(R,S)-4-cholesteryloxycarbonyl-2-oxetanone | 404567-90-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (R,S)-4-cholesteryloxycarbonyl-2-oxetanone
• 英文别名: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 4-oxooxetane-2-carboxylate
• CAS: 404567-90-4
• 化学式: C₃₁H₄₈O₄
• 分子量: 484.72
• InChiKey: AVHURMCZCKCGCU-YJYBKFEZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  胆固醇 、 4-氧代-2-氧杂环丁烷羧酸 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以45%的产率得到(R,S)-4-cholesteryloxycarbonyl-2-oxetanone
  参考文献：
  名称：

  Synthesis and Characterization of New Malolactonate Polymers and Copolymers for Biomedical Applications

  摘要：

  A new class of malolactonate polymers and copolymers were synthesized, starting from the corresponding lactones, and then Characterized. Different lateral groups were selected for these polyesters to achieve a wide range of materials characteristics and possible biological recognition. The monomers were prepared according to two established procedures, which gave rather good overall yields. The polymers were obtained by the anionic ring-opening polymerization of the corresponding four-member ring monomers in the presence of a quaternary ammonium salt: as the initiator. Final macromolecular and thermal characteristics were in agreement with the designed monomer structures. Molecular weights in the range 4-20 kDa were obtained, as a result of chain transfer reactions. The prepared polyesters displayed stability up to 200 degreesC, and, when tested in preliminary cell culture experiments, provided indications for future applications in the biomedical field.

  DOI：

  10.1021/ma0111257

文献信息

• Synthesis and Characterization of New Malolactonate Polymers and Copolymers for Biomedical Applications
  作者：Ranieri Bizzarri、Federica Chiellini、Roberto Solaro、Emo Chiellini、Sandrine Cammas-Marion、Philippe Guerin

  DOI：10.1021/ma0111257

  日期：2002.2.1

  A new class of malolactonate polymers and copolymers were synthesized, starting from the corresponding lactones, and then Characterized. Different lateral groups were selected for these polyesters to achieve a wide range of materials characteristics and possible biological recognition. The monomers were prepared according to two established procedures, which gave rather good overall yields. The polymers were obtained by the anionic ring-opening polymerization of the corresponding four-member ring monomers in the presence of a quaternary ammonium salt: as the initiator. Final macromolecular and thermal characteristics were in agreement with the designed monomer structures. Molecular weights in the range 4-20 kDa were obtained, as a result of chain transfer reactions. The prepared polyesters displayed stability up to 200 degreesC, and, when tested in preliminary cell culture experiments, provided indications for future applications in the biomedical field.