2,4,4,5,5-pentamethyl-1,3,2-dioxaphosphole 2-oxide | 18789-38-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 2,4,4,5,5-pentamethyl-1,3,2-dioxaphosphole 2-oxide
• 英文别名: 2,4,4,5,5-Pentamethyl-1,3,2lambda5-dioxaphospholane 2-oxide；2,4,4,5,5-pentamethyl-1,3,2λ5-dioxaphospholane 2-oxide
• CAS: 18789-38-3
• 化学式: C₇H₁₅O₃P
• 分子量: 178.168
• InChiKey: ICBMCUUFFVPXSP-UHFFFAOYSA-N

物化性质

• 沸点：
  199.9±7.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲氧基-4,4,5,5-四甲基-[1,3,2]-二氧杂磷杂环戊烷 在 三氟甲磺酸 作用下， 反应 16.0h， 以92%的产率得到2,4,4,5,5-pentamethyl-1,3,2-dioxaphosphole 2-oxide
  参考文献：
  名称：

  水决定了产物：意外的布朗斯台德酸催化P（III）酯的PO-R裂解，选择性地产生P（O）-H和P（O）-R化合物

  摘要：

  发现水能够确定布朗斯台德酸催化的亚磷酸三烷基酯的C-O裂解反应的选择性：与水一起，该反应在室温下迅速发生，从而定量获得H-膦酸酯的收率。在不加水的情况下，该反应选择性地以高收率提供了烷基膦酸酯，为著名的Michaelis-Arbuzov反应提供了一种新型的无卤化物替代方案。该方法是通用的，因为它可以很容易地扩展到亚膦酸酯和次膦酸酯以及大规模的反应，而催化剂的负载却低得多，从而能够简单，有效和实用地制备相应的有机磷化合物。

  DOI：

  10.1039/c9gc01254k

文献信息

• Cyclische Ester und Thioester von Phosphon-, Thiophosphon- und Selenophosphons�uren
  作者：M. Wieber、H. U. Werther

  DOI：10.1007/bf00913774

  日期：——
• Ovchinnikov, V. V.; Brus'ko, V. V.; Cherkasov, R. A., Russian Journal of General Chemistry, 1993, vol. 63, # 3.2, p. 499 - 500
  作者：Ovchinnikov, V. V.、Brus'ko, V. V.、Cherkasov, R. A.

  DOI：——

  日期：——
• MORITA, IWAO;TSUDA, MASAMI;KISE, MASAHIRO;SUGIYAMA, MAKOTO, CHEM. AND PHARM. BULL., 35,(1987) N 12, 4711-4716
  作者：MORITA, IWAO、TSUDA, MASAMI、KISE, MASAHIRO、SUGIYAMA, MAKOTO

  DOI：——

  日期：——
• Process for Producing 1,2-Trans-Glycoside Compound
  申请人：Yamago Shigeru

  公开号：US20080177049A1

  公开（公告）日：2008-07-24

  In preparing a glycoside compound from (a) a furanose compound or pyranose compound, and (b) an alcohol compound, a process for preparing a glycoside compound in which glycosidic bond locates selectively trans form relative to C-2 hydroxyl group, the process comprising using a furanose compound wherein the hydroxyl at the 2-position may have a substituent protected with a group A, or a pyranose compound which may have a substituent wherein R 2 and R 3 are the same or different and are each alkyl having 1 to 4 carbon atoms or aryl having or not having a substituent, or R 2 and R 3 are combined to form alkylene having 2 to 4 carbon atoms (the alkylene may be substituted with alkyl having 1 to 4 carbon atoms, or may have intervening phenylene), and m and n are each an integer of 0 or 1.
• PROCESS FOR PRODUCING 1,2-TRANS-GLYCOSIDE COMPOUND
  申请人：Yamago Shigeru

  公开号：US20120232256A1

  公开（公告）日：2012-09-13

  In preparing a glycoside compound from (a) a furanose compound or pyranose compound, and (b) an alcohol compound, a process for preparing a glycoside compound in which glycosidic bond locates selectively trans form relative to C-2 hydroxyl group, the process comprising using a furanose compound wherein the hydroxyl at the 2-position may have a substituent protected with a group A, or a pyranose compound which may have a substituent wherein R 2 and R 3 are the same or different and are each alkyl having 1 to 4 carbon atoms or aryl having or not having a substituent, or R 2 and R 3 are combined to form alkylene having 2 to 4 carbon atoms (the alkylene may be substituted with alkyl having 1 to 4 carbon atoms, or may have intervening phenylene), and m and n are each an integer of 0 or 1.