(5-Chlorothiophen-2-yl)-naphthalen-1-ylmethanone | 147022-31-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (5-Chlorothiophen-2-yl)-naphthalen-1-ylmethanone
• CAS: 147022-31-9
• 化学式: C₁₅H₉ClOS
• mdl: MFCD07775986
• 分子量: 272.755
• InChiKey: FVYXXLIRRQSEQL-UHFFFAOYSA-N

物化性质

• 沸点：
  441.4±30.0 °C(predicted)
• 密度：
  1.342±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (5-Chlorothiophen-2-yl)-naphthalen-1-ylmethanone 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 以97%的产率得到(5-Chloro-thiophen-2-yl)-naphthalen-1-yl-methanol
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers

  摘要：

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.

  DOI：

  10.1016/0223-5234(92)90089-j
• 作为产物：
  描述：

  2-氯噻吩 、 1-萘甲酰氯 在 三氯化铝 作用下， 以92%的产率得到(5-Chlorothiophen-2-yl)-naphthalen-1-ylmethanone
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers

  摘要：

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.

  DOI：

  10.1016/0223-5234(92)90089-j

文献信息

• Erker; Trinkl, Scientia Pharmaceutica, 1998, vol. 66, # 3, p. 137 - 146
  作者：Erker、Trinkl

  DOI：——

  日期：——
• Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers
  作者：M Artico、G Stefancich、R Silvestri、S Massa、G Apuzzo、M Artico、G Simonetti

  DOI：10.1016/0223-5234(92)90089-j

  日期：1992.10

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.