carbonic acid bis-(2-{4-[3-(2-chloro-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl) ester | 60395-52-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: carbonic acid bis-(2-{4-[3-(2-chloro-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl) ester
• 英文别名: Bis[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl] carbonate
• CAS: 60395-52-0
• 化学式: C₄₃H₅₀Cl₂N₆O₃S₂
• 分子量: 833.946
• InChiKey: WIGZZXQZTANRMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  56
• 可旋转键数：
  16
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  106
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  1-chlorocarbonyloxy-2-{4-[3-(2-chloro-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethane; monohydrochloride 、 奋乃静 生成 carbonic acid bis-(2-{4-[3-(2-chloro-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl) ester
  参考文献：
  名称：

  Synthesis of carbonates of 2-substituted 4-[3-(phenothiazinyl-10)-propyl]piperazin-1-ethanol

  摘要：

  DOI：

  10.1007/bf00757830

文献信息

• SPASSKAYA I. F.; LAPIN I. P., XIM. -FARMATSEVT. ZH. <KNFZ-AN>, 1976, 10, HO 4, 24-27
  作者：SPASSKAYA I. F.、 LAPIN I. P.

  DOI：——

  日期：——
• METHODS AND COMPOSITIONS FOR REVERSING P-GLYCOPROTEIN MEDICATED DRUG RESISTANCE
  申请人：Chmielewski Jean A.

  公开号：US20100068786A1

  公开（公告）日：2010-03-18

  A method for inhibiting therapeutic drug resistance within a cell over-expressing a membrane protein is provided. The method comprises synthesizing a dimeric prodrug inhibitor of a monomeric therapeutic agent; administering the dimeric prodrug inhibitor to the membrane protein together with the monomeric therapeutic agent; and occupying at least one substrate binding site of the membrane protein with the synthesized dimeric prodrug to allow the monomeric therapeutic agent to accumulate within the cell. The dimeric prodrug inhibitor contains a crosslinking agent that is adapted to breakdown under reducing conditions within the cytosol of the cell to cause the dimeric prodrug to revert back to a form equivalent to the monomeric therapeutic agent.
• Synthesis of carbonates of 2-substituted 4-[3-(phenothiazinyl-10)-propyl]piperazin-1-ethanol
  作者：I. F. Spasskaya、I. P. Lapin

  DOI：10.1007/bf00757830

  日期：1976.4