N-n-Pentyl-N-(2-hydroxypropyl)amin | 41063-36-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-n-Pentyl-N-(2-hydroxypropyl)amin
• 英文别名: 1-(Pentylamino)-2-propanol；1-(pentylamino)propan-2-ol
• CAS: 41063-36-9
• 化学式: C₈H₁₉NO
• mdl: MFCD11934334
• 分子量: 145.245
• InChiKey: GJLXSQMDBRASLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-n-Pentyl-N-(2-hydroxypropyl)amin 在 吡啶 、 chromium(VI) oxide 作用下， 以 二氯甲烷 为溶剂， 生成 N-amyl-N-(2-oxopropyl)nitrosamine
  参考文献：
  名称：

  Syntheses of N-alkyl-N-(hydroxy- or oxo-alkyl)nitrosamines related to N-butyl-N-(4-hydroxybutyl)nitroamine, a potent bladder carcinogen.

  摘要：

  为研究其在大鼠体内的致癌效应，合成了19种与N-丁基-N-(4-羟基丁基)亚硝胺（一种强效膀胱致癌物）结构相关的N-烷基-N-(羟基或氧代烷基)亚硝胺。这些亚硝胺包括N-烷基-N-(4-羟基丁基)亚硝胺、N-烷基-N-(3-羟基丙基)亚硝胺、N-烷基-N-(2-羟基烷基)亚硝胺以及N-烷基-N-(2-或3-氧代烷基)亚硝胺。它们主要通过相应N-烷基-N-(羟基烷基)胺的亚硝化反应制备。含有氧代基团的亚硝胺则通过铬酐氧化相应的具有次级羟基的N-烷基-N-(羟基烷基)亚硝胺制备。

  DOI：

  10.1248/cpb.26.3891
• 作为产物：
  描述：

  1-氨基戊烷 、 methyloxirane 在 scandium tris(trifluoromethanesulfonate) 作用下， 反应 12.0h， 以20%的产率得到N-n-Pentyl-N-(2-hydroxypropyl)amin
  参考文献：
  名称：

  Scandium triflate as an efficient and useful catalyst for the synthesis of β-amino alcohols by regioselective ring opening of epoxides with amines under solvent-free conditions

  摘要：

  A simple and efficient method has been developed for the synthesis of P-amino alcohols by ring opening of epoxides in the presence of a catalytic amount of Sc(OTf)(3) at room temperature under solvent-free conditions. The reaction works well with both aromatic and aliphatic amines. High regio-, and diastereoselectivity can be considered as a noteworthy advantage of this method. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.106

文献信息

• [EN] NOVEL METHOD OF USE AND COMPOSITIONS<br/>[FR] NOUVEAU PROCÉDÉ D'UTILISATION ET COMPOSITIONS
  申请人：GLAXOSMITHKLINE CONSUMER HEALTHCARE HOLDINGS (US) LLC

  公开号：WO2017074902A1

  公开（公告）日：2017-05-04

  The present invention is directed to a method for improving the occlusiveness of a topical pharmaceutical or cosmetic formulation in use in a patient in need thereof, comprising adding to the formulation at least 0.1- to about 10% w/w of one or more of a monofatty acid ester of glycerin and/or one or more of a monofatty acid ester of glycol, or mixtures thereof. The present invention is also directed to a method for maintaining skin barrier efficiency of the stratum corneum of a patient in need thereof, comprising applying to the skin of said patient a pharmaceutical or cosmetic formulation containing at least 3 % w/w of one or more of a monofatty acid ester of glycerin and/or one or more of a monofatty acid ester of glycol, or mixtures thereof.

  本发明涉及一种用于改善患者使用中的局部药物或化妆品配方的闭合性的方法，包括向配方中添加至少0.1%至约10%重量/重量的一种或多种甘油的单脂肪酸酯和/或一种或多种乙二醇的单脂肪酸酯，或其混合物。本发明还涉及一种用于维持患者角质层皮肤屏障效率的方法，包括向该患者的皮肤上涂抹含有至少3%重量/重量的一种或多种甘油的单脂肪酸酯和/或一种或多种乙二醇的单脂肪酸酯，或其混合物的药物或化妆品配方。
• Process for producing optically active n-aryl-1-amino-2-propanol derivatives
  申请人：——

  公开号：US20040116709A1

  公开（公告）日：2004-06-17

  The present invention has an object to provide a process for easily producing optically active N-aryl-1-amino-2-propanol derivatives which are of value as pharmaceutical intermediates from inexpensive starting materials. The above object can be attained by producing an optically active N-aryl-1-amino-2-propanol derivative by the process which comprises reacting an optically active lactate derivative or an optically active lactic acid acetal derivative, which are available at low cost, with an arylamine derivative to give an optically active N-aryllactamide derivative and treating it with a reducing agent.

  本发明旨在提供一种从廉价原料中轻松生产具有药物中间体价值的光学活性N-芳基-1-氨基-2-丙醇衍生物的方法。以上目标可以通过以下方法实现：通过将低成本的光学活性乳酸酯衍生物或光学活性乳酸醛缩衍生物与芳基胺衍生物反应，得到光学活性N-芳基乳酰胺衍生物，并用还原剂处理它，从而生产出光学活性N-芳基-1-氨基-2-丙醇衍生物。
• Pharmazeutisches und/oder kosmetisches Mittel, das eine Mischung von N-Acyl-alkanolaminen mit N-Acylphospholipiden oder Lysophospholipiden enthält
  申请人：RHONE-POULENC RORER GMBH

  公开号：EP0606590A1

  公开（公告）日：1994-07-20

  Es wird ein pharmazeutisches und/oder kosmetisches Mittel beschrieben, wobei das Mittel als Wirkstoff neben ggf. üblichen Zusatzstoffen eine Mischung von N-Acyl-Alkanolaminen mit N-Acyl-Ethanolaminen enthält.

  描述了一种药物和/或化妆品组合物，其中除了任何常规添加剂外，该组合物还含有一种以 N-酰基乙醇胺为活性成分的 N-酰基乙醇胺混合物。
• 1,3-Dialkyl-2-imidazolidinones and a manufacturing process therefor
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0992497A1

  公开（公告）日：2000-04-12

  1,3-dialkyl-2-imidazolidinones are made by a process involving a direct one-step reaction from industrially available alkylene carbonate, N-alkylethanolamine or 1,2-diol; the process can minimize formation of solid material and can be readily conducted in a large-scale industrial production with high yield and few byproducts. The process is characterized in that alkylene carbonate, N-alkylethanolamine or 1,2-diol is reacted with monoalkylamine and carbon dioxide, alkylcarbamate alkylamine salt, and/or 1,3-dialkyurea, by heating them at 50°C or higher in a reactor whose area in contact with at least part of the reactants and/or products is made of a metal comprising titanium or zirconium and/or an oxide thereof, or an inorganic glass.

  1,3-二烷基-2-咪唑烷酮是由工业上可获得的碳酸亚烷基酯、N-烷基乙醇胺或 1,2-二醇直接一步反应制得的；该工艺可最大限度地减少固体物质的形成，并易于进行大规模工业生产，产量高，副产品少。该工艺的特点是：碳酸亚烷基酯、N-烷基乙醇胺或 1,2-二醇与单烷基胺和二氧化碳、烷基氨基甲酸酯烷基胺盐和/或 1,3-二基脲在 50°C 或更高温度下在反应器中加热反应，反应器与至少部分反应物和/或产物接触的区域由钛或锆和/或其氧化物组成的金属或无机玻璃制成。
• 1,3-dialkyl-2-imidazolidinones and a manufacturing process therefor
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP1148051A2

  公开（公告）日：2001-10-24

  1,3-dialkyl-2-imidazolidinones are made by a process involving a direct one-step reaction from industrially available alkylene carbonate, N-alkylethanolamine or 1,2-diol; the process can minimize formation of solid material and can be readily conducted in a large-scale industrial production with high yield and few byproducts. The process is characterized in that alkylene carbonate, N-alkylethanolamine or 1,2-diol is reacted with monoalkylamine and carbon dioxide, alkylcarbamate alkylamine salt, and/or 1,3-dialkyurea, by heating them at 50°C or higher in a reactor whose area in contact with at least part of the reactants and/or products is made of a metal comprising titanium or zirconium and/or an oxide thereof, or an inorganic glass.

  1,3-二烷基-2-咪唑烷酮是由工业上可获得的碳酸亚烷基酯、N-烷基乙醇胺或 1,2-二醇直接一步反应制得的；该工艺可最大限度地减少固体物质的形成，并易于进行大规模工业生产，产量高，副产品少。该工艺的特点是：碳酸亚烷基酯、N-烷基乙醇胺或 1,2-二醇与单烷基胺和二氧化碳、烷基氨基甲酸酯烷基胺盐和/或 1,3-二基脲在 50°C 或更高温度下在反应器中加热反应，反应器与至少部分反应物和/或产物接触的区域由钛或锆和/或其氧化物组成的金属或无机玻璃制成。