N,N'-diphenyl-1,5-diamino-3-oxapentane | 75953-71-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-diphenyl-1,5-diamino-3-oxapentane
• 英文别名: bis-(2-anilino-ethyl)-ether；β.β'-Dianilino-diaethylaether；Bis-(2-anilino-aethyl)-aether；N-[2-(2-anilinoethoxy)ethyl]aniline
• CAS: 75953-71-8
• 化学式: C₁₆H₂₀N₂O
• 分子量: 256.348
• InChiKey: IQLAPAZTTZGWKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  33.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N'-diphenyl-1,5-diamino-3-oxapentane 在 吡啶 、 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 10.0h， 生成 1,7,13,19-tetraphenyl-4,10,16,22-tetraoxa-1,7,13,19-tetraazacyclotetraeicosane
  参考文献：
  名称：

  Synthesis of some 24-membered tetralactam derivatives by an unexpectedly simple route, and some macrocyclic polyether dilactams

  摘要：

  An unexpected reaction of 1,5-bis(arylamino)-3-oxapentanes 4, 21 and 22 with diglycolyl dichloride gave 24-membered macrocyclic tetralactams 18, 23 and 24 respectively, in a reaction involving two molecules of each reactant (2:2 process). This was in contrast to closely related reactions of alpha,omega-bis(arylamino)alkylethers 5 and 6 with diglycolyl, triglycolyl and tetraglycolyl dichlorides which yielded the macrocycles 9-14 by reaction of one molecule of each reactant (1:1 process). The phenyl nuclei in 14 and 18 were formylated to give 34, 35 and 36. The aldehydes, 35 and 36 were condensed with a quinoxaline fluorophore to yield the diene 37 and the tetraene 38 respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00892-3
• 作为产物：
  描述：

  二甘醇酸二苯胺 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以78%的产率得到N,N'-diphenyl-1,5-diamino-3-oxapentane
  参考文献：
  名称：

  Synthesis of some 24-membered tetralactam derivatives by an unexpectedly simple route, and some macrocyclic polyether dilactams

  摘要：

  An unexpected reaction of 1,5-bis(arylamino)-3-oxapentanes 4, 21 and 22 with diglycolyl dichloride gave 24-membered macrocyclic tetralactams 18, 23 and 24 respectively, in a reaction involving two molecules of each reactant (2:2 process). This was in contrast to closely related reactions of alpha,omega-bis(arylamino)alkylethers 5 and 6 with diglycolyl, triglycolyl and tetraglycolyl dichlorides which yielded the macrocycles 9-14 by reaction of one molecule of each reactant (1:1 process). The phenyl nuclei in 14 and 18 were formylated to give 34, 35 and 36. The aldehydes, 35 and 36 were condensed with a quinoxaline fluorophore to yield the diene 37 and the tetraene 38 respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00892-3

文献信息

• 화합물, 이를 포함하는 코팅 조성물 및 유기 발광 소자
  申请人：LG CHEM, LTD. 주식회사 엘지화학(120010134563) Corp. No ▼ 110111-2207995BRN ▼107-81-98139

  公开号：KR20180131457A

  公开（公告）日：2018-12-10

  본 명세서는 화합물, 이를 포함하는 코팅 조성물 및 유기 발광 소자에 관한 것이다.

  本规范涉及化合物、包含其的涂料组合物和有机发光器件。
• Eingedickte Formmassen
  申请人：BASF Aktiengesellschaft

  公开号：EP0308745A2

  公开（公告）日：1989-03-29

  Die Erfindung betrifft eine eingedickte, unvernetzte, lagerstabile, oberhalb von 50°C härtbare Formmasse aus einem flüssigen Reaktivsystem, einem Eindickmittel, einem Polymerisationsinitiator und üblichen Zusatzstoffen. Das Eindickmittel ist eine Kombination aus einem primären aromatischen Amin und einem Isocyanat. Die Formmassen, die insbesondere als SMC- oder BMC-Massen vorliegen, können durch Pressen, Spritzgießen oder Spritzpressen und anschließendes Aushärten zu Formteilen verarbeitet werden.

  本发明涉及一种可在 50°C 以上固化的增稠、非交联、贮存稳定的模塑化合物，由液 体反应体系、增稠剂、聚合引发剂和常规添加剂组成。增稠剂是芳香族伯胺和异氰酸酯的混合物。模塑化合物，尤其是 SMC 或 BMC 化合物，可通过压制、注塑或注塑压缩成型以及随后的固化工艺加工成模塑部件。
• Olefin polymerization catalysts and olefin polymer production methods using said olefin polymerization catalysts
  申请人：JSR Corporation

  公开号：EP1046654A1

  公开（公告）日：2000-10-25

  An object of this invention is to provide a polymerization catalyst that can be used for the polymerization of olefins. Another object of this invention is to present a method of producing excellent olefin polymers with high copolymerization properties and high molecular weight using the polymerization catalyst. The catalyst of this invention is an olefin polymerization catalyst which contains a reaction product obtained from vanadium oxytrichloride and 2,2'-thiobis(6-5-butyl-4-methylphenyl), an organic aluminum compound, such as trimethylaluminum, and an ionized ionic compound, such as N,N-dimethylanilinium tetrakis(pentafluorophenyl)borate, and the like. By using this catalyst to polymerize ethylene with an α-olefin, such as propylene, 1-heptene, 1-octene, and the like., or a non-conjugated diene, such as 5-ethylidene-2-norbornene, and the like., a polymer of high copolymerization properties can be obtained.

  本发明的一个目的是提供一种可用于烯烃聚合的聚合催化剂。本发明的另一个目的是提出一种使用该聚合催化剂生产具有高共聚合性能和高分子量的优良烯烃聚合物的方法。本发明的催化剂是一种烯烃聚合催化剂，它含有由三氯氧钒和 2,2'-硫代双（6-5-丁基-4-甲基苯基）、有机铝化合物（如三甲基铝）和离子化离子化合物（如 N,N-二甲基苯胺四（五氟苯基）硼酸酯）等得到的反应产物。使用这种催化剂使乙烯与α-烯烃（如丙烯、1-庚烯、1-辛烯等）或非共轭二烯（如 5-亚乙基-2-降冰片烯等）聚合，可获得共聚性能高的聚合物。
• Combination of a beta-2 adrenoceptor agonist and an aminosugar and their use for the treatment of immunomodulatory disorders
  申请人：Astion Development A/S

  公开号：EP1642574A2

  公开（公告）日：2006-04-05

  The invention relates to combinations of an aminosugar and a beta-2 adrenoceptor agonist, such as salbutamol, for the treatment of diseases associated with hypersensitivity and inflammation, in particular hypersensitivity skin diseases. The aminosugar is preferably a monosaccharide derivative.

  本发明涉及一种氨基糖和β-2肾上腺素受体激动剂（如沙丁胺醇）的组合，用于治疗与超敏性和炎症有关的疾病，特别是超敏性皮肤病。氨基糖最好是单糖衍生物。
• Beta-2 adrenoceptor agonists for treating connective tissue diseases of the skin
  申请人：Astion Development A/S

  公开号：EP1719507A1

  公开（公告）日：2006-11-08

  The present invention provides effective and safe medicaments for the treatment of connective tissue diseases of the skin, particularly with respect to the treatment of cutaneous forms of Lupus Erythematous. The medicaments comprise as the therapeutically active ingredient a beta2 adrenoceptor agonist. The invention furthermore relates to dermatological compositions without skin sensitization properties and which contain enantiomerically pure or enriched R-enantiomers of a beta2 adrenoceptor agonist.

  本发明提供了治疗皮肤结缔组织疾病，特别是治疗红斑狼疮皮肤病的有效而安全的药物。这些药物包括作为治疗活性成分的β2肾上腺素受体激动剂。此外，本发明还涉及不具有皮肤过敏特性的皮肤病治疗组合物，该组合物含有对映体纯的或β2肾上腺素受体激动剂的富集R-对映体。