4-(morpholin-4-yl)pyridine N-oxide | 74415-02-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(morpholin-4-yl)pyridine N-oxide
• 英文别名: 4-(4-morpholinyl)pyridine 1-oxide；4-(4-morpholino)pyridine 1-oxide；4-(N-morpholino)pyridine N-oxide；4-morpholinopyridine N-oxide；4-(4-oxy-pyridin-4-yl)-morpholine；4-Morpholino-pyridin-1-oxid；4-(1-Oxidopyridin-4-yl)morpholine；4-(1-oxidopyridin-1-ium-4-yl)morpholine
• CAS: 74415-02-4
• 化学式: C₉H₁₂N₂O₂
• mdl: MFCD01606127
• 分子量: 180.206
• InChiKey: PDWAYYILCFDABM-UHFFFAOYSA-N

物化性质

• 熔点：
  75-78 °C(Solv: acetone (67-64-1))
• 沸点：
  421.5±35.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.444
• 拓扑面积：
  37.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(morpholin-4-yl)pyridine N-oxide 在 锌 作用下， 以 溶剂黄146 为溶剂， 反应 3.0h， 以63%的产率得到4-吗啉吡啶
  参考文献：
  名称：

  1-烷基-4-二烷基氨基吡啶鎓卤化物在二氯卡宾反应中作为相转移催化剂

  摘要：

   合成了一系列衍生自4-二甲基氨基和4-吗啉代吡啶的1-烷基-4-二烷基氨基吡啶鎓卤化物，并在二氯卡宾的三个典型反应中作为相转移催化剂进行了测试：苯甲酰胺的脱水，二苯胺的N-甲酰化和二氯胺的二氯环丙烷化苯乙烯。发现上述化合物的催化性能与常规的季铵催化剂相当或更高。评价了催化剂结构对反应性的影响。

  DOI：

  10.1007/s007060200009
• 作为产物：
  描述：

  4-硝基吡啶-N-氧化物 在 水 作用下， 生成 4-(morpholin-4-yl)pyridine N-oxide
  参考文献：
  名称：

  RECENT JAPANESE WORK ON THE CHEMISTRY OF PYRIDINE 1-OXIDE AND RELATED COMPOUNDS¹

  摘要：

  DOI：

  10.1021/jo01133a010

文献信息

• Complex formation between derivatives of pyridine N-oxides and iron(III) nitrate in aqueous medium
  作者：A. V. Ryzhakov、V. P. Andreev

  DOI：10.1134/s1070363216010163

  日期：2016.1

  Donor-acceptor complexes of derivatives of pyridine N-oxides with iron(III) nitrate have been studied. Their stability constants in water and in aqueous acetone have been determined. The complexes stability increases upon heating, at decreasing solvent polarity, and in the presence of the substituents in the N-oxide ring.

  研究了吡啶N-氧化物与硝酸铁（III）衍生物的供体-受体配合物。已经确定了它们在水和丙酮水溶液中的稳定性常数。在加热，溶剂极性降低和N-氧化物环中存在取代基的情况下，配合物的稳定性增加。
• Oligonucleotide analogues, methods of synthesis and methods of use
  申请人：——

  公开号：US20020155989A1

  公开（公告）日：2002-10-24

  The present invention relates generally to oligonucleotide analogues that include novel protein nucleic acid molecules (PNAs), particularly monomers, dimers, oligomers thereof and methods of making and using these oligonucleotide analogues. The PNAs of the present invention are characterized as including a variety of classes of molecules, such as, for example, hydroxyproline peptide nucleic acids (HypNA), and serine peptide nucleic acids (SerNA). The invention includes monomers, homodimers, heterodimers, homopolymers and heteropolymers of these and other oligonucleotide analogues. The present invention includes methods of using these oligonucleotide analogues in the detection and separating of nucleic acid molecules, including uses that include the utilization of oligonucleotide analogues on a solid support. The present invention also includes methods for purifying or separating nucleic acids, such as mRNA molecules, by hybridization with the oligonucleotides of the present invention. The present invention also includes the use of oligonucleotides of the present invention in antisense and homologous recombination constructs and methods.

  本发明一般涉及包括新型蛋白质核酸分子（PNAs）的寡核苷酸类似物，特别是其单体、二聚体、寡聚体以及制造和使用这些寡核苷酸类似物的方法。本发明的 PNAs 包括多种分子类别，例如羟脯氨酸肽核酸（HypNA）和丝氨酸肽核酸（SerNA）。本发明包括这些寡核苷酸和其他寡核苷酸类似物的单体、同源二聚体、异源二聚体、均聚物和异聚物。本发明包括使用这些寡核苷酸类似物检测和分离核酸分子的方法，包括在固体支持物上使用寡核苷酸类似物。本发明还包括通过与本发明的寡核苷酸杂交来纯化或分离核酸（如 mRNA 分子）的方法。本发明还包括本发明寡核苷酸在反义和同源重组构建物和方法中的使用。
• Oligonucleotide analogues and methods of use for modulating gene expression
  申请人：——

  公开号：US20040014644A1

  公开（公告）日：2004-01-22

  The present invention relates generally to oligonucleotide analogues that include novel protein nucleic acid molecules (PNAs), particularly monomers, dimers, oligomers thereof and methods of making and using these oligonucleotide analogues. The PNAs of the present invention are characterized as including a variety of classes of molecules, such as, for example, hydroxyproline peptide nucleic acids (HypNA), and serine peptide nucleic acids (SerNA). The present invention also includes the use of oligonucleotides of the present invention in antisense and homologous recombination constructs and methods.

  本发明一般涉及包括新型蛋白质核酸分子（PNAs）的寡核苷酸类似物，特别是其单体、二聚体、寡聚体以及制造和使用这些寡核苷酸类似物的方法。本发明的 PNAs 包括多种分子类别，例如羟脯氨酸肽核酸（HypNA）和丝氨酸肽核酸（SerNA）。本发明还包括在反义和同源重组构建物和方法中使用本发明的寡核苷酸。
• Battye, Peter J.; Ihsan, Ekmel M.; Moodie, Roy B., Journal of the Chemical Society. Perkin transactions II, 1980, p. 741 - 748
  作者：Battye, Peter J.、Ihsan, Ekmel M.、Moodie, Roy B.

  DOI：——

  日期：——
• Equilibrium of acyl transfer between pyridine N-oxides and their acylonium salts
  作者：V. I. Rubachenko、G. Schroeder、K. Yu. Chotii、V. V. Kovalenko、A. N. Red’ko、B. Lenska

  DOI：10.1134/s1070363208060248

  日期：2008.6

  TransFer of' acyl groups from N-acyloxypyridinium salts to pyridine N-oxides in acetonitrile was studied. The equilibrium constants of' acyl exchange were determined. These quantities vary in the range coverino ei,,ht orders of magnituJe, depending on the structure of the reavents. and are independent of' the z' c C C structure ol'the acyl group.