2-ethyl-1,2,3,4-tetrahydro-2-naphthol | 102936-17-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-ethyl-1,2,3,4-tetrahydro-2-naphthol
• 英文别名: 2-ethyl-3,4-dihydro-1H-naphthalen-2-ol
• CAS: 102936-17-4
• 化学式: C₁₂H₁₆O
• 分子量: 176.258
• InChiKey: KTWPVGMXTSASRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙基氯化镁 、 β-四氢萘酮 在 cerium(III) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以76%的产率得到2-ethyl-1,2,3,4-tetrahydro-2-naphthol
  参考文献：
  名称：

  氯化铈促进的格氏试剂向酮的亲核加成是合成叔醇的有效方法

  摘要：

  在无水氯化铈（III）的存在下，格氏试剂与酮反应以高收率提供加成产物，即使底物仅与格氏试剂容易发生异常反应。

  DOI：

  10.1016/s0040-4039(00)94945-1

文献信息

• Reactions of carbonyl compounds with Grignard reagents in the presence of cerium chloride
  作者：Tsuneo Imamoto、Nobuyuki Takiyama、Kimikazu Nakamura、Toshihiko Hatajima、Yasuo Kamiya

  DOI：10.1021/ja00194a037

  日期：1989.6

  The addition of Grignard reagents to ketones is significantly enhanced by cerium chloride with remarkable suppression of side reactions, particularly enolization. Some esters, which are prone to side reactions, also react readily with Grignard reagents in the presence of cerium chloride to give normal reaction products in reasonable to high yields.

  氯化铈显着增强了格氏试剂向酮中的添加，显着抑制了副反应，尤其是烯醇化。一些易于发生副反应的酯在氯化铈存在下也很容易与格氏试剂反应，以合理到高产率得到正常反应产物。
• POSITIVE RESIST COMPOSITION AND PATTTERNING PROCESS
  申请人：Hatakeyama Jun

  公开号：US20130029269A1

  公开（公告）日：2013-01-31

  A positive resist composition comprising a polymer having carboxyl groups substituted with an acid labile group having formula (1) exhibits a high contrast of alkaline dissolution rate before and after exposure, a high resolution, a good pattern profile and minimal edge roughness. In formula (1), A is —(CR 2 2 ) m —, B is —(CR 5 2 ) n —, R 2 and R 5 are hydrogen or alkyl, m and n are 1 or 2, R 3 is alkyl, alkenyl, alkynyl or aryl, R 6 is alkyl, alkoxy, alkanoyl, alkoxycarbonyl, hydroxyl, nitro, aryl, halogen, or cyano, and p is 0 to 4.

  具有以下化学式（1）的酸敏聚合物，其羧基被酸敏基取代的正性光刻胶组合物，在曝光前后呈现高对比度的碱性溶解速率、高分辨率、良好的图案轮廓和最小的边缘粗糙度。在化学式（1）中，A为—（CR22）m—，B为—（CR52）n—，R2和R5为氢或烷基，m和n为1或2，R3为烷基、烯基、炔基或芳基，R6为烷基、烷氧基、烷酰基、烷氧羰基、羟基、硝基、芳基、卤素或氰基，p为0至4。
• IMAMOTO, TSUNEO;TAKIYAMA, NOBUYUKI;NAKAMURA, KIMIKAZU, TETRAHEDRON LETT., 1985, 26, N 39, 4763-4766
  作者：IMAMOTO, TSUNEO、TAKIYAMA, NOBUYUKI、NAKAMURA, KIMIKAZU

  DOI：——

  日期：——
• REVERSED BIARYL SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS
  申请人：McCormick Kevin D.

  公开号：US20130079271A1

  公开（公告）日：2013-03-28

  In its many embodiments, the present invention provides a novel class of biaryl spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.
• US8808966B2
  申请人：——

  公开号：US8808966B2

  公开（公告）日：2014-08-19