α-[[(2-methoxyethyl)amino]methyl]benzenemethanol | 122150-48-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: α-[[(2-methoxyethyl)amino]methyl]benzenemethanol
• 英文别名: N-(2-Hydroxy-2-phenylethyl)-2-methoxyethylamine；alpha-[[(2-Methoxyethyl)amino]methyl]benzenemethanol；2-(2-methoxyethylamino)-1-phenylethanol
• CAS: 122150-48-5
• 化学式: C₁₁H₁₇NO₂
• mdl: MFCD11935495
• 分子量: 195.261
• InChiKey: AODQYCPQZLDHRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  α-[[(2-methoxyethyl)amino]methyl]benzenemethanol 生成 N-[2-(2-methoxyethylamino)-1-phenylethyl]acetamide
  参考文献：
  名称：

  RAGHU, SIVARAMAN

  摘要：

  DOI：
• 作为产物：
  描述：

  氧化苯乙烯 生成 α-[[(2-methoxyethyl)amino]methyl]benzenemethanol
  参考文献：
  名称：

  MUNSON, HARRY R.;(JR);TANKERSTLEY, ROBERT W. (JR)

  摘要：

  DOI：

文献信息

• Substituted dialkanolamines, sulfur analogs and condensed 1,4-oxazine
  申请人：A. H. Robins Company, Incorporated

  公开号：US04803200A1

  公开（公告）日：1989-02-07

  Substituted dialkanolamines, oxazine and sulfur analogs thereof, useful in treating shipping fever syndrome in mammals are disclosed having the formula: ##STR1## wherein: Ar is ##STR2## Z is oxygen or sulfur; R is selected from hydrogen, loweralkyl or ##STR3## R.sup.1 R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are selected from hydrogen or loweralkyl; and ##STR4## when taken together may form a lowercycloalkyl ring or R.sup.5 with --ZR.sup.2 when taken together may form a 5-membered saturated oxygen or sulfur containing heterocyclic ring; X is selected from hydrogen, halo, loweralkoxy, loweralkyl, trifluoromethyl or dimethylamino and when X is more than 1, it may be the same radical or different; y is 0, 1 or 2; n is one, or zero and when n is 1, the stereoisomers thereof and when n is zero the dotted line becomes an oxygen-carbon bond forming an oxazine ring and the pharmaceutically acceptable acid addition salts thereof.

  揭示了在治疗哺乳动物的运输热症候群中有用的取代二烷醇胺、噁唑和其硫代物，其化学式为：##STR1##其中：Ar为##STR2##Z为氧或硫；R从氢、低烷基或##STR3##中选择；R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5、R.sup.6和R.sup.7中选择自氢或低烷基；和##STR4##当一起取时，可能形成低环烷基环，或者R.sup.5与--ZR.sup.2一起取时，可能形成含氧或硫的5-成员饱和杂环环；X从氢、卤素、低烷氧基、低烷基、三氟甲基或二甲氨基中选择，当X大于1时，可能是相同的基团或不同的基团；y为0、1或2；n为1或零，当n为1时，其立体异构体，当n为零时，虚线变成氧-碳键形成噁唑环及其药用盐。
• Derivatives of 2-amino-1-phenylethanol having antiulcer activity
  申请人：A. H. Robins Company, Incorporated

  公开号：US05171753A1

  公开（公告）日：1992-12-15

  Derivatives of 2-amino-1-phenylethanol were prepared from substituted amines and benzoin, stilbene oxide or styrene oxide to give compounds of Formula: ##STR1## where R is H or (un)substituted phenyl and C is a linking group or terminal group. The compounds of this invention can inhibit ulceration in in-vivo studies in rats.

  2-氨基-1-苯基乙醇的衍生物通过取代胺和苯偶姻、芪氧化物或苯乙烯氧化物制备，得到如下通式的化合物：##STR1## 其中R为H或(未)取代的苯基，C为连接基团或端基团。本发明的这些化合物能够在体内研究中抑制大鼠的溃疡形成。
• Processes for the preparation of tetramisole
  申请人：American Cyanamid Company

  公开号：US04245103A1

  公开（公告）日：1981-01-13

  Processes for reacting arylvinyl oxides and alkoxyethylamines to provide novel N-substituted alkoxyethylamines; processes for reacting the novel N-substituted amines with nitriles to provide novel amidoamines; processes for preparing novel diamines from the amidoamines, together with the novel nitrogen-containing products so produced, such products being useful for the preparation of various imidazothiazoles including tetramisole.

  将芳基乙烯氧化物和烷氧乙胺反应以提供新型N-取代烷氧乙胺的过程；将新型N-取代胺与腈反应以提供新型酰胺胺的过程；从酰胺胺制备新型二胺的过程，以及由此产生的新型含氮产物，这些产品可用于制备各种咪唑硫唑类化合物，包括四咪唑。
• Amido methoxyethylamines
  申请人：American Cyanamid Company

  公开号：US04408072A1

  公开（公告）日：1983-10-04

  Processes for reacting arylvinyl oxides and alkoxyethylamines to provide novel N-substituted alkoxyethylamines; processes for reacting the novel N-substituted amines with nitriles to provide novel amidoamines; processes for preparing novel diamines from the amidoamines, together with the novel nitrogen-containing products so produced, such products being useful for the preparation of various imidazothiazoles including tetramisole.

  将芳基乙烯氧化物和烷氧乙基胺反应以提供新的N-取代烷氧乙基胺的方法；将新的N-取代胺与腈反应以提供新的酰胺胺的方法；从酰胺胺制备新的二胺的方法，以及由此产生的新的含氮产物，这些产物用于制备各种咪唑噻唑，包括四唑噻唑的方法。
• Novel methoxyethylamine
  申请人：American Cyanamid Company

  公开号：US04314079A1

  公开（公告）日：1982-02-02

  Processes for reacting arylvinyl oxides and alkoxyethylamines to provide novel N-substituted alkoxyethylamines; processes for reacting the novel N-substituted amines with nitriles to provide novel amidoamines; processes for preparing novel diamines from the amidoamines, together with the novel nitrogen-containing products so produced, such products being useful for the preparation of various imidazothiazoles including tetramisole.

  将芳基乙烯氧化物和烷氧基乙胺反应以提供新的N-取代烷氧基乙胺的方法；将新的N-取代胺与腈反应以提供新的酰胺胺的方法；从酰胺胺制备新的二胺的方法，以及由此产生的新的含氮产物，这些产品对于制备各种咪唑噻唑包括四唑酮非常有用的方法。