N',3,4-trihydroxybenzenecarboximidamide;hydrochloride | 95933-73-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N',3,4-trihydroxybenzenecarboximidamide;hydrochloride
• CAS: 95933-73-6
• 化学式: C7H9ClN2O3
• 分子量: 204.61
• InChiKey: AWUHRASXGNMZBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.61
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.1
• 氢给体数：
  5
• 氢受体数：
  4

文献信息

• Methods for treating or preventing neuroinflammation or autoimmune diseases
  申请人：Elford Howard L.

  公开号：US20090047250A1

  公开（公告）日：2009-02-19

  Disclosed herein are ribonucleotide reductase inhibitors, compositions comprising ribonucleotide reductase inhibitors, and methods for treating and/or preventing autoimmune diseases and neuroinflammatory diseases with the ribonucleotide reductase inhibitors.

  本文披露了核糖核酸还原酶抑制剂、包含核糖核酸还原酶抑制剂的组合物以及使用核糖核酸还原酶抑制剂治疗和/或预防自身免疫性疾病和神经炎症性疾病的方法。
• Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases
  申请人：ELFORD, Howard L.

  公开号：EP2030615A2

  公开（公告）日：2009-03-04

  Ribonucleotide reductase inhibitors, compositions comprising ribonucleotide reductase inhibitors, and methods for treating and/or preventing autoimmune diseases and neuroinflammatory diseases with the ribonucleotide reductase inhibitors.

  核糖核苷酸还原酶抑制剂、包含核糖核苷酸还原酶抑制剂的组合物，以及用核糖核苷酸还原酶抑制剂治疗和/或预防自身免疫性疾病和神经炎性疾病的方法。
• Procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis
  申请人：——

  公开号：US20010008905A1

  公开（公告）日：2001-07-19

  A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular pool of deoxyribonucleoside phosphate in an amount effective to inhibit replication of said virus. Hydroxyurea is one such suitable compound. Also disclosed is a method for producing incomplete reverse- transcriptase dependent viral DNA, by administering a deoxyribonucleoside phosphate-depleting drug to cells infected with such a virus.

  一种抑制植物或动物细胞中依赖逆转录酶病毒复制的方法，包括给所述细胞施用一种化合物，该化合物能消耗细胞内的脱氧核苷磷酸池，其有效量能抑制所述病毒的复制。羟基脲就是这样一种合适的化合物。还公开了一种产生不完全逆转录酶依赖性病毒 DNA 的方法，其方法是给感染了这种病毒的细胞施用一种磷酸脱氧核苷类药物。
• Method of inducing autovaccination against HIV infection using structured treatment interruptions
  申请人：——

  公开号：US20030095988A1

  公开（公告）日：2003-05-22

  Structured Treatment Interruptions of drug therapy for Human Immunodeficiency Virus infection can be used to enhance HIV-specific immune responses, thereby allowing the individual to control viral replication after interrupting the drug treatment. Immunoregulatory adjuvants can further increase these immune responses. A diagnostic method for the immune status of the patient that controls HIV includes measurements of viral load and production of both IFN-gamma and IL-10.

  中断人类免疫缺陷病毒感染的药物治疗可用于增强艾滋病毒特异性免疫反应，从而使患者在中断药物治疗后仍能控制病毒复制。 免疫调节佐剂可进一步增强这些免疫反应。 控制艾滋病毒患者免疫状态的诊断方法包括测量病毒载量以及 IFN-gamma 和 IL-10 的产生。
• POLYHYDROXYBENZOIC ACID DERIVATIVES
  申请人：VAN'T RIET, Bartholomeus

  公开号：EP0144396B1

  公开（公告）日：1991-01-02