4-Chloro Desloratadine | 133330-63-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并环庚烷吡啶
• 英文名称: 4-Chloro Desloratadine
• 英文别名: 7,13-dichloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaene
• CAS: 133330-63-9
• 化学式: C₁₉H₁₈Cl₂N₂
• 分子量: 345.3
• InChiKey: CCXNJIKOLAJTLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Tricylic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
  申请人：SCHERING CORPORATION

  公开号：EP1123931A1

  公开（公告）日：2001-08-16

  A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of formulae (5.0, 5.1, 5.2, 5.3, 5.3A and 5.3B) are disclosed. Also disclosed are process for making the 3-substituted compound of formulae (5.0, 5.1, 5.2 and 5.3). Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of formulae (5.0, 5.1, 5.2 and 5.3).

  本发明公开了一种抑制 Ras 功能从而抑制细胞异常生长的方法。该方法包括向生物系统施用式（1.0）化合物。特别是，该方法可抑制哺乳动物如人体内细胞的异常生长。本发明公开了式(5.0、5.1、5.2、5.3、5.3A 和 5.3B)的新型化合物。还公开了式 (5.0、5.1、5.2 和 5.3) 的 3-取代基化合物的制造工艺。还公开了作为式（5.0、5.1、5.2 和 5.3）3-取代化合物制造工艺中间体的新型化合物。
• EP0396083A1
  申请人：——

  公开号：EP0396083A1

  公开（公告）日：1990-11-07
• Heterocyclic N-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use
  申请人：SCHERING CORPORATION

  公开号：EP0396083B1

  公开（公告）日：1994-11-30
• Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylene and piperazine compounds as PAF antagonists and compositions thereof.
  申请人：SCHERING CORPORATION

  公开号：EP0535152B1

  公开（公告）日：1995-08-09
• TRICYCLIC CARBAMATE COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES
  申请人：SCHERING CORPORATION

  公开号：EP0723538B1

  公开（公告）日：2001-12-12