N-(2-methylpropylidene)hexan-1-amine | 71451-17-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-methylpropylidene)hexan-1-amine
• 英文别名: N-hexyl-2-methylpropane-1-imine；N-hexyl-2-methylpropan-1-imine
• CAS: 71451-17-7
• 化学式: C₁₀H₂₁N
• 分子量: 155.283
• InChiKey: XRCSPQGZTFNGMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(2-methylpropylidene)hexan-1-amine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 N-(2-甲基丙基)己烷-1-胺
  参考文献：
  名称：

  A Convergent One-Pot Synthesis of Secondary Amines via Aza-Wittig Reaction

  摘要：

  Secondary amines are obtained in moderate-good yields by reduction of crude imines prepared from N-alkyltriethoxyiminophosphoranes and aldehydes via the aza-Wittig reaction. N-Alkyltriethoxyiminophosphoranes are synthesized by one-pot azidation of alkyl bromides followed by Staudinger reaction.

  DOI：

  10.1080/00397919208021323
• 作为产物：
  描述：

  己基叠氮化物 以 苯 为溶剂， 反应 3.0h， 生成 N-(2-methylpropylidene)hexan-1-amine
  参考文献：
  名称：

  A Convergent One-Pot Synthesis of Secondary Amines via Aza-Wittig Reaction

  摘要：

  Secondary amines are obtained in moderate-good yields by reduction of crude imines prepared from N-alkyltriethoxyiminophosphoranes and aldehydes via the aza-Wittig reaction. N-Alkyltriethoxyiminophosphoranes are synthesized by one-pot azidation of alkyl bromides followed by Staudinger reaction.

  DOI：

  10.1080/00397919208021323

文献信息

• Catalytic coupling of nitriles with amines to selectively form imines under mild hydrogen pressure
  作者：Dipankar Srimani、Moran Feller、Yehoshoa Ben-David、David Milstein

  DOI：10.1039/c2cc36639h

  日期：——

  Imines are selectively formed by coupling of nitriles and amines under mild hydrogen pressure. The reaction is catalyzed by a bipyridine-based PNN Ru(II) pincer complex and proceeds under mild, neutral conditions at 4 bar of H(2).

  亚胺是通过在适度的氢气压力下将腈和胺偶联而选择性形成的。该反应由基于联吡啶的PNN Ru（II）夹杂物催化，并在4 bar H（2）的温和中性条件下进行。
• Colloidal and Nanosized Catalysts in Organic Synthesis: XXIII. Reductive Amination of Carbonyl Compounds Catalyzed by Nickel Nanoparticles in a Plug-Flow Reactor
  作者：V. M. Mokhov、Yu. V. Popov、A. N. Paputina、D. N. Nebykov、E. V. Shishkin

  DOI：10.1134/s1070363219120016

  日期：2019.12

  Reductive amination of aldehydes and ketones with primary and secondary amines under catalysis with nickel nanoparticles supported on zeolite X, MgO, or activated carbon in the gas phase or in the gas-liquid system in a plug-flow reactor proceeds at atmospheric pressure of hydrogen with the formation of secondary or tertiary amines in high yield.

  在活塞流式反应器中，在气相或气液系统中，负载在沸石X，MgO或活性炭上的镍纳米粒子在催化下，用伯胺和仲胺对醛和酮进行还原性胺化反应，在氢气的大气压下进行。高产率地形成仲胺或叔胺。
• A Convenient Preparation and Utilization of Lithium Dialkylamides
  作者：F. Gaudemar-Bardone、M. Gaudemar

  DOI：10.1055/s-1979-28721

  日期：——
• A Convergent One-Pot Synthesis of Secondary Amines via Aza-Wittig Reaction
  作者：Gajda、Koziara、Osowska-Pacewicka、Zawadzki、Zwierzak

  DOI：10.1080/00397919208021323

  日期：1992.7

  Secondary amines are obtained in moderate-good yields by reduction of crude imines prepared from N-alkyltriethoxyiminophosphoranes and aldehydes via the aza-Wittig reaction. N-Alkyltriethoxyiminophosphoranes are synthesized by one-pot azidation of alkyl bromides followed by Staudinger reaction.