2-neopentylisoindoline-1,3-dione | 61020-63-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-neopentylisoindoline-1,3-dione
• 英文别名: N-(2,2-dimethyl-propyl)-phthalimide；N-Neopentyl-phthalimid；N-Neopentylphthalimid；2-(2,2-Dimethylpropyl)isoindole-1,3-dione
• CAS: 61020-63-1
• 化学式: C₁₃H₁₅NO₂
• 分子量: 217.268
• InChiKey: SYAQHEMJDDRWHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  邻苯二甲酰氯 在 三乙胺 作用下， 以 苯 为溶剂， 反应 0.3h， 生成 2-neopentylisoindoline-1,3-dione
  参考文献：
  名称：

  Ganin, E. V.; Anikin, V. F.; Rozynov, B. V., Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, # 1, p. 142 - 145

  摘要：

  DOI：

文献信息

• Carbonylative Synthesis of Phthalimides and Benzoxazinones by Using Phenyl Formate as a Carbon Monoxide Source
  作者：Sujit P. Chavan、Bhalchandra M. Bhanage

  DOI：10.1002/ejoc.201500109

  日期：2015.4

  efficient palladium-catalyzed carbonylative cyclization of N-substituted 2-iodobenzamides and 2-iodoanilides was investigated for the synthesis of phthalimides and benzoxazinones, respectively, by using phenyl formate as a CO source. The present catalytic protocol circumvents the use of an expensive phosphine ligand as well as solvent in the case of the phthalimide synthesis. Moreover, mild reaction conditions

  通过使用甲酸苯酯作为 CO 源，研究了一种简单有效的钯催化的 N-取代 2-碘苯甲酰胺和 2-碘苯胺的羰基化环化反应，分别用于合成邻苯二甲酰亚胺和苯并嗪酮。本催化协议在邻苯二甲酰亚胺合成的情况下避免使用昂贵的膦配体以及溶剂。此外，温和的反应条件和对各种官能团的耐受性增强了该方法的普遍适用性。
• A Biomass-Derived Non-Noble Cobalt Catalyst for Selective Hydrodehalogenation of Alkyl and (Hetero)Aryl Halides
  作者：Basudev Sahoo、Annette-Enrica Surkus、Marga-Martina Pohl、Jörg Radnik、Matthias Schneider、Stephan Bachmann、Michelangelo Scalone、Kathrin Junge、Matthias Beller

  DOI：10.1002/anie.201702478

  日期：2017.9.4

  straightforward approach for detoxifications of harmful anthropogenic organohalide-based pollutants, as well as removal of halide protecting groups used in multistep syntheses. A novel sustainable catalytic material was prepared from biowaste (chitosan) in combination with an earth-abundant cobalt salt. The heterogeneous catalyst was fully characterized by transmission electron microscope, X-ray diffraction,

  加氢脱卤是一种直接的方法，可以对有害的人为有机卤化物进行排毒，并去除多步合成中使用的卤化物保护基。一种新型的可持续催化材料是由生物废料（壳聚糖）与富含地球的钴盐结合制成的。通过透射电子显微镜，X射线衍射和X射线光电子能谱测量对多相催化剂进行了充分表征，并将其成功应用于烷基卤和（杂）芳基卤化物的加氢脱卤，适用范围广（> 40个实例），并且具有出色的化学选择性氢作为还原剂。这种方法的普遍用途通过不可降解农药和阻燃剂的成功排毒得到证明。而且，
• [EN] DIHYDROFURAN DERIVATIVES AS INSECTICIDAL COMPOUNDS<br/>[FR] DÉRIVÉS DE DIHYDROFURANE EN TANT QUE COMPOSÉS INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013026726A1

  公开（公告）日：2013-02-28

  The present invention provides compounds of formula I wherein Q is Q1 or Q2; A1, A2, A3 and A4 are independently of each other C-H, C-R7, or nitrogen; R1 is C1-C8haloalkyl; R2 is aryl or aryl substituted by one to five R11, or heteroaryl or heteroaryl substituted by one to five R11; and R3, R4, R5, R6 and R7 are as defined in the claims. The invention also provides methods of controlling insects, acarines, nematodes or molluscs which methods comprise applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I).

  本发明提供了式I的化合物，其中Q是Q1或Q2；A1、A2、A3和A4分别独立地为C-H、C-R7或氮；R1为C1-C8卤代烷基；R2为芳基或被1至5个R11取代的芳基，或者为杂环芳基或被1至5个R11取代的杂环芳基；以及R3、R4、R5、R6和R7如权利要求中所定义的。该发明还提供了控制昆虫、螨虫、线虫或软体动物的方法，该方法包括向害虫、害虫的生境或易受害虫侵害的植物施加式(I)的化合物的杀虫、杀螨、杀线虫或杀软体动物的有效量。
• Dioxanes and uses thereof
  申请人：——

  公开号：US20040072849A1

  公开（公告）日：2004-04-15

  In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): 1 and pharmaceutically acceptable derivatives thereof, wherein R 1 , R 2 , R 3 , n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.

  鉴于需要开发新型治疗剂和有效的合成方法，本发明提供了一般式(I)的新化合物： 1 及其药学上可接受的衍生物，其中R 1 ，R 2 ，R 3 ，n，X和Y如本文所定义。本发明还提供了包含一种式(I)化合物和药学上可接受的载体的药物组合物。本发明还提供了能够抑制组蛋白去乙酰化酶活性的化合物以及治疗由组蛋白去乙酰化酶活性调节的疾病的方法（例如，癌症和原虫感染），包括向需要的受体施用一种式(I)化合物的治疗有效量。本发明还提供了调节Ure2p下游葡萄糖敏感基因子集的方法。本发明还提供了制备本发明化合物的方法。
• Photoinduced, Copper-Catalyzed Decarboxylative C–N Coupling to Generate Protected Amines: An Alternative to the Curtius Rearrangement
  作者：Wei Zhao、Ryan P. Wurz、Jonas C. Peters、Gregory C. Fu

  DOI：10.1021/jacs.7b07546

  日期：2017.9.6

  classic, powerful method for converting carboxylic acids into protected amines, but its widespread use is impeded by safety issues (the need to handle azides). We have developed an alternative to the Curtius rearrangement that employs a copper catalyst in combination with blue-LED irradiation to achieve the decarboxylative coupling of aliphatic carboxylic acid derivatives (specifically, readily available

  Curtius 重排是将羧酸转化为受保护胺的经典、强大的方法，但其广泛使用受到安全问题（需要处理叠氮化物）的阻碍。我们开发了 Curtius 重排的替代方案，它采用铜催化剂与蓝光 LED 照射相结合，实现脂肪族羧酸衍生物（特别是容易获得的 N-羟基邻苯二甲酰亚胺酯）的脱羧偶联，在温和条件下提供受保护的胺。这种 CN 键形成过程与多种官能团兼容，包括醇、醛、环氧化物、吲哚、硝基烷烃和硫化物。控制反应和机理研究与铜物种参与光化学和关键键形成步骤的假设一致，