lithium cholesterol sulfate | 133058-04-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: lithium cholesterol sulfate
• 英文别名: cholesteryl-hydrogen sulfate; lithium cholesteryl sulfate；Cholesteryl-hydrogensulfat; Lithium-cholesterylsulfat；Cholesterol sulfate lithium salt；lithium;[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] sulfate
• CAS: 133058-04-5
• 化学式: C₂₇H₄₅O₄S*Li
• 分子量: 472.659
• InChiKey: UBKHBCQFYSQXIA-KPNWGBFJSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.88
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  硫酸 、 lithium cholesterol sulfate 生成 cholesterol
  参考文献：
  名称：

  Mandel; Neuberg, Biochemische Zeitschrift, 1915, vol. 71, p. 181

  摘要：

  DOI：
• 作为产物：
  描述：

  Pyridinium-cholesterylsulfat 、 alkaline earth salt of/the/ methylsulfuric acid 生成 lithium cholesterol sulfate
  参考文献：
  名称：

  Natelson; Sobel; Kramer, Journal of Biological Chemistry, 1934, vol. 105, p. 761,763

  摘要：

  DOI：

文献信息

• Lithium cholesterol compositions, including, but not limited to lithium cholesterol sulfate compositions, and methods of treatment for Alzheimer's disease and neurological disorders
  申请人：Tan Jun

  公开号：US10828312B2

  公开（公告）日：2020-11-10

  In one aspect, the disclosure relates to compositions of lithium cholesterol compositions, including but not limited to lithium cholesterol sulfate compositions which are useful as therapeutic agents. The disclosure also relates to methods of making lithium cholesterol compositions and pharmaceutical compositions comprising therapeutically effective amounts of the lithium cholesterol compositions. The present disclosure also includes methods of treating one or more clinical neurological conditions with the lithium cholesterol compositions, such as Alzheimer's disease, autism spectrum disorder, bipolar disorder, or other neuropsychiatric disorders.

  一方面，本公开涉及胆固醇锂组合物，包括但不限于可用作治疗剂的硫酸胆固醇锂组合物。本公开还涉及锂胆固醇组合物的制造方法和包含治疗有效量的锂胆固醇组合物的药物组合物。本公开还包括用锂胆固醇组合物治疗一种或多种临床神经疾病的方法，如阿尔茨海默病、自闭症谱系障碍、双相情感障碍或其他神经精神疾病。
• Natelson; Gottfried, Journal of the American Chemical Society, 1939, vol. 61, p. 971,972
  作者：Natelson、Gottfried

  DOI：——

  日期：——
• Studies in Steroid Metabolism. V. The Problem of Walden Inversion in the Reactions of Steroid Hydrogen Sulfates and Steroid Sulfites^1,2
  作者：Seymour Lieberman、Lucie B. Hariton、David K. Fukushima

  DOI：10.1021/ja01184a040

  日期：1948.4
• Gardner; Fox, Biochemical Journal, 1924, vol. 18, p. 1058,1063, 1064
  作者：Gardner、Fox

  DOI：——

  日期：——
• LITHIUM CHOLESTEROL COMPOSITIONS, INCLUDING, BUT NOT LIMITED TO LITHIUM CHOLESTEROL SULFATE COMPOSITIONS, AND METHODS OF TREATMENT FOR ALZHEIMER'S DISEASE AND NEUROLOGICAL DISORDERS
  申请人：Tan Jun

  公开号：US20200129527A1

  公开（公告）日：2020-04-30

  In one aspect, the disclosure relates to compositions of lithium cholesterol compositions, including but not limited to lithium cholesterol sulfate compositions which are useful as therapeutic agents. The disclosure also relates to methods of making lithium cholesterol compositions and pharmaceutical compositions comprising therapeutically effective amounts of the lithium cholesterol compositions. The present disclosure also includes methods of treating one or more clinical neurological conditions with the lithium cholesterol compositions, such as Alzheimer's disease, autism spectrum disorder, bipolar disorder, or other neuropsychiatric disorders.