N~1~-(3-Aminopropyl)-N~4~-[3-(methylamino)propyl]butane-1,4-diamine | 100242-25-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N~1~-(3-Aminopropyl)-N~4~-[3-(methylamino)propyl]butane-1,4-diamine
• 英文别名: N-(3-aminopropyl)-N'-[3-(methylamino)propyl]butane-1,4-diamine
• CAS: 100242-25-9
• 化学式: C₁₁H₂₈N₄
• 分子量: 216.37
• InChiKey: YZQIXDNUIPBJHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(4,9,13-tritosyl-4,9,13-triazatetradecyl)phthalimide 、 氢溴酸 生成 N~1~-(3-Aminopropyl)-N~4~-[3-(methylamino)propyl]butane-1,4-diamine
  参考文献：
  名称：

  KIEDROWSKI, GUNTER VON;ZARAGOZA, DORWALD FLORENCIO, LIEBIGS ANN. CHEM.,(1988) N 8, C. 787-794

  摘要：

  DOI：

文献信息

• [EN] SURFACE TREATMENTS<br/>[FR] TRAITEMENTS DE SURFACE
  申请人：BOVIN NICOLAI VLADIMIROVICH

  公开号：WO2016185331A1

  公开（公告）日：2016-11-24

  Methods of treating surfaces to provide an antibacterial surface or a surface to which micro-dimensioned particles will adhere are disclosed. Water dispersible selenide-lipid and polycation-lipid constructs for use in the methods are also disclosed.

  公开了用于提供抗菌表面或微维粒子附着表面的处理表面的方法。还公开了用于这些方法的可水分散的硒脂和阳离子脂质构建物。
• AMIDE DERIVATIVES OF SQUALAMINE FOR THE TREATMENT OF INFECTIONS
  申请人：VIRBAC

  公开号：US20190262362A1

  公开（公告）日：2019-08-29

  A compound of formula (I) in which R′ represents a group —(CR a R b ) n —X—(CR c R d ) m —[Y—(CR e R f ) o ] t —NR 9 R 10 and X and Y independently represent a group —NR11-, a group —O— or a divalent 5-membered or 6-membered heterocyclic group comprising at least one nitrogen atom, and also the stereoisomers, mixtures of stereoisomers, and/or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical or veterinary compositions containing the compound of formula (I) and also to the use thereof as medicament, more particularly in the treatment of bacterial, fungal, viral or parasitic infections. Also further disclosed are pharmaceutical or veterinary compositions including the compound of formula (I) in combination with an antibiotic other than such a compound of formula (I).

  化合物的公式(I)，其中R′代表一个基团- (CRaRb)n-X-(CRcRd)m-[Y-(CReRf)o]t-NR9R10，X和Y分别代表一个基团-NR11-，一个基团-O-或者至少包含一个氮原子的二价五元或六元杂环基团，以及其立体异构体、立体异构体混合物和/或药学上可接受的盐。还公开了包含公式(I)化合物的制药或兽医组合物，以及在治疗细菌、真菌、病毒或寄生虫感染方面作为药物的用途。还公开了包含公式(I)化合物和除公式(I)化合物以外的抗生素的制药或兽医组合物。
• HYALURONIC ACID DERIVATIVE HAVING CATIONIC GROUP AND HYDROPHOBIC GROUP INTRODUCED THEREIN
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP3456745A1

  公开（公告）日：2019-03-20

  The present invention provides hyaluronic acid derivatives into which a certain cationic group and a certain hydrophobic group are introduced, the hyaluronic acid derivatives including one or more repeating units represented by the formula (Ia) and one or more repeating units represented by the formula (Ib).

  本发明提供了引入一定阳离子基团和一定疏水基团的透明质酸衍生物，透明质酸衍生物包括一个或多个由式（Ia）表示的重复单元和一个或多个由式（Ib）表示的重复单元。
• COMPOSITION FOR ORAL DELIVERY COMPRISING MGBG FOR USE IN TREATING MULTIPLE SCLEROSIS
  申请人：Pathologica LLC

  公开号：EP3473247A1

  公开（公告）日：2019-04-24

  The present invention relates to an oral pharmaceutical composition, comprising methylglyoxal bis(guanylhydrazone) (MGBG) together with at least one oral pharmaceutically acceptable excipient, for use in the treatment or delaying the onset or development of multiple sclerosis when orally administered to a subject.

  本发明涉及一种口服药物组合物，包括甲基乙二醛双（鸟苷腙）（MGBG）和至少一种口服药物可接受赋形剂，用于口服给受试者治疗或延缓多发性硬化症的发作或发展。
• HYALURONIC ACID DERIVATIVE MODIFIED WITH POLY(ETHYLENE GLYCOL)
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP3712181A1

  公开（公告）日：2020-09-23

  The present invention provides hyaluronic acid derivatives including one or more of each of repeating units represented by the formulae (Ia), (Ib), and (Ic) in which certain cationic sites, certain hydrophobic sites, and certain hydrophilic sites have been introduced. In addition, the present invention provides complexes of the hyaluronic acid derivatives with a drug and pharmaceutical compositions including the hyaluronic acid derivatives, in particular, complexes of the hyaluronic acid derivatives with a drug.

  本发明提供了透明质酸衍生物，包括式(Ia)、(Ib)和(Ic)所代表的重复单元中的每个单元中的一个或多个，其中引入了某些阳离子位点、某些疏水位点和某些亲水位点。此外，本发明还提供了透明质酸衍生物与药物的复合物以及包括透明质酸衍生物的药物组合物，特别是透明质酸衍生物与药物的复合物。