2-[2-[2-(Tert-butylamino)ethoxy]ethoxy]ethanol | 99337-12-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[2-[2-(Tert-butylamino)ethoxy]ethoxy]ethanol
• CAS: 99337-12-9
• 化学式: C₁₀H₂₃NO₃
• 分子量: 205.298
• InChiKey: LLIRWOACVGPCOK-UHFFFAOYSA-N

物化性质

• 沸点：
  290.2±20.0 °C(Predicted)
• 密度：
  0.965±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  叔丁胺 生成 2-[2-[2-(Tert-butylamino)ethoxy]ethoxy]ethanol
  参考文献：
  名称：

  HO, W. S. WINSTON;STOGRYN, EUGENE L.;SARTORI, GUIDO

  摘要：

  DOI：

文献信息

• Improved Synthesis of Severely Sterically Hindered Amino-Ether Alcohols and Diaminopolyalkenyl Ethers Using a High Activity Powder Catalyst
  申请人：Elia Christine Nicole

  公开号：US20080058553A1

  公开（公告）日：2008-03-06

  The present invention relates to a process for preparing severely sterically hindered secondary amine ether alcohols and diamine polyalkenyl ethers by reacting a primary amino compound with a polyalkenylether glycol in the presence of a high activity nickel powder hydrogenation catalyst which is marked by high conversion of reactants and increased selectivity to desired final product.

  本发明涉及一种制备严重立体位阻的二次胺醚醇和二胺聚烯基醚的方法，通过在高活性镍粉加氢催化剂存在下，将一种初级氨基化合物与聚烯基醚乙二醇反应，以实现对反应物的高转化率和对期望最终产物的增加选择性。
• ANTIBODY DRUG CONJUGATES OF KINESIN SPINDEL PROTEIN (KSP) INHIBITORS WITH ANTIB7H3-ANTIBODIES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20200138970A1

  公开（公告）日：2020-05-07

  The present application relates to novel binder drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for the treatment and/or prophylaxis of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prophylaxis of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.

  本申请涉及新型结合剂药物偶联物（ADCs），这些ADCs的活性代谢物，制备这些ADCs的过程，将这些ADCs用于治疗和/或预防疾病，以及将这些ADCs用于制备治疗和/或预防疾病的药物，特别是高增殖和/或血管生成异常等疾病，例如癌症等。这种治疗可以作为单独治疗，也可以与其他药物或其他治疗措施结合使用。
• SEPARATION OF HYDROGEN SULFIDE FROM NATURAL GAS
  申请人：Kortunov Pavel

  公开号：US20150027056A1

  公开（公告）日：2015-01-29

  A process for increasing the selectivity of an alkanolamine absorption process for selectively removing hydrogen sulfide (H 2 S) from a gas mixture which also contains carbon dioxide (CO 2 ) and possibly other acidic gases such as COS, HCN, CS 2 and sulfur derivatives of C 1 to C 4 hydrocarbons, comprises contacting the gas mixture with a liquid absorbent which is a severely sterically hindered capped alkanolamine. The improvement in selectivity is achieved at the high(er) pressures, typically least about 10 bara at conditions nearing the H 2 S/CO 2 equilibrium at which CO 2 begins to displace absorbed hydrosulfide species from the absorbent solution.

  一种增加烷基醇胺吸收过程的选择性的方法，以有选择地从气体混合物中去除硫化氢（H2S），该混合物还包含二氧化碳（CO2）和可能包含其他酸性气体，如COS、HCN、CS2和C1至C4烃的硫衍生物，包括将气体混合物与一种液体吸收剂接触，该吸收剂是一种严重的立体位阻末端烷基醇胺。在高压下（通常至少约10 bara）的改进选择性是在接近H2S / CO2平衡的条件下实现的，此时CO2开始从吸收剂溶液中置换吸收的硫化氢物种。
• PROCESS FOR REMOVAL OF ACID GASES FROM A FLUID STREAM WITH A LIQUID ABSORBENT COMPRISING A PIPERAZINE RING
  申请人：BASF SE

  公开号：US20220152551A1

  公开（公告）日：2022-05-19

  A process for removal of acid gases from fluid stream, wherein the fluid stream is brought into contact with an absorbent to obtain a treated fluid stream and a laden absorbent, the absorbent comprising a diluent and a compound of the general formula (I) wherein R 1 is selected from C 1 -C 8 -alkyl and C 2 -C 8 -hydroxyalkyl; R 2 is selected from hydrogen and C 1 -C 8 -alkyl; R 3 is selected from hydrogen and C 1 -C 8 -alkyl; R 4 is selected from hydrogen and C 1 -C 8 -alkyl; R 5 is C 1 -C 8 -alkyl; with the proviso that at least one of the following conditions (i) and (ii) is met: (i) R 5 is C 3 -C 8 -alkyl bound to the nitrogen atom via a secondary or tertiary carbon atom; (ii) when R 4 is hydrogen, R 3 is C 1 -C 8 -alkyl; or when R 4 is C 1 -C 8 -alkyl, at least one of R 2 and R 3 is C 1 -C 8 -alkyl; and n is an integer from 0 to 6. Further provided is an absorbent for the absorption of acid gases from a fluid stream, comprising a diluent and a compound of the general formula (I) as defined above, as well as the use of a compound of the general formula (I) as defined above for removal of acid gases from a fluid stream. The absorbents are useful for the selective removal of hydrogen sulfide from fluid streams and have high acid gas loading capacity, high stability, and low volatility.

  一种从流体流中去除酸性气体的过程，其中将流体流与吸收剂接触以获得处理后的流体流和负载吸收剂，所述吸收剂包括稀释剂和通式（I）的化合物，其中R1选择自C1-C8烷基和C2-C8羟基烷基；R2选择自氢和C1-C8烷基；R3选择自氢和C1-C8烷基；R4选择自氢和C1-C8烷基；R5是C1-C8烷基；但至少满足以下条件之一（i）和（ii）之一：（i）R5是通过次级或三级碳原子与氮原子结合的C3-C8烷基；（ii）当R4为氢时，R3为C1-C8烷基；或当R4为C1-C8烷基时，至少有一个R2和R3是C1-C8烷基；n是0到6的整数。还提供了一种吸收剂，用于从流体流中吸收酸性气体，包括稀释剂和如上所述的通式（I）的化合物，以及使用如上所述的通式（I）的化合物从流体流中去除酸性气体。这些吸收剂对于选择性地从流体流中去除硫化氢非常有用，并具有高酸性气体负载能力，高稳定性和低挥发性。
• Acid gas enrichment method and system
  申请人：BASF SE

  公开号：US10875769B2

  公开（公告）日：2020-12-29

  A process for treating an H2S- and CO2-comprising fluid stream, in which a) the fluid stream is treated in a first absorber at a pressure of 10 to 150 bar with a first substream of a regenerated H2S-selective absorbent to obtain a treated fluid stream and an H2S-laden absorbent; b) the H2S-laden absorbent is heated by indirect heat exchange with regenerated H2S-selective absorbent; c) the heated H2S-laden absorbent is decompressed to a pressure of 1.2 to 10 bar in a low-pressure decompression vessel to obtain a first CO2-rich offgas and a partly regenerated absorbent; d) the partly regenerated absorbent is regenerated in a desorption column to obtain an H2S-rich offgas and regenerated absorbent; e) the H2S-rich offgas is fed to a Claus unit and the offgas from the Claus unit is fed to a hydrogenation unit to obtain hydrogenated Claus tail gas; f) the hydrogenated Claus tail gas and the first CO2-rich offgas are treated in a second absorber at a pressure of 1 to 4 bar with a second substream of the regenerated H2S-selective absorbent to obtain a second CO2-rich offgas and a second H2S-laden absorbent; and g) the second H2S-laden absorbent is guided into the first absorber. Also described is a plant suitable for performance of the process. The process is notable for a low energy requirement.

  一种处理含有 H2S 和 CO2 的流体流的工艺，其中 a) 在压力为 10 至 150 巴的第一吸收器中，用再生的 H2S 选择性吸收剂的第一子流处理流体流，得到处理过的流体流和含有 H2S 的吸收剂；b) 通过与再生的 H2S 选择性吸收剂进行间接热交换，加热含有 H2S 的吸收剂；c) 在低压减压容器中，将加热的含有 H2S 的吸收剂减压至压力为 1.2至10巴的低压减压容器中减压，得到富含CO2的第一种尾气和部分再生的吸收剂；d) 部分再生的吸收剂在解吸塔中再生，得到富含H2S的尾气和再生的吸收剂；e) 将富含H2S的尾气送入克劳斯装置，将克劳斯装置的尾气送入加氢装置，得到加氢克劳斯尾气；f) 将氢化克劳斯尾气和第一种富含 CO2 的尾气在压力为 1 至 4 巴的第二吸收器中用再生 H2S 选择性吸收剂的第二子流进行处理，以获得第二种富含 CO2 的尾气和第二种富含 H2S 的吸收剂；以及 g) 将第二种富含 H2S 的吸收剂导入第一吸收器。此外，还介绍了适用于该工艺的设备。该工艺的显著特点是能耗低。