐catalyzed alkene carboamination reactions between N‐allylsulfamides and aryl or alkenyl bromides is described. High levels of asymmetric induction (up to 95:5 e.r.) are achieved using a catalyst composed of [Pd2(dba)3] and (S)‐Siphos‐PE. Deuterium‐labelling studies indicate the reactions proceed through syn‐aminopalladation of the alkene and

  描述了通过N-烯丙基磺酰胺与芳基或烯基溴之间的对映选择性 Pd 催化的烯烃碳胺化反应合成环状磺酰胺。使用由 [Pd 2 (dba) 3 ] 和 ( S )-Siphos-PE 组成的催化剂实现了高水平的不对称感应（高达 95:5 er）。氘标记研究表明反应通过烯烃的顺式氨基钯化进行，并表明控制顺式与反式氨基钯化途径对于不对称诱导非常重要。
• Enantioselective Palladium-Catalyzed Arylborylation/Cyclization of Alkenes to Access Boryl-Functionalized Heterocyclic Compounds Containing Quaternary Stereogenic Centers
  作者：Xingfeng Bai、Wenrui Zheng、Shaozhong Ge、Yixin Lu

  DOI：10.1021/acs.orglett.2c01082

  日期：2022.4.29

  Asymmetric palladium-catalyzed arylboration/cyclization of both nonactivated and activated alkenes with B2pin2 was developed. A wide range of N-allyl-o-iodobenzamides and o-iodoacryanilides reacted with B2pin2 to afford borylated 3,4-dihydroisoquinolinones and oxindoles, respectively, in high yields with high enantioselectivities. The synthetic utility of this enantioselective protocol was highlighted

  开发了非活化和活化烯烃与 B 2 pin 2的不对称钯催化芳基硼化/环化。范围广泛的N-烯丙基-邻碘苯甲酰胺和邻碘丙烯酰苯胺与 B 2 pin 2反应，分别以高产率和高对映选择性得到硼化 3,4-二氢异喹啉酮和羟吲哚。通过合成各种手性 3,4-二氢异喹啉酮和含有季立体碳中心的羟吲哚衍生物，包括对映体富集的罗氏抗癌剂 ( S )-RO4999200，突出了该对映选择性方案的合成效用。
• Photoredox catalysis in the synthesis of γ- and δ-lactams from <i>N</i>-alkenyl trichloro- and dichloroacetamides
  作者：Gisela Trenchs、Faïza Diaba

  DOI：10.1039/d2ob00276k

  日期：——

  The first blue light-mediated synthesis of γ- and δ-lactams from trichloroacetamides is reported in the presence of fac-Ir(ppy)₃ under an air atmosphere.

  在空气氛围下，使用fac-Ir（ppy）₃作为催化剂，报道了从三氯乙酰胺合成γ-和δ-内酰胺的首个蓝光介导的合成方法。
• 10a-Azalide Compound
  申请人：Sugimoto Tomohiro

  公开号：US20090281292A1

  公开（公告）日：2009-11-12

  [Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as against conventional erythromycin sensitive bacteria. [Solution]: A novel 10a-azalide compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof, or an intermediate for the preparation of the same. The compound of the present invention has superior antibacterial activity against Hemophilus influenzae , erythromycin resistant pneumococci and the like, and therefore, the compound can be used as a therapeutic agent of infectious diseases.

  【目标】提供一种具有新结构的化合物，对流感嗜血杆菌和红霉素耐药菌（例如耐药肺炎球菌和链球菌）以及传统的红霉素敏感菌具有有效作用。 【解决方案】本发明提供了一种新型10a-氮杂环十六元化合物，其化学式为（I），其药学上可接受的盐或其溶剂化物，或其制备的中间体。该化合物对流感嗜血杆菌、红霉素耐药性肺炎球菌等具有卓越的抗菌活性，因此可以作为治疗传染病的药物。
• Intramolecular Cobalt/Visible Light Cocatalyzed Reductive Coupling of Unactivated Arenes with Unactivated Alkenes
  作者：Jianpeng Cai、Guohui Zeng、Kai Jiang、Hui Luo、Biaolin Yin

  DOI：10.1021/acs.orglett.3c03978

  日期：2024.1.12

  A protocol for the intramolecular reductive coupling of unactivated arenes with unactivated alkenes has been developed with the aid of a cooperative visible light/cobalt catalytic system. This coupling is achieved via radical cascade cyclization using amines as terminal reducing reagents and water as the main hydrogen source. In their form, readily available N-allyl benzamides are converted to the

  借助协同可见光/钴催化系统，开发了未活化芳烃与未活化烯烃的分子内还原偶联方案。这种偶联是通过使用胺作为末端还原剂和水作为主要氢源的自由基级联环化来实现的。在它们的形式中，容易获得的N-烯丙基苯甲酰胺可以以中等至优异的产率转化为相应的螺环己二烯-内酰胺或β-苯乙胺类似物。