calycin | 10091-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: calycin
• 英文别名: (3E)-3-(3-hydroxy-5-oxo-4-phenylfuran-2-ylidene)-1-benzofuran-2-one
• CAS: 10091-92-6；15222-44-3
• 化学式: C₁₈H₁₀O₅
• 分子量: 306.274
• InChiKey: CGRCGRBHNKRILW-JQIJEIRASA-N

物化性质

• 熔点：
  240 °C
• 沸点：
  502.4±50.0 °C(Predicted)
• 密度：
  1.564±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 4-methoxy-2-(2-methoxyphenyl)-3-trimethylsilyloxybut-2-enoate 在 吡啶 、 potassium phosphate 、 四(三苯基膦)钯 、 三氟甲磺酸三甲基硅酯 、 三溴化硼 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 41.0h， 生成 calycin
  参考文献：
  名称：

  通过顺序“[3+2] 环化/铃木/内酯化”反应合成 Leprapinic Acid、Calycine 和类似物

  摘要：

  花萼和类似物是在 γ-亚烷基-α-羟基丁烯内酯的 Suzuki 交叉偶联反应的基础上制备的 - 通过 1,3-二羰基二价阴离子或 1,3-双（甲硅烷基烯醇醚）与草酰衍生物的环化很容易获得 -以及随后的三溴化硼介导的内酯化。Leprapinic 酸是通过化学选择性三溴化硼介导的全甲基化 Leprapinic 酸的脱保护制备的。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

  DOI：

  10.1002/ejoc.200500142

文献信息

• Peptide-based conditioners and colorants for hair, skin, and nails
  申请人：Huang Xueying

  公开号：US20050050656A1

  公开（公告）日：2005-03-10

  Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants based are described. The peptide-based hair conditioners and hair colorants consist of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants consist of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants consist of a nail-binding peptide coupled to a coloring agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based conditioners and colorants are also described.

  已经确定了与头发、皮肤和指甲高亲和力结合的肽。描述了基于肽的头发护理剂、染发剂、皮肤护理剂、皮肤染色剂和指甲染色剂。基于肽的头发护理剂和染发剂包括一个与头发结合的肽，分别耦合到头发护理剂或染色剂上。基于肽的皮肤护理剂和皮肤染色剂包括一个与皮肤结合的肽，分别耦合到皮肤护理剂或染色剂上。基于肽的指甲染色剂包括一个与指甲结合的肽，耦合到染色剂上。在所有这些组合中，肽可以直接耦合到活性剂上，或者通过间隔物进行耦合。还描述了含有这些基于肽的护理剂和染色剂的个人护理组合物。
• Methods of treating IgE-associated disorders and compositions for use therein
  申请人：Dynavax Technologies Corporation

  公开号：EP1671646A2

  公开（公告）日：2006-06-21

  The present invention provides methods of treating IgE-associated disorders and compositions for use therein. The methods are particularly useful in treatment of allergies and allergy-related disorders. The methods generally comprise administering an IgE inhibitor (such as anti-IgE antibody) and an antigen and/or immunostimulatory polynucleotide sequence (ISS). These combination methods offer significant advantages, such as allowing more aggressive therapy while reducing unwanted side effects, such as anaphylaxis.

  本发明提供了治疗 IgE 相关疾病的方法及其使用的组合物。这些方法特别适用于治疗过敏和过敏相关疾病。这些方法一般包括施用 IgE 抑制剂（如抗 IgE 抗体）和抗原和/或免疫刺激多核苷酸序列（ISS）。这些组合方法具有显著的优势，例如可以进行更积极的治疗，同时减少不必要的副作用，如过敏性休克。
• Use of a recombinant modified vaccinia virus Ankara (MVA) for the treatment of type I hypersensitivity in a living animal including humans
  申请人：Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe

  公开号：EP1835031A1

  公开（公告）日：2007-09-19

  The present invention relates to the use of a recombinant modified vaccinia virus Ankara (MVA) comprising a heterologous nucleic acid for the production of a medicament for the prevention and/or treatment of type I hypersensitivity in a living animal including humans. The invention further relates to a recombinant modified vaccinia virus Ankara (MVA) comprising a heterologous nucleic acid, wherein the heterologous nucleic acid is incorporated into a non-essential region of the genome of the MVA, the heterologous nucleic acid is under the control of, e.g. a vaccinia virus-specific promoter and, the heterologous nucleic acid is selected from the group of nucleic acids encoding an allergen selected from the group of weed pollens, grass pollens, tree pollens, mites, animals, fungi, insects, rubber, worms, human autoallergens, and foods.

  本发明涉及一种包含异源核酸的重组修饰的安卡拉疫苗病毒（MVA）用于生产预防和/或治疗活体动物（包括人类）I型超敏反应的药物。本发明还涉及一种重组改良的安卡拉疫苗病毒（MVA），它包含异源核酸，其中异源核酸被整合到 MVA 基因组的非必要区，异源核酸受控制，例如受疫苗病毒特异性的控制。g. 疫苗病毒特异性启动子的控制下，并且，异源核酸选自编码选自杂草花粉、草花粉、树花粉、螨虫、动物、真菌、昆虫、橡胶、蠕虫、人类自身过敏原和食物的过敏原的核酸组。
• Peptide-based body surface reagents for personal care
  申请人：E. I. Du Pont de Nemours and Company

  公开号：EP2016934A1

  公开（公告）日：2009-01-21

  Peptides have been identified that bind with high affinity to body surfaces, such as hair, skin, nails, teeth, gums, corneal tissue, and oral cavity surfaces. Peptide-based body surface reagents formed by coupling a body surface binding peptide to a benefit agent are described. The peptide-based body surface reagents include peptide-based hair conditioners, hair colorant, skin conditioners, skin colorants, nail colorants and oral care reagents. The peptide-based hair conditioners and hair colorants are comprised of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants are comprised of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants are comprised of a nail-binding peptide coupled to a coloring agent. The peptide-based oral care reagents are comprised of an oral cavity surface-binding peptide coupled to an oral care benefit agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based conditioners and colorants are also described.

  已发现一些肽能以高亲和力与体表结合，如头发、皮肤、指甲、牙齿、牙龈、角膜组织和口腔表面。本文介绍了通过将体表结合肽与益处剂偶联而形成的肽基体表试剂。肽基体表试剂包括肽基护发素、染发剂、皮肤护理剂、皮肤着色剂、指甲着色剂和口腔护理试剂。多肽护发素和染发剂分别由与头发结合的多肽和护发剂或染发剂组成。多肽类皮肤护理剂和皮肤着色剂分别由与皮肤护理剂或着色剂偶联的皮肤结合肽组成。多肽指甲着色剂由与着色剂偶联的指甲结合肽组成。多肽口腔护理试剂由口腔表面结合肽和口腔护理剂组成。在所有这些组合物中，肽可以直接与活性剂结合，也可以通过间隔物结合。此外，还介绍了含有这些肽基护理剂和着色剂的个人护理组合物。
• Immunomodulatory formulations and methods for use thereof
  申请人：Dynavax Technologies Corporation

  公开号：EP2067487A2

  公开（公告）日：2009-06-10

  The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a nonbiodegradable microcarrier or nanocarrier.

  本发明提供了用于个体免疫调节的新组合物和方法。免疫调节是通过施用免疫调节多核苷酸/微载体（IMP/MC）复合物来实现的。IMP/MC 复合物可以是共价结合或非共价结合，其特征是包含至少一个免疫刺激序列的多核苷酸与不可生物降解的微载体或纳米载体结合。