1,6-dimethylphenazine | 58718-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,6-dimethylphenazine
• CAS: 58718-43-7
• 化学式: C₁₄H₁₂N₂
• 分子量: 208.263
• InChiKey: XEWNMXMURNDKRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,6-dimethylphenazine 在 双氧水 、 乙酸酐 作用下， 生成 1,6-dimethyl-phenazine 5-oxide
  参考文献：
  名称：

  Kidani; Otomasu, Pharmaceutical Bulletin, 1956, vol. 4, p. 391,394

  摘要：

  DOI：
• 作为产物：
  描述：

  邻甲苯胺 在 盐酸 作用下， 生成 1,6-dimethylphenazine
  参考文献：
  名称：

  Malaviya; Dutt, 1934, vol. 4, p. 319,321

  摘要：

  DOI：

文献信息

• Low-temperature Photolysis of<i>ortho</i>-Substituted Azidobiphenyls. Formation of Phenazines from 2,2′-Diazidobiphenyls
  作者：Akira Yabe

  DOI：10.1246/bcsj.53.2933

  日期：1980.10

  in a rigid matrix. The phenazine formation results from the 1,1′-C–C bond fission of the biphenyl nucleus and suggests the aziridine intermediates. The low-temperature photolysis of 2-azido-2′-methylbiphenyl and 2-azido-2′,4′,6′-trimethylbiphenyl leads to the triplet-derived phenanthridine derivatives as major products.

  发现意外的吩嗪是通过 2,2'-二叠氮联苯在刚性基质中的低温光解形成的次要产物。吩嗪的形成源于联苯核的 1,1'-C-C 键裂变，并暗示了氮丙啶中间体。2-叠氮基-2'-甲基联苯和2-叠氮基-2',4',6'-三甲基联苯的低温光解导致三联体衍生的菲啶衍生物作为主要产物。
• Phenazine derivatives as antimicrobial agents
  申请人：University of Florida Research Foundation, Incorporated

  公开号：US11053205B2

  公开（公告）日：2021-07-06

  The present invention provides novel phenazine derivatives, such as compounds of Formula (I) (e.g., Formulae (II)-(XIX)), and pharmaceutically acceptable salts thereof. The compounds of the invention are expected to be antimicrobial agents and may act by a microbial warfare strategy (e.g., a reactive oxygen species (ROS)-based competition strategy). The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the compounds of the invention and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection or mycobacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium or mycobacterium), killing a microorganism (e.g., a bacterium or mycobacterium), inhibiting the formation and/or growth of a biofilm, reducing or clearing a biofilm, and/or disinfecting a surface.

  本发明提供了新型吩嗪衍生物，如式(I)化合物（如式(II)-(XIX)）及其药学上可接受的盐类。本发明的化合物有望成为抗菌剂，并可通过微生物战争策略（如基于活性氧（ROS）的竞争策略）发挥作用。本发明还提供了涉及本发明化合物的药物组合物、试剂盒、用途和方法，可用于预防或治疗受试者的微生物感染（如细菌感染或分枝杆菌感染），抑制微生物（如细菌或分枝杆菌）的生长和/或繁殖、细菌或分枝杆菌）的生长和/或繁殖，杀死微生物（如细菌或分枝杆菌），抑制生物膜的形成和/或生长，减少或清除生物膜，和/或消毒表面。
• YABE AKIRA, BULL. CHEM. SOC. JAP., 1980, 53, NO 10, 2933-2937
  作者：YABE AKIRA

  DOI：——

  日期：——
• [EN] PHENAZINE DERIVATIVES AS ANTIMICROBIAL AGENTS<br/>[FR] DÉRIVÉS DE PHÉNAZINE UTILISÉS COMME AGENTS ANTIMICROBIENS
  申请人：UNIV OF RESEARCH FOUNDATION INCORPORATED

  公开号：WO2018152436A1

  公开（公告）日：2018-08-23

  The present invention provides novel phenazine derivatives, such as compounds of Formula (I) (e.g., Formulae (II) - (XIX)), and pharmaceutically acceptable salts thereof. The compounds of the invention are expected to be antimicrobial agents and may act by a microbial warfare strategy (e.g., a reactive oxygen species (ROS)-based competition strategy). The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the compounds of the invention and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection or mycobacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium or mycobacterium), killing a microorganism (e.g., a bacterium or mycobacterium), inhibiting the formation and/or growth of a biofilm, reducing or clearing a biofilm, and/or disinfecting a surface.
• Kidani; Otomasu, Pharmaceutical Bulletin, 1956, vol. 4, p. 391,394
  作者：Kidani、Otomasu

  DOI：——

  日期：——

表征谱图