6,7,8-trimethoxy-2-(5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-quinazolin-4-ylamine | 52759-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6,7,8-trimethoxy-2-(5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-quinazolin-4-ylamine
• 英文别名: 4-Amino-6,7,8-trimethoxy-2-(5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)quinazoline；6,7,8-trimethoxy-2-(5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)quinazolin-4-amine
• CAS: 52759-36-1
• 化学式: C₂₃H₂₈N₄O₆
• 分子量: 456.499
• InChiKey: GHTOWCIDTWUCDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline (nortehuanine) 、 2-氯-6,7,8-三甲氧基-4-喹唑啉胺 以In this particular instance, the final product was obtained as the free base compound, m.p. 193°-195°C.的产率得到6,7,8-trimethoxy-2-(5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-quinazolin-4-ylamine
  参考文献：
  名称：

  2 (OR 4) Amino 4 (or 2) N-hetero quinazolines

  摘要：

  一系列新型的2-氨基和4-氨基喹唑啉衍生物已经制备出来，包括它们的酸加成盐。这些衍生物都在分子的4-或2-位置拥有一个含氮苯并杂环环基，该环基通过氮原子连接到上述喹唑啉核。这些化合物作为高效的降压剂在治疗中非常有用。详细描述了它们的制备方法，包括导致所需新型中间体的各种合成途径。

  公开号：

  US03960861A1

文献信息

• 2 (OR 4) Amino 4 (or 2) N-hetero quinazolines
  申请人：Pfizer Inc.

  公开号：US03960861A1

  公开（公告）日：1976-06-01

  A series of novel 2-amino and 4-aminoquinazoline derivatives have been prepared, including their acid addition salts. These derivatives all possess a single nitrogen-containing benzo-fused heterocyclic ring moiety at either the 4- or 2- positions of the molecule, respectively, with the ring moiety being attached through the nitrogen atom to the aforesaid quinazoline nucleus. Such compounds are useful in therapy as highly potent antihypertensive agents. Methods for their preparation are described in detail, including various synthetic routes leading to the required novel intermediates.

  已制备一系列新颖的2-氨基和4-氨基喹唑啉衍生物，包括它们的酸加成盐。这些衍生物都在分子的4-或2-位置具有一个含氮苯融合杂环环基，该环基通过氮原子连接到上述喹唑啉核。这些化合物在治疗中具有高效的降压剂作用。详细描述了它们的制备方法，包括通往所需新颖中间体的各种合成途径。
• Aminoquinazoline therapeutic agents
  申请人：Pfizer Inc.

  公开号：US04044136A1

  公开（公告）日：1977-08-23

  A series of novel 2-amino and 4-aminoquinazoline derivatives have been prepared, including their acid addition salts. These derivatives all possess a single nitrogen-containing benzo-fused heterocyclic ring moiety at either the 4- or 2-positions of the molecule, respectively, with the ring moiety being attached through the nitrogen atom to the aforesaid quinazoline nucleus. Such compounds are useful in therapy as highly potent antihypertensive agents. Methods for their preparation are described in detail, including various synthetic routes leading to the required novel intermediates.

  一系列新型的2-氨基和4-氨基喹唑啉衍生物已经制备出来，包括它们的酸加成盐。这些衍生物在分子的4-或2-位置上都具有单一的含氮苯并杂环环基，该环基通过氮原子与上述喹唑啉核结构连接。这些化合物作为高效的降压剂在治疗中有用。详细描述了它们的制备方法，包括导致所需新型中间体的各种合成途径。