[amino-[4-[(E)-2-[4-[amino(azaniumylidene)methyl]-2-hydroxyphenyl]ethenyl]phenyl]methylidene]azanium;methanesulfonate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: [amino-[4-[(E)-2-[4-[amino(azaniumylidene)methyl]-2-hydroxyphenyl]ethenyl]phenyl]methylidene]azanium;methanesulfonate
• 化学式: C18H24N4O7S2
• 分子量: 472.5
• InChiKey: YGNSQKCULHSJDC-HFPMQDOPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.14
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  246
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• ErbB2 signaling and nerve regeneration
  申请人：THE HOSPITAL FOR SICK CHILDREN

  公开号：US11053321B2

  公开（公告）日：2021-07-06

  Use of an inhibitor of the ErbB2 receptor for treatment or repair of nerves and/or nerve tissues is provided. The inhibitor includes an antibody, in particular, a monoclonal antibody, for example, Herceptin. A medicament for treatment or repair of nerves and/or nerve tissues can be formulated which includes an inhibitor of the ErbB2 receptor. A pharmaceutical kit may include a medicament having an inhibitor of the ErbB2 receptor and dosing instructions for administrating the medicament for treatment or repair of nerves and/or nerve tissues. Also provided are uses of an inhibitor of the ErbB2 receptor for increasing axon regeneration, preventing neuron or glial cell death, and/or stimulating Schwann cell proliferation in a nerve stump.

  提供了一种用于治疗或修复神经和/或神经组织的 ErbB2 受体抑制剂。抑制剂包括抗体，特别是单克隆抗体，例如赫赛汀。可以配制一种用于治疗或修复神经和/或神经组织的药物，其中包括 ErbB2 受体抑制剂。药剂包可包括具有 ErbB2 受体抑制剂的药剂以及用于治疗或修复神经和/或神经组织的用药说明。还提供了 ErbB2 受体抑制剂在增加轴突再生、防止神经元或胶质细胞死亡和/或刺激神经残端许旺细胞增殖方面的用途。
• ERBB2 SIGNALING AND NERVE REGENERATION
  申请人：The Hospital For Sick Children

  公开号：EP3137110A1

  公开（公告）日：2017-03-08
• ErbB2 SIGNALING AND NERVE REGENERATION
  申请人：THE HOSPITAL FOR SICK CHILDREN

  公开号：US20220033517A1

  公开（公告）日：2022-02-03

  Use of an inhibitor of the ErbB2 receptor for treatment: or repair of nerves and/or nerve tissues is provided. The inhibitor includes art antibody, in particular, a monoclonal antibody, Or example, Herceptin. A medicament for treatment or repair of nerves and/or nerve tissues can be formulated which includes an inhibitor of the ErbB2 receptor. A pharmaceutical kit may include a medicament having an inhibitor of the ErbB2 receptor and dosing instructions for administrating the medicament for treatment or repair of nerves and/or nerve tissues. Also provided are uses of an inhibitor of the ErbB2 receptor for increasing axon regeneration, preventing neuron or glial cell death, and/or stimulating Schwann cell proliferation in a nerve stump.
• [EN] ERBB2 SIGNALING AND NERVE REGENERATION<br/>[FR] SIGNALISATION ERBB2 ET RÉGÉNÉRATION NERVEUSE
  申请人：HOSPITAL FOR SICK CHILDREN

  公开号：WO2015164984A1

  公开（公告）日：2015-11-05

  Use of an inhibitor of the ErbB2 receptor for treatment or repair of nerves and/or nerve tissues is provided. The inhibitor includes an antibody, in particular, a monoclonal antibody, for example, Herceptin. A medicament for treatment or repair of nerves and/or nerve tissues can be formulated which includes an inhibitor of the ErbB2 receptor. A pharmaceutical kit may include a medicament having an inhibitor of the ErbB2 receptor and dosing instructions for administrating the medicament for treatment or repair of nerves and/or nerve tissues. Also provided are uses of an inhibitor of the ErbB2 receptor for increasing axon regeneration, preventing neuron or glial cell death, and/or stimulating Schwann cell proliferation in a nerve stump.