1,2,3,4-Tetrahydropyrido[2,3-d]pyrimidine | 857205-21-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 1,2,3,4-Tetrahydropyrido[2,3-d]pyrimidine
• CAS: 857205-21-1
• 化学式: C₇H₉N₃
• 分子量: 135.17
• InChiKey: VKXUCROJMDAHJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  37
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US20170158680A1

  公开（公告）日：2017-06-08

  The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.

  本发明提供了一种由公式（I）表示的杂环化合物，其立体异构体，或其药用可接受的盐，其药物组合物，以及它们用于制备预防或治疗中枢神经系统疾病的药物。
• Phenylpyri(mi)dinylazoles
  申请人：Sudau Alexander

  公开号：US20110183978A1

  公开（公告）日：2011-07-28

  Phenylpyri(mi)dinylazoles of the formula [I-a] and [I-b], wherein the symbols have the meanings stated in the description, and agrochemically active salts thereof and the use thereof for the control of undesired microorganisms in the protection of plants and materials and for the reduction of mycotoxins in plants and plant parts and methods for the production of compounds of the formula [I-a] and [I-b].

  式[I-a]和[I-b]的苯基吡啶基氮唑，其中符号的含义如说明中所述，以及其农业化学活性盐和在保护植物和材料中控制不良微生物以及减少植物和植物部分中真菌毒素的用途，以及制备式[I-a]和[I-b]化合物的方法。
• Process for the synthesis of cPLA2 inhibitors
  申请人：Dehnhardt M. Christoph

  公开号：US20050049296A1

  公开（公告）日：2005-03-03

  A process for making the compound of formula (I) wherein Ac represents acetate; X represents O or CH 2 ; Y represents C 1 -C 6 alkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF 3 , OCF 3 , OH, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkyl, NH 2 , N(C 1 -C 6 alkyl) 2 , NH(C 1 -C 6 alkyl), NC(O)-(C 1 -C 6 alkyl), and NO 2 . In his process, a compound of formula (II) is reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).

  一种制备化合物的方法，其化学式为(I)，其中Ac代表乙酸酯；X代表O或CH2；Y代表C1-C6烷基；Z选自H、卤素、CN、CHO、CF3、OCF3、OH、C1-C6烷基、C1-C6烷氧基、C1-C6硫代烷基、NH2、N(C1-C6烷基)2、NH(C1-C6烷基)、NC(O)-(C1-C6烷基)和NO2。在该方法中，化学式为(II)的化合物与肼反应形成一级烷基胺，然后一级烷基胺与乙酸酐反应，产生化合物的化学式为(I)。
• AKT protein kinase inhibitors
  申请人：Mitchell S. Ian

  公开号：US20050130954A1

  公开（公告）日：2005-06-16

  The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

  本发明提供化合物，包括已解决的对映体、二对映异构体、溶剂化物和药学上可接受的盐，其包括公式：A-L-CR，其中CR是一个环核心基团，L是一个连接基团，A如此处所定义。同时提供了使用本发明化合物作为AKT蛋白激酶抑制剂和用于治疗增殖性疾病如癌症的方法。
• AKT PROTEIN KINASE INHIBITORS
  申请人：Mitchell Ian S.

  公开号：US20100168123A1

  公开（公告）日：2010-07-01

  The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

  本发明提供了化合物，包括已分离的对映体、非对映异构体、溶剂化物和药学上可接受的盐，其包括式子：A-L-CR，其中CR是一个环状核心基团，L是一个连接基团，A如上所定义。本发明还提供了使用这些化合物作为AKT蛋白激酶抑制剂和治疗增殖性疾病，如癌症的方法。