4-tert-Butyl-4,5,6,7-tetrahydro-imidazo<4,5-c>pyridin | 4875-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 4-tert-Butyl-4,5,6,7-tetrahydro-imidazo<4,5-c>pyridin
• 英文别名: 7-tert-Butyl-4,5,6,7-tetrahydro-imidazo<5,4-c>pyridin；4-tert-butyl-4,5,6,7-tetrahydro-1(3)H-imidazo[4,5-c]pyridine；4-tert-butyl-3H,4H,5H,6H,7H-imidazo[4,5-c]pyridine；4-tert-butyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
• CAS: 4875-38-1
• 化学式: C₁₀H₁₇N₃
• 分子量: 179.265
• InChiKey: KTKYCUSNPAYVFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  40.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF
  申请人：Epizyme, Inc.

  公开号：US20200039998A1

  公开（公告）日：2020-02-06

  The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.