[4-[(2-Chloro-4-fluorophenyl)methyl]-1-piperazinyl](2,3-dihydro-1,4-benzodioxin-2-yl)methanone | 1060811-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: [4-[(2-Chloro-4-fluorophenyl)methyl]-1-piperazinyl](2,3-dihydro-1,4-benzodioxin-2-yl)methanone
• 英文别名: [4-[(2-chloro-4-fluorophenyl)methyl]piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
• CAS: 1060811-67-7
• 化学式: C₂₀H₂₀ClFN₂O₃
• 分子量: 390.8
• InChiKey: LGPYTYBIMHTGDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NOVEL BENZODIOXANE AND BENZOXAZINE DERIVATIVES USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS
  申请人：KHAMRAI Uttam

  公开号：US20100152160A1

  公开（公告）日：2010-06-17

  The present invention relates to benzodioxane and benzoxazine derivatives that act as ligands for CC chemokine receptors, such as CCR1. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

  本发明涉及作为CC化学趋化因子受体（如CCR1）配体的苯二氧杂环己烷和苯并噁嗪衍生物。该发明还涉及制备这些化合物的方法、含有这些化合物的组合物，以及使用这些化合物进行治疗的方法。
• [EN] NOVEL BENZODIOXANE AND BENZOXAZINE DERIVATIVES USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS<br/>[FR] NOUVEAUX DÉRIVÉS DE BENZODIOXANE ET BENZOXAZINE UTILES EN TANT QUE LIGANDS POUR LES RÉCEPTEURS DE CHIMIOKINE CC
  申请人：FOREST LAB HOLDINGS LTD

  公开号：WO2010068881A1

  公开（公告）日：2010-06-17

  The present invention relates to benzodioxane and benzoxazine derivatives that act as ligands for CC chemokine receptors, such as CCRl. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.