4-Oxo-3-phenyl-2-piperidino-3,4-dihydro-chinazolin | 741-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-Oxo-3-phenyl-2-piperidino-3,4-dihydro-chinazolin
• 英文别名: 2-(piperidin-1-yl)-3-phenylquinazolin-4(3H)-one；3-phenyl-2-(piperidin-1-yl)quinazolin-4(3H)-one；3-phenyl-2-piperidin-1-yl-3H-quinazolin-4-one；3-Phenyl-2-piperidin-1-ylquinazolin-4-one
• CAS: 741-75-3
• 化学式: C₁₉H₁₉N₃O
• 分子量: 305.379
• InChiKey: VOEDQUYBWGERTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  35.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-叠氮苯甲酸 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 36.0h， 生成 4-Oxo-3-phenyl-2-piperidino-3,4-dihydro-chinazolin
  参考文献：
  名称：

  2-Mino-3H-Quinazolin-4-Ones 与串联 Aza-Wittig 反应的简便合成

  摘要：

  摘要 2-氨基-3H-喹唑啉-4-酮8 由亚氨基正膦5 与芳香异氰酸酯和亲核试剂HY 在温和条件下进行串联氮杂-Wittig 反应制备。

  DOI：

  10.1080/00397910008087195

文献信息

• Tandem Palladium-Catalyzed Addition/Cyclocarbonylation: An Efficient Synthesis of 2-Heteroquinazolin-4(<i>3H</i>)-ones
  作者：Fanlong Zeng、Howard Alper

  DOI：10.1021/ol902924x

  日期：2010.3.19

  A highly practical and efficient method for the synthesis of 2-heteroquinazolin-4(3H)-ones has been developed by a palladium-catalyzed tandem reaction. Under mild reaction conditions (80 degrees C, 100 psi), a wide variety of 2-heteroquinazolin-4(3H)-ones were obtained in good to excellent yields.
• Molybdenum-mediated synthesis of quinazolin-4(3H)-ones via cyclocarbonylation using microwave irradiation
  作者：Bryan Roberts、David Liptrot、Tim Luker、Michael J. Stocks、Catherine Barber、Nicola Webb、Robert Dods、Barrie Martin

  DOI：10.1016/j.tetlet.2011.05.052

  日期：2011.7

  A new, efficient and practical synthesis of quinazolin-4(3H)-ones is reported via molybdenum-mediated cyclocarbonylation using microwave irradiation. These methods allow access to a wide range of quinazolin-4(314)-ones in reasonable yields without the need for gaseous carbon monoxide and palladium catalysts. A range of reactions illustrating the wide scope of this chemistry was carried out and all proceeded in reasonable yields. (C) 2011 Elsevier Ltd. All rights reserved.