(6-chloro-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetic acid | 77616-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (6-chloro-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetic acid
• 英文别名: 6-chloro-1,3-dioxo-1H-benzo[de]isoquinoline-2(3H)-acetic acid；6-chloro-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid；2-(6-chloro-1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid
• CAS: 77616-95-6
• 化学式: C₁₄H₈ClNO₄
• 分子量: 289.675
• InChiKey: JYIXOTNLDNRUMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (6-chloro-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetic acid 、 硫代水杨酸 在 potassium carbonate 作用下， 以 N-甲基乙酰胺 、 水 为溶剂， 生成 1,3-Dioxo-6-[(2-carboxyphenyl)thio]-1H-benz[de]isoquinoline-2(3H)-acetic acid
  参考文献：
  名称：

  1H-Benz[de]isoquinoline-2(3H)-acetic acid derivatives

  摘要：

  本文披露了1,3-二氧杂-1H-苯并[de]异喹啉-2(3H)-乙酸的6-取代衍生物。这些衍生物能抑制晶状体醛糖还原酶。

  公开号：

  US04254109A1
• 作为产物：
  描述：

  4-氯-1,8-萘二甲酸酐 、 聚甘氨酸 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 1.0h， 生成 (6-chloro-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-acetic acid
  参考文献：
  名称：

  多金属氧酸盐对淀粉样蛋白的定点化学修饰以抑制蛋白质错误折叠和聚集

  摘要：

  已经合成了一种噻唑烷硫酮 (TZ) 修饰的 Wells-Dawson 多金属氧酸盐 (POMD) 衍生物 (POMD-TZ)，它可以在 Lys16 位点选择性地共价修饰 β-淀粉样肽 (Aβ)。POMD-TZ对Aβ聚集的抑制作用远强于POMD，从而证明了化学翻译后修饰（PTM）方法对传统Aβ抑制剂修饰的优越性。

  DOI：

  10.1002/anie.202115336

文献信息

• Thioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid derivatives and
  申请人：Ayerst, McKenna & Harrison Inc.

  公开号：US04254108A1

  公开（公告）日：1981-03-03

  Herein disclosed are 1H-benz[de]isoquinoline-2(3H)-acetic acid derivatives. The derivatives are characterized by being derived from 1,3-dioxo-1H-benz[de]-isoquinoline-2H-acetic acid by replacing one of the oxygen atoms with sulfur and by optional substitution at position 6 with a phenylthio group. The derivatives inhibit lens aldose reductase in a diabetic subject.

  本文披露了1H-苯[de]异喹啉-2(3H)-乙酸衍生物。这些衍生物的特点是从1,3-二氧杂-1H-苯[de]-异喹啉-2H-乙酸中替换一个氧原子为硫，并在位置6处可选择地用苯基硫基进行取代。这些衍生物可以抑制糖尿病患者的晶状体醛固酮还原酶。
• 1H-Benz (de) isoquinoline -2 (3H) -acetic acid derivatives, processes for their preparation, pharmaceutical compositions containing same and their use
  申请人：AYERST, MCKENNA AND HARRISON INC.

  公开号：EP0028923A1

  公开（公告）日：1981-05-20

  The invention concerns new compounds of formula I in which X and Y are independently 0 or S, with the proviso both are not O or S, and Z is H or thiophenyl, a therapeutically acceptable organic or inorganic salt thereof or an ester thereof. The acids and salts are useful in the treatment of diabetes in mammals and the invention includes pharmaceutical compositions containing the active compounds. Processes for the preparation of the compounds are also described. The invention also includes the esters of the acids of formula 1, from which the acids may be prepared by hydrolysis.

  本发明涉及式 I 的新化合物。 其中 X 和 Y 独立地为 0 或 S，但两者均非 O 或 S，Z 为 H 或噻吩，是治疗上可接受的有机或无机盐或其酯。这些酸和盐可用于治疗哺乳动物的糖尿病，本发明包括含有这些活性化合物的药物组合物。本发明还描述了制备这些化合物的工艺。本发明还包括式 1 酸的酯，酸可通过水解制备。
• Thermoplastic polyester resin composition and molded articles produced therefrom
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0335595A2

  公开（公告）日：1989-10-04

  A thermoplastic polyester resin composition comprising a thermoplastic polyester and an effective amount for ultraviolet screening of at least one diimide compound selected from formulae (I) and (II): wherein: m and m each independently represents an integer of from 0 to 4; A and A each independently represents a halogen atom, -COOH or an ester thereof, -OH, -O-C(=O)CH3, -NH2, -CN, -N02, -S03H or a metal salt thereof, an unsubstituted or substituted alkoxyl group, an unsubstituted or substituted aliphatic group or an unsubstituted or substituted aromatic group, such that when m and/or m are/is from 2 to 4, A and A are the same or different from each other; X represents wherein Y represents SO2, -S-, C=O, -O-, -CH2-, -CH2CH2-, -CH=CH-, wherein any aromatic group in X is unsubstituted or substituted with a substituent as defined for A or A above; and Z represents wherein Y, which is the same or different from Y above, is as defined above, and any aromatic group in Z is unsubstituted or substituted with a substituent as defined for A or A' above.

  一种热塑性聚酯树脂组合物，包含一种热塑性聚酯和至少一种有效量的选自式 (I) 和 (II) 的二亚胺化合物的紫外线筛选剂： 其中 m 和 m 各自独立地代表 0 至 4 的整数； A和A各自独立地代表卤素原子、-COOH或其酯、-OH、-O-C(＝O)CH3、-NH2、-CN、-N02、-S03H或其金属盐、未取代或取代的烷氧基、未取代或取代的脂肪族基团或未取代或取代的芳香族基团，这样，当m和/或m为2至4时，A和A彼此相同或不同； X 代表 其中 Y 代表 SO2、-S-、C=O、-O-、-CH2-、- -、-CH=CH-、 其中 X 中的任何芳香基团未被取代或被上文 A 或 A 所定义的取代基所取代；以及 Z 代表 其中 Y（与上述 Y 相同或不同）如上定义，Z 中的任何芳香基团未被取代或被上述 A 或 A' 所定义的取代基取代。
• HYDROGEN PEROXIDE SENSORS BASED UPON PHOTO-INDUCED ELECTRON TRANSFER
  申请人：He Huarui

  公开号：US20120183984A1

  公开（公告）日：2012-07-19

  The invention provides compounds of formula I F-L-Q (I) where F comprises a fluorophore capable of absorbing energy at an excitation wavelength and, in the absence of a quencher, emitting energy at an emission wavelength, which is different than the excitation wavelength; Q comprises a quencher; L comprises a linker moiety having two ends, one end being covalently bound to F and the other end being covalently bound to Q. The compounds are capable of undergoing a reversible reaction (1), provided below: (1) where Q + is an oxidized form of Q representing the absence of a quencher, Ox comprises an oxidizing agent, which is capable of oxidizing Q to its oxidized form Q, and Red comprises a reducing agent, which is capable of converting Q back to its reduced form Q. The compounds can undergo photo-induced electron transfer when irradiated with energy and when Q exists in its oxidized form, Q + . The invention also provides methods of detecting and determining the presence of analytes and/or hydrogen peroxide in a sample, as well as a substrate that comprises the compound of formula I.
• US4254108A
  申请人：——

  公开号：US4254108A

  公开（公告）日：1981-03-03