1-cyclohexylindene | 94445-40-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 1-cyclohexylindene
• 英文别名: 1-cyclohexyl-1H-indene
• CAS: 94445-40-6
• 化学式: C₁₅H₁₈
• 分子量: 198.308
• InChiKey: VWZGLCZEBUOTGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  4-乙酰氨-2,2,6,6-四甲基哌啶-1-氧 、 1-cyclohexylindene 、 苯硼酸 在 potassium fluoride 、 palladium diacetate 、 丙酸 作用下， 反应 1.0h， 以70%的产率得到N-[1-(3-cyclohexyl-2-phenyl-indan-1-yloxy)-2,2,6,6-tetramethyl-piperidin-4-yl]-acetamide
  参考文献：
  名称：

  1,2,3-三取代茚满的高非对映选择性钯催化芳基硼酸和氮氧化物的氧化羰基化

  摘要：

  通过使用各种TEMPO衍生物作为外部氧化剂和Pd（OAc）2作为易制得的3，取代的茚满A与市售的芳基硼酸的反应，在生物学上有趣的1,2,3-三取代的茚满B的合成中获得出色的立体选择性。催化剂。的抗，抗异构体形成和温和的条件下发生立体特异性反应。

  DOI：

  10.1002/anie.201002214
• 作为产物：
  描述：

  碘环己烷 、 茚 在 正丁基锂 、 水 、 氯化铵 作用下， 以 乙醚 、 正己烷 为溶剂， 以39%的产率得到1-cyclohexylindene
  参考文献：
  名称：

  1,2,3-三取代茚满的高非对映选择性钯催化芳基硼酸和氮氧化物的氧化羰基化

  摘要：

  通过使用各种TEMPO衍生物作为外部氧化剂和Pd（OAc）2作为易制得的3，取代的茚满A与市售的芳基硼酸的反应，在生物学上有趣的1,2,3-三取代的茚满B的合成中获得出色的立体选择性。催化剂。的抗，抗异构体形成和温和的条件下发生立体特异性反应。

  DOI：

  10.1002/anie.201002214

文献信息

• Silver-catalyzed coupling reactions of alkyl halides with indenyllithiums
  作者：Hidenori Someya、Hideki Yorimitsu、Koichiro Oshima

  DOI：10.1016/j.tet.2010.06.030

  日期：2010.8

  Coupling reactions of tertiary and secondary alkyl halides with indenyllithiums proceeded effectively in the presence of a catalytic amount of silver bromide to provide tertiary- and secondary-alkyl-substituted indene derivatives in good yields.

  在催化量的溴化银存在下，叔烷基卤化物和仲烷基卤化物与茚基锂的偶联反应有效地进行，从而以高收率提供了叔烷基和仲烷基取代的茚衍生物。
• Photochemical Allylation of Alkanes Enabled by Nickel Catalysis
  作者：Youxiang Jin、Elvis Wang Hei Ng、Tao Fan、Hajime Hirao、Liu-Zhu Gong

  DOI：10.1021/acscatal.2c02345

  日期：2022.8.19

  We have developed an allylic alkylation of alkanes by dual photo-HAT/nickel catalysis. In this reaction, radical-type hydrogen-atom-transfer of the alkanes is enabled by decatungstate as a photocatalyst, whereas nickel serves to cleave the C–O bond in the substrates under mild reaction conditions. This co-catalyzed reaction provides a method for direct functionalization of alkanes. Density functional

  我们通过双光-HAT/镍催化开发了烷烃的烯丙基烷基化。在该反应中，烷烃的自由基型氢原子转移是通过十钨酸盐作为光催化剂实现的，而镍则用于在温和的反应条件下裂解基材中的 C-O 键。这种共催化反应提供了一种烷烃直接官能化的方法。密度泛函理论计算表明，还原消除是该反应的速率决定步骤。
• Ethylene-bridged C1-symmetric ansa-(3-R-indenyl)(fluorenyl) zirconocene complexes for propylene dimerization or polymerization: The effect of R group
  作者：Yan Wang、Wenzhong Huang、Haiyan Ma、Jiling Huang

  DOI：10.1016/j.poly.2014.03.019

  日期：2014.7

  A series of ethylene-bridged C-1-symmetric ansa-(3-R-indenyl)(fluorenyl) zirconocene complexes 3a-i (R = 2[2-(4-methylphenyl)propyl], 3a; R = 2-[2-(3,5-dimethylphenyl)propyl], 3h; R = 2-(2-benzylpropyl), 3c; R = 2-methylbenzyl, 3d; R = 2-(2-cyclohexylpropyl), 3e; R = 2-[2-(1-cyclohexenyl)propyl], 3f; R = 2-(2-n-butylpropyl), 3g; R = cyclohexyl, 3h; R = Pr-i, 3i) were synthesized by a salt metathesis method and characterized by NMR spectroscopy, elemental analysis (or HRMS) and X-ray diffraction (3e and 3h). Upon activation with methylaluminoxane, most of these zirconocene complexes exhibited sufficient catalytic activities up to 2.5 x 10(5) g C-6/(mol-Zr.h) and high selectivities up to 99% toward propylene dimerization, affording 2-methyl-1-pentene as the major isomer which was confirmed by gas chromatography. Remarkably, the selectivity and activity of complexes 3a-i were significantly influenced by the structural features of the substituent on the 3-position of indenyl ring: a pendant aryl or alkyl group linked by a quaternary carbon bridge provided the complex with high selectivities in the range of 89.9-99.0% for 2-methyl-1-pentene and low to moderate catalytic activities; the lack of a quaternary carbon bridge within the substituent would lead to mainly polypropylenes of low molecular weight. The steric hindrance around the active metal center induced by the pendant group might be responsible for the catalytic dimerization behavior, and the presumed mechanism was discussed. In addition, for complexes 3h and 3i, the selectivity for propylene dimerization could also be enhanced with the increase of reaction temperature. Noticeably, most of these ansa-zirconocene complexes exhibit excellent thermal stability at 100 degrees C, which is important with regard to industrial application. (C) 2014 Elsevier Ltd. All rights reserved.
• Padwa, Albert; Goldstein, Steven I., Canadian Journal of Chemistry, 1984, vol. 62, p. 2506 - 2514
  作者：Padwa, Albert、Goldstein, Steven I.

  DOI：——

  日期：——
• PADWA, A.;GOLDSTEIN, S. I., CAN. J. CHEM., 1984, 62, N 11, 2506-2514
  作者：PADWA, A.、GOLDSTEIN, S. I.

  DOI：——

  日期：——