6-Thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaene-2,8-dione | 126939-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环七噻吩
• 英文名称: 6-Thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaene-2,8-dione
• CAS: 126939-26-2
• 化学式: C₁₃H₈O₂S
• 分子量: 228.271
• InChiKey: QBXABUNTURPNNL-UHFFFAOYSA-N

物化性质

• 沸点：
  438.3±44.0 °C(Predicted)
• 密度：
  1.372±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  62.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-Thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaene-2,8-dione 在 盐酸 、 magnesium 作用下， 以 水 为溶剂， 反应 5.75h， 生成 酮替芬
  参考文献：
  名称：

  Polivka, Zdenek; Budesinsky, Milos; Holubek, Jiri, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 9, p. 2443 - 2469

  摘要：

  DOI：

文献信息

• POLIVKA, ZDENEK;BUDESINSKY, MILOS;HOLUBEK, JIRI;SCHNEIDER, BOHDAN;SEDIVY,+, COLLECT. CZECHOSL. CHEM. COMMUN., 54,(1989) N, C. 2443-2469
  作者：POLIVKA, ZDENEK、BUDESINSKY, MILOS、HOLUBEK, JIRI、SCHNEIDER, BOHDAN、SEDIVY,+

  DOI：——

  日期：——
• Heterocyclic Tetracyclic Tetrahydrofuran Derivatives As 5Ht2 Inhibitors In The Treatment Of Cns Disorders
  申请人：Cid-Nunez Maria Jose

  公开号：US20080108599A1

  公开（公告）日：2008-05-08

  This invention concerns novel substituted heterocyclic tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonin receptors, in particular 5-HT 2A and 5-HT 2C receptors, and towards dopamine receptors, in particular dopamine D 2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
• HETEROCYCLIC TETRACYCLIC TETRAHYDROFURAN DERIVATIVES
  申请人：Cid-Núñez José Maria

  公开号：US20110144094A1

  公开（公告）日：2011-06-16

  This invention concerns novel substituted heterocyclic tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonin receptors, in particular 5-HT 2A and 5-HT 2C receptors, and towards dopamine receptors, in particular dopamine D 2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
• US7915249B2
  申请人：——

  公开号：US7915249B2

  公开（公告）日：2011-03-29
• US8404729B2
  申请人：——

  公开号：US8404729B2

  公开（公告）日：2013-03-26