N,N-dimethyl-10-undecen-1-amine | 34832-45-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dimethyl-10-undecen-1-amine
• 英文别名: N,N-dimethylundec-10-enamine；dimethyl-undec-10-enyl-amine；11-Dimethylamino-undec-1-en；Dimethyl-undec-10-enyl-amin；Dimethylamino undec-10-en；N,N-dimethylundec-10-en-1-amine
• CAS: 34832-45-6
• 化学式: C₁₃H₂₇N
• 分子量: 197.364
• InChiKey: KQPNDANLVGDRQS-UHFFFAOYSA-N

物化性质

• 沸点：
  244.5±9.0 °C(Predicted)
• 密度：
  0.804±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-dimethyl-10-undecen-1-amine 在 双氧水 作用下， 以 甲醇 、 乙醚 为溶剂， 生成 1-(N-methylacetamido)-10-undecene
  参考文献：
  名称：

  Ferles,M.; Jankovsky,M., Collection of Czechoslovak Chemical Communications, 1971, vol. 36, p. 4103 - 4106

  摘要：

  DOI：
• 作为产物：
  描述：

  10-十一碳烯基氯酸 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 N,N-dimethyl-10-undecen-1-amine
  参考文献：
  名称：

  Mukherjee,P.; Pathak,B., Journal of the Indian Chemical Society, 1973, vol. 50, p. 290 - 292

  摘要：

  DOI：

文献信息

• Catalytic Hydrogenation for Producing Amines from Carboxylic Acid Amides, Carboxylic Acid Diamides, Di-, Tri-, or Polypeptides, or Peptide Amides
  申请人：Evonik Degussa GmbH

  公开号：US20160272571A1

  公开（公告）日：2016-09-22

  The present invention relates to a process for the preparation of amines, comprising the following steps: a. reaction of a (i) carboxylic acid amide of the general formula (I), or (ii) carboxylic acid diamide of the general formula (II), or (iii) di-, tri- or polypeptide, or (iv) peptide amide with carboxy-terminal amide function with an alkylating agent, b. addition of a hydrogenation catalyst to the reaction mixture in a molar ratio of from 1:10 to 1:100 000, based on carboxylic acid amide, carboxylic acid diamide, di-, tri- or polypeptide or peptide amide, c. reaction of the reaction mixture with hydrogen, where a hydrogen pressure of from 0.1 bar to 200 bar is established and where a temperature in a range of from 0° C. to 250° C. is established.

  本发明涉及一种氨基的制备方法，包括以下步骤：a. 将通式（I）的羧酸酰胺，或通式（II）的羧酸二酰胺，或二肽、三肽或多肽，或带有羧基末端酰胺功能的肽酰胺与烷基化剂发生反应，b. 在摩尔比为1:10至1:100,000的范围内向反应混合物中加入氢化催化剂，基于羧酸酰胺、羧酸二酰胺、二肽、三肽或多肽或肽酰胺，c. 将反应混合物与氢气反应，在此建立氢气压力为0.1巴至200巴，并在0°C至250°C的温度范围内进行反应。
• Reduction of Amides to Amines under Mild Conditions via Catalytic Hydrogenation of Amide Acetals and Imidates
  作者：Renat Kadyrov

  DOI：10.1002/adsc.201800855

  日期：2019.1.11

  A simple and general protocol was developed for selective conversion of amides into amines. Amides were converted into amide acetals and imido esters by O‐alkylation and then hydrogenated without isolation into amines under very mild reaction conditions over standard hydrogenation catalysts. Triethyloxonium tertafluoroborate, methyl trifluoromethanesulfonate, dimethyl sulfate and ethyl chloroformate

  开发了一种简单而通用的方案，用于将酰胺选择性转化为胺。酰胺通过O-烷基化反应转化为酰胺缩醛和亚氨基酯，然后在非常温和的反应条件下，通过标准氢化催化剂在不分离的情况下氢化成胺。验证了四氟硼酸三乙基氧鎓，三氟甲基磺酸甲酯，硫酸二甲酯和氯甲酸乙酯是烷基化剂。该方法的合成效用通过肽基团的选择性羰基还原得到证明。肽基的羰基还原进行化学选择性，而没有相邻手性中心的外消旋化。
• Reduction and Reductive Deuteration of Tertiary Amides Mediated by Sodium Dispersions with Distinct Proton Donor-Dependent Chemoselectivity
  作者：Bin Zhang、Hengzhao Li、Yuxuan Ding、Yuhao Yan、Jie An

  DOI：10.1021/acs.joc.8b00617

  日期：2018.6.1

  practical and scalable single electron transfer reduction mediated by sodium dispersions has been developed for the reduction and reductive deuteration of tertiary amides. The chemoselectivity of this method highly depends on the nature of the proton donor. The challenging reduction via C–N bond cleavage has been achieved using Na/EtOH, affording alcohol products, while the use of Na/NaOH/H2O leads to the

  已经开发了由钠分散体介导的实用且可扩展的单电子转移还原，用于还原和还原叔酰胺。该方法的化学选择性高度取决于质子供体的性质。通过使用Na / EtOH（可提供醇类产物）实现C-N键断裂的富挑战性还原，而使用Na / NaOH / H 2 O则可通过选择性的C-O裂解形成胺。具有高比表面积的钠分散体对于获得高收率和良好的化学选择性至关重要。这种新方法可以耐受多种叔酰胺。此外，Na / EtOD- d 1和Na / NaOH / D 2介导的相应还原氘O提供有用的具有优异氘含量的α，α-二氘代醇和α，α-二氘代胺。
• Chromatographic material and method for preparation thereof
  申请人：DIONEX CORPORATION

  公开号：US09340562B1

  公开（公告）日：2016-05-17

  A chromatographic material comprising a zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II: wherein R1, R2, R3 are independently selected from an oxygen atom that is configured to connect to a substrate atom in the substrate, an oxygen atom that is configured to connect to a silicon atom of an adjacent ligand, a hydroxyl group, a halogen atom, an alkoxy group, a dialkylamino group, an acyl group, an alkyl group, or an aryl group; L1, L2 and L3 are independently hydrophobic moieties; each containing 2 to 30 carbon atoms, wherein there are at least 10 carbon atoms in the combined chain lengths of L1, L2 and L3; X is an O atom, S atom, amide group or sulfonamide group; n is 0 or 1; R4, R5 are independently selected from a hydrogen atom or a hydrocarbon moiety containing 1 to 20 carbon atoms; and Rf is a negatively charged moiety comprising a sulfonic, carboxylic, or phosphonic functional group.

  一种包含一个偶极配体共价结合到基底的色谱材料，该配体优选具有公式II： 其中R1、R2、R3独立选择自连接到基底中的基底原子的氧原子、连接到相邻配体的硅原子的氧原子、羟基、卤素原子、烷氧基、二烷基氨基基团、酰基、烷基或芳基；L1、L2和L3是独立的疏水基团，每个含有2到30个碳原子，其中L1、L2和L3的链长度组合中至少有10个碳原子；X是O原子、S原子、酰胺基团或磺酰胺基团；n为0或1；R4、R5独立选择自氢原子或含有1到20个碳原子的碳氢基团；以及Rf是包含磺酸、羧酸或磷酸官能团的带负电荷的基团。
• Copper-Catalyzed Reaction of C₆₀ with Tertiary Amines for the Preparation of Spiro-Linked Methanofullerenes and Fullerenoalkanals
  作者：Yong-Jian Liu、Jie Ge、Chun-Bao Miao、Hai-Tao Yang

  DOI：10.1021/acs.joc.9b00335

  日期：2019.5.17

  CuI-catalyzed reaction of C60 with tertiary amines by using air as the sole oxidant has been developed. Spiro-linked methanofullerenes bearing cyclic amides and fullerenoalkanals can be obtained selectively using the cyclic and acyclic amines as starting materials, respectively. The reactions show a wide functional group tolerance. In addition, four ([6,6]-phenyl-C61-butyric acid methyl ester) analogues

  通过使用空气作为唯一的氧化剂，已开发出CuI催化的C 60与叔胺的反应。分别使用环状和非环状胺作为起始原料，可以选择性地获得带有环状酰胺和富勒烯烷醛的螺旋连接的甲基富勒烯。反应显示出宽泛的官能团耐受性。另外，通过开发的方法可以容易地制备四个（[6,6]-苯基-C 61-丁酸甲酯）类似物。