N,N-Diethyl-thioacetamid | 21010-22-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代酰胺
• 英文名称: N,N-Diethyl-thioacetamid
• 英文别名: N,N-diethylthioacetamide；N,N-diethylethanethioamide
• CAS: 21010-22-0
• 化学式: C₆H₁₃NS
• mdl: MFCD00046867
• 分子量: 131.242
• InChiKey: HAJDGVMDCJWONQ-UHFFFAOYSA-N

物化性质

• 沸点：
  102-105 °C(Press: 4.5 Torr)
• 密度：
  0.938±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  35.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-噻吩甲醇 、 N,N-Diethyl-thioacetamid 在 三叔丁基膦 、 potassium tert-butylate 、 nickel diacetate 作用下， 以 1,4-二氧六环 、 甲苯 为溶剂， 反应 12.0h， 以90%的产率得到N,N-diethyl-3-(thiophen-3-yl)propanethioamide
  参考文献：
  名称：

  氢自动转移策略对伯醇进行镍催化的硫代酰胺，酰胺和酯的C-烷基化反应

  摘要：

  Ni（OAc）2和P（t-Bu）3的简单催化剂使硫代乙酰胺和伯乙酰胺与醇的选择性C-烷基化首次实现。硫代酰胺，酰胺和叔丁基酯的单烷基化以极高的收率（> 95％）发生。机理研究表明，反应通过氢自动转移途径进行。

  DOI：

  10.1039/d0cc06468h
• 作为产物：
  描述：

  N,N-二乙基乙酰胺 在 劳森试剂 作用下， 以 乙二醇二甲醚 为溶剂， 反应 0.67h， 以90%的产率得到N,N-Diethyl-thioacetamid
  参考文献：
  名称：

  Nishio, Takehiko; Okuda, Norikazu; Kashima, Choji, Journal of the Chemical Society. Perkin transactions I, 1991, # 1, p. 141 - 143

  摘要：

  DOI：

文献信息

• NOVEL 8-HYDROXYQUINOLINE ACETAMIDE COMPOUND, 8-HYDROXY QUINOLINE THIOAMIDE COMPOUND AND USE THEREOF
  申请人：CHANG Suk Kyu

  公开号：US20080044913A1

  公开（公告）日：2008-02-21

  Disclosed are a novel 8-hydroxyquinoline acetamide compound, an 8-hydroxyquinoline thioamide and use thereof. More specifically, disclosed are a novel 8-hydroxyquinoline thioamide compound suitable for use as a selective chemodosimeter that shows considerably high detection sensitivity to mercury ions, an 8-hydroxyquinoline acetamide compound as an intermediate thereof, preparation thereof, and a chemodosimeter for mercury ion-selective detection, the chemodosimeter comprising the 8-hydroxyquinoline thioamide compound. The compounds as disclosed herein exhibit considerably effective fluorescence specificity of an off-on type, detect a micromole of mercury ions from chemical and biological aqueous systems, and allow 100% desulfurization within 5 minutes, thus being considerably useful in the chemical industry.

  本文披露了一种新型的8-羟基喹啉乙酰胺化合物、一种8-羟基喹啉硫代酰胺及其用途。更具体地，披露了一种新型的8-羟基喹啉硫代酰胺化合物，适用于作为选择性化学传感器，对汞离子具有相当高的检测灵敏度，以及作为其中间体的8-羟基喹啉乙酰胺化合物、其制备方法，并且一种用于汞离子选择性检测的化学传感器，该化学传感器包括8-羟基喹啉硫代酰胺化合物。本文披露的化合物表现出相当有效的荧光特异性，可检测化学和生物水系中的微摩尔汞离子，并在5分钟内实现100%的脱硫，因此在化工行业中具有相当大的用途。
• KETONE OR OXIME COMPOUND, AND HERBICIDE
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20170347647A1

  公开（公告）日：2017-12-07

  There is provided novel agricultural chemicals, in particular herbicides. A ketone or oxime compound or a salt thereof of Formula (1): wherein B is a ring of any one of B-1, B-2, or B-3, Q is an oxygen atom, a sulfur atom, NOR 7 , etc., R 6 is a hydrogen atom, C 1-6 alkyl, etc., R 7 is a hydrogen atom, C 1-6 alkyl, etc., R 8a , R 8b , R 9a , R 9b , R 10 , R 11 , R 12 , R 13 , and R 14 are each independently a hydrogen atom, C 1-6 alkyl, etc., m is an integer of 1 or 2, n is an integer of 0, 1 or 2; and a herbicide including the compound or salt thereof.

  提供了新型农业化学品，特别是除草剂。化合物或其盐的酮或肟化合物的公式（1）：其中B是B-1、B-2或B-3中的任意一个环，Q是氧原子、硫原子、NOR7等，R6是氢原子、C1-6烷基等，R7是氢原子、C1-6烷基等，R8a、R8b、R9a、R9b、R10、R11、R12、R13和R14各自独立地是氢原子、C1-6烷基等，m是1或2的整数，n是0、1或2的整数；以及包括该化合物或其盐的除草剂。
• Fused heterocycle derivative
  申请人：Sawada Takashi

  公开号：US20090239853A1

  公开（公告）日：2009-09-24

  A fused heterocycle derivative represented by the general formula (I): (wherein R 1 represents optionally substituted lower alkyl, or the like; R 2 represents an optionally substituted aliphatic heterocyclic group, or the like; R 3 represents —C(=Z)NR 5 R 6 (wherein R 5 and R 6 represent optionally substituted lower alkyl, or the like, and Z represents an oxygen atom or the like), or the like; n represents an integer of 1 to 3; and W represents C—R 5 (wherein R 5 represents a hydrogen atom or the like)) or a pharmaceutically acceptable salt thereof, and the like are provided.

  提供一种由通式（I）表示的融合杂环衍生物：（其中R1代表可选取代的低碳基等；R2代表可选取代的脂肪族杂环基等；R3代表—C（=Z）NR5R6（其中R5和R6代表可选取代的低碳基等，Z代表氧原子等）等；n代表1到3的整数；W代表C—R5（其中R5代表氢原子等）或类似物的药物可接受的盐等。
• Phenyl-and pyridylpiperidine-derivatives as modulators of glucose metabolism
  申请人：Jones M. Robert

  公开号：US20070066590A1

  公开（公告）日：2007-03-22

  The present invention relates to certain substituted aryl and heteroaryl derivatives as shown in Formula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

  本发明涉及某些取代芳基和杂环芳基衍生物，如式（Ia）所示，它们是代谢调节剂。因此，本发明的化合物在预防或治疗代谢性疾病及其并发症，如糖尿病和肥胖症方面是有用的。
• 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
  申请人：Teegarden Bradley

  公开号：US20110105456A1

  公开（公告）日：2011-05-05

  The present invention relates to certain 3-phenyl-pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT 2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT 2A serotonin receptor mediated disorders in combination with other pharmaceutical agents administered separately or together.

  本发明涉及一些3-苯基吡唑衍生物(Ia式)及其药物组成物，该药物组成物调节5-HT2A血清素受体的活性。该化合物及其药物组成物适用于治疗血小板聚集、冠状动脉疾病、心肌梗死、短暂性脑缺血发作、心绞痛、中风、心房颤动、减少血栓形成的风险、哮喘或其症状、激动或症状、行为障碍、药物诱导的精神病、兴奋性精神病、Gilles de la Tourette综合征、躁狂障碍、器质性或NOS精神病、精神障碍、急性精神分裂症、慢性精神分裂症、NOS精神分裂症及相关疾病、睡眠障碍、糖尿病相关疾病、进行性多发性白质脑病等治疗方法。本发明还涉及用于治疗5-HT2A血清素受体介导的疾病的方法，该方法与其他单独或联合使用的药物剂量组合使用。

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