phenol; compound with urea | 5168-44-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: phenol; compound with urea
• 英文别名: Phenol; Verbindung mit Harnstoff；Phenol;urea
• CAS: 5168-44-5；8068-70-0；92108-93-5
• 化学式: CH₄N₂O*2C₆H₆O
• 分子量: 248.282
• InChiKey: GUGLPELUECBSDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.42
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  碳酸二苯酯 在 乙醇 、 氨 、 水 作用下， 生成 phenol; compound with urea
  参考文献：
  名称：

  Eckenroth, Archiv der Pharmazie, vol. 224, p. 623

  摘要：

  DOI：

文献信息

• Drug evolution: drug design at hot spots
  申请人：Konishi Yasuo

  公开号：US20060110743A1

  公开（公告）日：2006-05-25

  A new method of designing and generating compounds having an increased probability of being drugs, drug candidates, or biologically active compounds, in particular having a therapeutic utility, is disclosed. The method consists of identifying a group of bioactive compounds, preferably of diverse therapeutic uses or biological activities and built on a common building block. In this group of compounds, side chains modifying the building block are identified and used to generate a second set of compounds according to the proposed methods of hybridization”, “single substitution” or “incorporation of frequently used side chains”. If the compounds in the second set built on the same building block contain an unusually large number of drugs, preferably with diverse therapeutic uses or biological activities, they constitute a “hot spot”. A focused combinatorial library of the “hot spot” is then generated, preferably by methods of combinatorial chemistry, and compounds of this library are screened for a variety of therapeutic uses or biological activities. The method generates drugs, drug candidates, or biologically active compounds with a high probability, without requiring any prior knowledge of biological targets.

  本文揭示了一种设计和生成化合物的新方法，这些化合物具有成为药物、药物候选物或生物活性化合物的概率增加，特别是具有治疗效用。该方法包括识别一组生物活性化合物，最好是具有不同治疗用途或生物活性，并建立在共同的基础上。在这组化合物中，识别修改基础结构的侧链，并使用“杂交”、“单一替换”或“纳入常用侧链”的建议方法生成第二组化合物。如果第二组化合物建立在相同的基础结构上，包含异常数量的药物，最好是具有不同治疗用途或生物活性，它们构成一个“热点”。然后通过组合化学的方法生成一个专注的组合式库，其中包括“热点”的化合物，并对该库中的化合物进行各种治疗用途或生物活性的筛选。该方法生成的药物、药物候选物或生物活性化合物具有高概率，无需任何先前的生物靶标知识。
• Benzimidazole Derivatives And Their Pharmaceutical Compositions And Uses
  申请人：Huang Zhenhua

  公开号：US20130023568A1

  公开（公告）日：2013-01-24

  The present invention relates to benzimidazole derivatives and their pharmaceutical compositions and uses, specifically to benzimidazole derivatives of Formula (I), or their stereoisomer, pharmaceutically acceptable salt or solvates thereof, in which R 1 , R 2 , R 3 , R 4 , R 5 and n have the definitions in the description; the present invention further relates to a pharmaceutical composition containing the compounds, methods for preparing the compounds, and use of the compounds for manufacturing of a medicament for prophylaxis and/or treatment of peptic ulcer, ulcer hemorrhage and diseases associated with gastric acid.

  本发明涉及苯并咪唑衍生物及其制药组合物和用途，具体涉及公式（I）的苯并咪唑衍生物或其立体异构体、药学上可接受的盐或溶剂，其中R1、R2、R3、R4、R5和n在说明书中有定义；本发明还涉及含有该化合物的制药组合物、制备该化合物的方法以及利用该化合物制造用于预防和/或治疗消化性溃疡、溃疡出血和与胃酸有关的疾病的药物的用途。
• BENZIMIDAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES
  申请人：Xuanzhu Pharma Co., Ltd.

  公开号：US20160176892A1

  公开（公告）日：2016-06-23

  The present invention relates to benzimidazole derivatives and their pharmaceutical compositions and uses, specifically to benzimidazole derivatives of Formula (I), or their stereoisomer, pharmaceutically acceptable salt or solvates thereof, in which R 1 , R 2 , R 3 , R 4 , R 5 and n have the definitions in the description; the present invention further relates to a pharmaceutical composition containing the compounds, methods for preparing the compounds, and use of the compounds for manufacturing of a medicament for prophylaxis and/or treatment of peptic ulcer, ulcer hemorrhage and diseases associated with gastric acid.

  本发明涉及苯并咪唑衍生物及其制药组合物和用途，具体涉及公式（I）的苯并咪唑衍生物或其立体异构体，其药学上可接受的盐或溶剂，其中R1、R2、R3、R4、R5和n在说明中有定义；本发明还涉及含有该化合物的制药组合物，制备该化合物的方法，以及将该化合物用于制造预防和/或治疗消化性溃疡、溃疡出血和与胃酸有关的疾病的药物的用途。
• Amino resin and a method for its production
  申请人：DYNOBEL A/S

  公开号：EP0277106A1

  公开（公告）日：1988-08-03

  The invention relates to a resin for the production of cellulose based products, such as particle boards. The resin is a condensation product of formaldehyde, urea and phenol and optionally melamine with a molar ratio of 1.4-­0.8 moles of urea, 0.006 - 0.04 moles of phenol and 0-­0.04 moles of melamine per mole formaldehyde. The invention also relates to a method of producing such a resin. Accor­ding to the method a separately prepared cross-linking agent containing a co-condensate of phenol, formaldehyde and urea or containing a co-condensate of phenol and formaldehyde together with urea, is added to a pre-conden­sate of formaldehyde, urea and optionally melamine, where­after the mixture is condensed. As an alternative the cross-linking agent can be added to a finished condensate of formaldehyde, urea and optionally melamine. The invention also relates to a method of manufactur­ing glued cellulose based products.

  本发明涉及一种用于生产纤维素基产品（如刨花板）的树脂。该树脂是甲醛、尿素、苯酚和三聚氰胺的缩合产物，每摩尔甲醛中尿素的摩尔比为 1.4-0.8 摩尔，苯酚的摩尔比为 0.006-0.04 摩尔，三聚氰胺的摩尔比为 0-0.04 摩尔。本发明还涉及一种生产这种树脂的方法。根据该方法，将单独制备的含有苯酚、甲醛和尿素的共缩合物或含有苯酚、甲醛和尿素的共缩合物的交联剂加入到甲醛、尿素和三聚氰胺的预缩合物中，然后对混合物进行缩合。另一种方法是将交联剂添加到甲醛、尿素和三聚氰胺的成品缩合物中。 本发明还涉及一种制造胶基纤维素产品的方法。
• A method for the production of amino resin
  申请人：DYNOBEL A/S

  公开号：EP0277926A3

  公开（公告）日：1990-08-16

  The invention relates to a method for the production of a resin which is used for manufacturing of an adhesive for cellulose based products, According to the method 30-­70 % by weight of a urea phenol resin with a molar ratio of 1.4 - 0.6 moles of urea, 0.006 - 0.3 moles of phenol and 0 - 0.04 moles of melamine per mole formaldehyde, are mixed with 70 - 30 % by weight of a melamine resin with a molar ratio formaldehyde : melamine of 1.7 - 2.4. The urea-phenol resin has been prepared by adding a cross-linking agent containing a co-condensate of phenol, formaldehyde and urea to a pre-condensate of formaldehyde, urea and optionally melamine and condensing under acid conditions.According to a further embodiment the cross-linking agent is added to a evaporated condensate of formaldehyde, urea and optionally melamine.

  本发明涉及一种用于生产纤维素基产品粘合剂的树脂的生产方法，根据该方法，以重量计，30-70%的脲酚树脂（摩尔比为1.将每摩尔甲醛含 0.006 - 0.3 摩尔脲、0.006 - 0.3 摩尔酚和 0 - 0.04 摩尔三聚氰胺的脲酚树脂与 70 - 30% 重量的三聚氰胺树脂混合，三聚氰胺树脂中甲醛与三聚氰胺的摩尔比为 1.7 - 2.4。脲酚树脂的制备方法是将含有苯酚、甲醛和尿素共缩合物的交联剂加入到甲醛、尿素和三聚氰胺的预缩合物中，并在酸性条件下缩合。