1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-iodopyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-iodopyrimidine-2,4-dione
• 英文别名: 1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
• 化学式: C₉H₁₁IN₂O₅
• 分子量: 354.1
• InChiKey: XQFRJNBWHJMXHO-JXBXZBNISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  99.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• METHODS OF SYNTHESIZING LABELED NUCLEOSIDES
  申请人：Singular Genomics Systems, Inc.

  公开号：US20190077726A1

  公开（公告）日：2019-03-14

  Disclosed herein, inter alia, are compounds, compositions, and methods of synthesizing labeled nucleosides.

  在此披露的内容包括化合物、组合物和合成标记核苷的方法。
• RADIOLABELED NUCLEOSIDE ANALOGUE, AND PREPARATION METHOD AND USE THEREOF
  申请人：WANG HSIN-ELL

  公开号：US20120178919A1

  公开（公告）日：2012-07-12

  A radiolabeled nucleoside analogue is provided, which includes radioactive iodine 123 I/ 131 I, and a nucleoside analogue selected from a group consisting of cytidine, thymidine, uridine, and a derivative thereof. A method for preparing the radiolabeled nucleoside analogue, and a use thereof are further provided. The nucleoside analogue, prepared through the preparation method with a short synthesis time and a high radiochemical yield, has a long in vivo physiological half life and a high stability in serum, and, as a radiopharmaceutical composition, is useful in development of tumor proliferation diagnosis or therapy prognosis evaluation, and further assists in observation of long-time in vivo metabolism of a drug.

  提供了一种放射性标记的核苷类似物，包括放射性碘123I/131I，以及从胞嘧啶、胸苷、尿苷和其衍生物组成的一组中选择的核苷类似物。还提供了一种制备放射性标记的核苷类似物的方法以及其用途。通过具有短合成时间和高放射化学产率的制备方法制备的核苷类似物，在体内具有长的生理半衰期和高的血清稳定性，作为一种放射性药物组合物，有助于肿瘤增殖诊断或治疗预后评估的发展，并进一步帮助观察药物的长期体内代谢。
• METHODS FOR ARRANGING AND PACKING NUCLEIC ACIDS FOR UNUSUAL RESISTANCE TO NUCLEASES AND TARGETED DELIVERY FOR GENE THERAPY
  申请人：The Regents of the University of California

  公开号：US20150190525A1

  公开（公告）日：2015-07-09

  There are disclosed compositions and methods to render nucleic acids resistant to nuclease digestion while maintaining sequence selective hybridization competency. The approach relies on utilizing nucleic acids as the polar head group of a nucleic acid-polymer amphiphile in order to assemble well-defined, discrete micellar nanoparticles. Dense packing of nucleic acid in the micelle corona allows for hybridization of complementary oligonucleotides while prohibiting enzymatic degradation.

  本文披露了一种使核酸在维持序列选择性杂交能力的同时抵抗核酸酶消化的组合物和方法。该方法依赖于利用核酸作为核酸-聚合物两性分子的极性头基，以组装明确定义的离散胶束纳米粒子。在胶束包层中核酸的密集包装允许互补寡核苷酸的杂交，同时禁止酶降解。
• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE<br/>[FR] COMPOSÉS, COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE MALADIE
  申请人：SPEROVIE BIOSCIENCES INC

  公开号：WO2018013908A1

  公开（公告）日：2018-01-18

  This invention relates to compounds and compositions for the induction of expression of a pattern recognition receptor (e.g., STING) and methods of use thereof.

  这项发明涉及用于诱导模式识别受体（例如STING）表达的化合物和组合物，以及其使用方法。
• [EN] DISULFIDE-LINKED REVERSIBLE TERMINATORS<br/>[FR] TERMINATEURS RÉVERSIBLES À LIAISON DISULFURE
  申请人：CENTRILLION TECH INC

  公开号：WO2020069424A1

  公开（公告）日：2020-04-02

  The present disclosure provides methods of sequencing polynucleotides and compounds, compositions useful for sequencing of polynucleotides. The chemical compounds include nucleotides and their analogs which possess a sugar moiety comprising a cleavable chemical group capping the 3'-OH group and a base that is attached to a detectable label through a cleavable linker comprising a disulfide bond. In addition, the disulfide bond(s) can be cleavable by a reducing reagent. In addition, after the disulfide bond(s) is/are cleaved by the reducing reagent, there is no free thiol group linked to the nucleotides. Examples of chemical compounds according to the present disclosure are shown as Formulae (IV) and (V).

  本公开提供了测序多核苷酸的方法以及用于测序多核苷酸的化合物和组合物。这些化学化合物包括核苷酸及其类似物，其具有糖基团，包括覆盖3'-OH基团的可裂解化学基团和与可裂解连接剂通过二硫键连接的可检测标签的碱基。此外，二硫键可以被还原试剂裂解。在二硫键被还原试剂裂解后，没有自由巯基与核苷酸连接。根据本公开的化学化合物的示例如公式（IV）和（V）。