3-trihydroxyethylammonium-n-propanesulfonate | 80297-71-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-trihydroxyethylammonium-n-propanesulfonate
• 英文别名: THEAPS；3-[Tris(2-hydroxyethyl)azaniumyl]propane-1-sulfonate
• CAS: 80297-71-8
• 化学式: C₉H₂₁NO₆S
• 分子量: 271.335
• InChiKey: MLDYOPICFFDOKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-trihydroxyethylammonium-n-propanesulfonate 在 盐酸 作用下， 以 水 为溶剂， 生成 N-(3-sulfopropyl)tri(2-hydroxyethyl)ammonium chloride
  参考文献：
  名称：

  Conversion of cellulose into levulinic acid under the catalysis of Brønsted acidic ionic liquid and erbium chloride in water

  摘要：

  DOI：

  10.1016/j.carres.2022.108675
• 作为产物：
  描述：

  1,3-丙烷磺内酯 、 三乙醇胺 以 1,2-二氯乙烷 为溶剂， 反应 2.5h， 以92%的产率得到3-trihydroxyethylammonium-n-propanesulfonate
  参考文献：
  名称：

  The Knoevenagel reaction in water catalyzed by zwitterionic liquids

  摘要：

  Three hydroxyl functionalized zwitterionic liquids (ZILs) were found to be novel recyclable catalysts for the Knoevenagel condensation between aldehydes or ketones and active methylene compounds in aqueous medium. Both aldehydes and ketones gave satisfactory results. The products could simply be separated from the catalysts/water, and the catalysts could be recycled six times without noticeably decreasing the catalytic activity.

  DOI：

  10.1007/s00706-008-0855-y

文献信息

• [EN] ORGANOSILANES FOR THE TREATMENT OF INFECTIONS<br/>[FR] ORGANOSILANES POUR LE TRAITEMENT D'INFECTIONS
  申请人：TOPIKOS PHARMACEUTICALS INC

  公开号：WO2020082026A1

  公开（公告）日：2020-04-23

  Organosilicon quaternary ammonium compounds, their formulations, including lyophilized solid formulations, and methods of use to treat infections in humans and animals. New organosilane quaternary ammonium compounds are provided that are useful in pharmaceutical topical formulations to treat a range of infections, including Gram positive, Gram negative and fungal infections, in a host in need thereof.

  有机硅季铵化合物，它们的配方，包括冻干固体配方，以及使用方法，用于治疗人类和动物感染。提供了新的有机硅季铵化合物，可用于制药局部配方，以治疗宿主中需要治疗的一系列感染，包括革兰氏阳性菌、革兰氏阴性菌和真菌感染。
• ORGANOSILANES FOR THE TREATMENT OF INFECTIONS
  申请人：Topikos Pharmaceuticals, Inc.

  公开号：US20210253607A1

  公开（公告）日：2021-08-19

  Organosilicon quaternary ammonium compounds, their formulations, including lyophilized solid formulations, and methods of use to treat infections in humans and animals.
• The Knoevenagel reaction in water catalyzed by zwitterionic liquids
  作者：Dong Fang、Zheng-hao Fei、Zu-liang Liu

  DOI：10.1007/s00706-008-0855-y

  日期：2008.7

  Three hydroxyl functionalized zwitterionic liquids (ZILs) were found to be novel recyclable catalysts for the Knoevenagel condensation between aldehydes or ketones and active methylene compounds in aqueous medium. Both aldehydes and ketones gave satisfactory results. The products could simply be separated from the catalysts/water, and the catalysts could be recycled six times without noticeably decreasing the catalytic activity.
• Conversion of cellulose into levulinic acid under the catalysis of Brønsted acidic ionic liquid and erbium chloride in water
  作者：Huifang Ren、Xiao-Yang Yue、Wen-Sheng Dong

  DOI：10.1016/j.carres.2022.108675

  日期：2022.12