bis(chloromethyl)phosphinic ethoxycarbonylamide | 242146-46-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: bis(chloromethyl)phosphinic ethoxycarbonylamide
• 英文别名: ethyl N-[bis(chloromethyl)phosphinoyl]carbamate；ethyl N-bis(chloromethyl)phosphinoylcarbamate；Carbamic acid, [bis(chloromethyl)phosphinyl]-, ethyl ester；ethyl N-[bis(chloromethyl)phosphoryl]carbamate
• CAS: 242146-46-9
• 化学式: C₅H₁₀Cl₂NO₃P
• 分子量: 234.019
• InChiKey: OKKCRIZIAPWECG-UHFFFAOYSA-N

物化性质

• 密度：
  1.374±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  bis(chloromethyl)phosphinic ethoxycarbonylamide 在 三乙胺 作用下， 以 苯 为溶剂， 反应 10.0h， 以77%的产率得到4-chloromethyl-2-ethoxy-4-oxo-1,3,4-oxazaphosphol-2-ine
  参考文献：
  名称：

  摘要：

  Bis(chloromethyl)phosphinic chloride reacts with urethane to give phosphorylated urethane, whereas with urea and acetamide the final reaction product is bis(chloromethyl)phosphinic anhydride.

  DOI：

  10.1023/a:1020798631871
• 作为产物：
  描述：

  ethyl N-trimethylsilylcarbamate 、 bis(chloromethyl)phosphinic chloride 反应 1.0h， 以43%的产率得到bis(chloromethyl)phosphinic ethoxycarbonylamide
  参考文献：
  名称：

  Synthesis of 1,3,4-oxazaphospholines based on phosphorylated carbamates

  摘要：

  Addition of alcohols to bis(chloromethyl)phosphinoyl isocyanate, as well as the reaction of bis(chloromethyl)phosphinoyl chloride with urethanes or their silylated derivatives, gave the corresponding phosphorylated carbamates which undergo cyclization into 1,3,4-oxazaphospholines under the action of Et(3)N.

  DOI：

  10.1007/bf02496276

文献信息

• Reaction of (chloromethyl)phosphonic(-phosphinic) iso(thio)cyanates with alcohols and (α-hydroxyalkyl)phosphonates
  作者：N. A. Khailova、R. Kh. Bagautdinova、M. A. Pudovik、R. Z. Musin、N. M. Azancheev、Sh. K. Latypov、T. A. Zyablikova、O. N. Kataeva、I. A. Litvinov、E. A. Evgen’eva、A. N. Pudovik

  DOI：10.1134/s107036320603008x

  日期：2006.3

  Alcohols and alpha-hydroxyphosphonates undergo the addition to (chloromethyl)phosphonic(-phosphinic) iso(thio)cyanates, yielding phosphorylated (thio)urethanes. The latter undergo cyclization to form, depending on their structure, saturated or unsaturated five-membered P,N,O,S-containin-heterocycles.
• Synthesis of 1,3,4-oxazaphospholines based on phosphorylated carbamates
  作者：M. A. Pudovik、G. M. Saakyan、V. K. Khairullin、N. A. Khailova、A. N. Pudovik

  DOI：10.1007/bf02496276

  日期：1999.4

  Addition of alcohols to bis(chloromethyl)phosphinoyl isocyanate, as well as the reaction of bis(chloromethyl)phosphinoyl chloride with urethanes or their silylated derivatives, gave the corresponding phosphorylated carbamates which undergo cyclization into 1,3,4-oxazaphospholines under the action of Et(3)N.
• ——
  作者：M. A. Pudovik、L. K. Kibardina、G. M. Saakyan、N. A. Khailova、A. A. Shaimardanova、N. E. Krepysheva、A. N. Pudovik

  DOI：10.1023/a:1020798631871

  日期：——

  Bis(chloromethyl)phosphinic chloride reacts with urethane to give phosphorylated urethane, whereas with urea and acetamide the final reaction product is bis(chloromethyl)phosphinic anhydride.