N-propyl-N-isopropylaniline | 180840-30-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-propyl-N-isopropylaniline
• 英文别名: N-isopropyl-N-propyl-aniline；N-Isopropyl-N-propyl-anilin；N-propan-2-yl-N-propylaniline
• CAS: 180840-30-6
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: RRMNZXFCMBXBNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  溴化氰 、 N-propyl-N-isopropylaniline 生成 isopropyl-phenyl-carbamonitrile
  参考文献：
  名称：

  RENAL FUNCTIONAL OUTCOME IN UNILATERAL HYDRONEPHROSIS IN NEWBORN PIGS

  摘要：

  Purpose: We followed the course of neonatally induced, partial unilateral ureteral obstruction in pigs and established whether early function or morphological evaluation of the hydronephrotic kidney is predictive of outcome.Materials and Methods: In 25 piglets unilateral partial ureteropelvic obstruction was induced 2 days after birth, while 11 underwent sham operation. Only obstructed kidneys with significant dilatation at 4 weeks were included for further study. Renal function was assessed on renography using (99m)technetium-diaminetriaminepentaacetic acid differential uptake. According to the plasma clearance of (99m)technetium-diaminetriaminepentaacetic acid the glomerular filtration rate was determined at ages 4, 12 and 24 weeks. Kidney morphology was studied in parallel by magnetic resonance imaging.Results: A total of 12 obstructed kidneys with grade 3 or 4 hydronephrosis fulfilled study inclusion criteria. Of 6 kidneys with a functional share of 40% or greater at age 4 weeks 2 deteriorated to less than 40% at 24 weeks, while 4 of 6 with st share of less than 40% at age 4 weeks improved to greater than 40% at 24 weeks. The single kidney glomerular filtration rate at 4 weeks did not correlate with that at 12 or 24 weeks but the rate at 12 weeks correlated with that at 24 weeks (r(2) = 0.8140, p <0.001). Neither relative volume of the obstructed kidney nor length of the contralateral nonobstructed kidney correlated with functional share of the obstructed kidney at any age.Conclusions: Early evaluation of kidney function or volume, or contralateral kidney length did not predict the outcome of neonatally induced unilateral hydronephrosis in pigs.

  DOI：

  10.1016/s0022-5347(05)67591-x
• 作为产物：
  描述：

  N-异丙基苯胺 、 1-碘代丙烷 生成 N-propyl-N-isopropylaniline
  参考文献：
  名称：

  RENAL FUNCTIONAL OUTCOME IN UNILATERAL HYDRONEPHROSIS IN NEWBORN PIGS

  摘要：

  Purpose: We followed the course of neonatally induced, partial unilateral ureteral obstruction in pigs and established whether early function or morphological evaluation of the hydronephrotic kidney is predictive of outcome.Materials and Methods: In 25 piglets unilateral partial ureteropelvic obstruction was induced 2 days after birth, while 11 underwent sham operation. Only obstructed kidneys with significant dilatation at 4 weeks were included for further study. Renal function was assessed on renography using (99m)technetium-diaminetriaminepentaacetic acid differential uptake. According to the plasma clearance of (99m)technetium-diaminetriaminepentaacetic acid the glomerular filtration rate was determined at ages 4, 12 and 24 weeks. Kidney morphology was studied in parallel by magnetic resonance imaging.Results: A total of 12 obstructed kidneys with grade 3 or 4 hydronephrosis fulfilled study inclusion criteria. Of 6 kidneys with a functional share of 40% or greater at age 4 weeks 2 deteriorated to less than 40% at 24 weeks, while 4 of 6 with st share of less than 40% at age 4 weeks improved to greater than 40% at 24 weeks. The single kidney glomerular filtration rate at 4 weeks did not correlate with that at 12 or 24 weeks but the rate at 12 weeks correlated with that at 24 weeks (r(2) = 0.8140, p <0.001). Neither relative volume of the obstructed kidney nor length of the contralateral nonobstructed kidney correlated with functional share of the obstructed kidney at any age.Conclusions: Early evaluation of kidney function or volume, or contralateral kidney length did not predict the outcome of neonatally induced unilateral hydronephrosis in pigs.

  DOI：

  10.1016/s0022-5347(05)67591-x

文献信息

• Iodine‐Catalyzed Oxidative Rearrangement of Amines to α‐Amino Acetals and α‐Amino Aldehydes
  作者：Min‐Jie Zhou、Shou‐Fei Zhu、Qi‐Lin Zhou

  DOI：10.1002/adsc.201801670

  日期：2019.3.15

  A protocol for iodine‐catalyzed oxidative rearrangement of tertiary and secondary amines has been developed. This metal‐free protocol provides an atom‐economical, efficient access to synthetically useful α‐amino acid derivatives from readily available acyclic and cyclic tertiary or secondary amines.

  已开发出碘催化的叔胺和仲胺氧化重排的方案。该无金属方案可从经济易得的无环和环状叔或仲胺原子经济有效地获得合成有用的α-氨基酸衍生物。
• Molecular Addition Compounds. 10. Borane Adducts with <i>N</i>,<i>N</i>-Dialkylanilines for Hydroboration
  作者：Herbert C. Brown、Marek Zaidlewicz、Pramod V. Dalvi

  DOI：10.1021/om980418u

  日期：1998.9.1

  Borane adducts with selected N,N-dialkylanilines have been prepared and examined as hydroborating agents. The adduct H3B:NPhPri2 is a solid, considered less desirable than liquid adducts as hydroborating agents. Fortunately, the adducts H3B:NPhBuiMe, H3B:NPhPriMe, H3B:NPhPriEt, and H3B:NPhPriPrn are liquids above 0 °C, hydroborating 1-octene in tetrahydrofuran in less than 1 h at room temperature.

  已经制备了具有选择的N，N-二烷基苯胺的硼烷加合物，并作为硼氢化剂进行了研究。加合物H 3 B：NPhPr i2是固体，被认为不如液体加合物作为氢硼酸酯化剂是合乎需要的。幸运的是，加合物H 3 B：NPhBu i我，H 3 B：NPhPr i我，H 3 B：NPhPr iEt和H 3 B：NPhPr i镨ñ是高于0°C的液体，在室温下少于1小时内在四氢呋喃中进行硼氢化1-辛烯。描述了通过硼烷-N，N-二异丙基苯胺加合物的热离解或通过2.00 M硼氢化钠在三甘醇二甲醚中的溶液与5.40 M的三氟化硼在三甘醇二甲醚溶液中的反应来定量生成气态乙硼烷的简便方法。
• US4115413A
  申请人：——

  公开号：US4115413A

  公开（公告）日：1978-09-19
• US5543569A
  申请人：——

  公开号：US5543569A

  公开（公告）日：1996-08-06
• US7667052B2
  申请人：——

  公开号：US7667052B2

  公开（公告）日：2010-02-23