cholesteryloxycarbonylmethyl-trimethyl-ammonium; chloride | 4834-38-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cholesteryloxycarbonylmethyl-trimethyl-ammonium; chloride
• 英文别名: Trimethylammonio-essigsaeure-cholesterylester; Chlorid；[2-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-2-oxoethyl]-trimethylazanium;chloride
• CAS: 4834-38-2
• 化学式: C₃₂H₅₆NO₂*Cl
• 分子量: 522.255
• InChiKey: PMOGURHOUKBKNR-LXZPIJOJSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.65
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  cholesterol 在 乙醚 作用下， 生成 cholesteryloxycarbonylmethyl-trimethyl-ammonium; chloride
  参考文献：
  名称：

  Dordoni et al., Ricerca Scientifica, 1951, vol. 21, p. 70,77

  摘要：

  DOI：

文献信息

• Betaine derivatives and process of making same
  申请人：CIBA PHARM PROD INC

  公开号：US02429171A1

  公开（公告）日：1947-10-14
• Quantification of sterol lipids in plants by quadrupole time-of-flight mass spectrometry
  作者：Vera Wewer、Isabel Dombrink、Katharina vom Dorp、Peter Dörmann

  DOI：10.1194/jlr.d013987

  日期：2011.5

  Glycerolipids, sphingolipids, and sterol lipids constitute the major lipid classes in plants. Sterol lipids are composed of free and conjugated sterols, i.e., sterol esters, sterol glycosides, and acylated sterol glycosides. Sterol lipids play crucial roles during adaption to abiotic stresses and plant-pathogen interactions. Presently, no comprehensive method for sterol lipid quantification in plants is available. We Q1 used nanospray ionization quadrupole-time-of-flight mass spectrometry (Q-TOF MS) to resolve and identify the molecular species of all four sterol lipid classes from Arabidopsis thaliana. Free sterols were derivatized with chlorobetainyl chloride. Sterol esters, sterol glycosides, and acylated sterol glycosides were ionized as ammonium adducts. Quantification of molecular species was achieved in the positive mode after fragmentation in the presence of internal standards. The amounts of sterol lipids quantified by Q-TOF MS/MS were validated by comparison with results obtained with TLC/GC. Quantification of sterol lipids from leaves and roots of phosphate-deprived A. thaliana plants revealed changes in the amounts and molecular species composition. The Q-TOF method is far more sensitive than GC or HPLC. Therefore, Q-TOF MS/MS provides a comprehensive strategy for sterol lipid quantification that can be adapted to other tandem mass spectrometers.-Wewer, V., I. Dombrink, K. vom Dorp, and P. Dormann. Quantification of sterol lipids in plants by quadrupole time-of-flight mass spectrometry. J. Lipid Res. 2011. 52: 1039-1054.
• Emulsion
  申请人：HARRIS BENJAMIN R

  公开号：US01917250A1

  公开（公告）日：1933-07-11
• AMPHOTERIC LIPOSOMES COMPRISING NEUTRAL LIPIDS
  申请人：Panzner Steffen

  公开号：US20100330154A1

  公开（公告）日：2010-12-30

  An amphoteric liposome comprising neutral lipids wherein said neutral lipids are selected from the group comprising cholesterol or mixtures of cholesterol and at least one neutral or zwitterionic lipid and wherein K (neutral) of said mixtures is 0.3 or less. Said amphoteric liposome may encapsulate an active agent, such as nucleic acid therapeutics. Also disclosed are pharmaceutical compositions comprising said amphoteric liposomes as a carrier for the delivery or targeted delivery of active agents or ingredients.
• Dordoni et al., Ricerca Scientifica, 1951, vol. 21, p. 70,77
  作者：Dordoni et al.

  DOI：——

  日期：——